The POINTER Imaging baseline cohort: Associations between multimodal neuroimaging biomarkers, cardiovascular health, and cognition

Harrison TM, Ward T, Taggett J, Maillard P, Lockhart SN, Jung Y, Lovato LC, Koeppe R, Jagust WJ, Harvey D, Masdeu JC, Oh H, Gitelman DR, Aggarwal NT, Espeland MA, Cleveland ML, Whitmer R, Farias ST, Salloway S, Pavlik V, Yu M, Tangney C, Snyder H, Carrillo M, Baker LD, Vemuri P, DeCarli C, Landau SM; U.S. POINTER Study Group

Alzheimers Dement. 2024 Dec 6. doi: 10.1002/alz.14399. Epub ahead of print. PMID: 39641363.

The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)

Mormino EC, Biber SA, Rahman-Filipiak A, Arfanakis K, Clark L, Dage JL, Detre JA, Dickerson BC, Donohue MC, Kecskemeti S, Hohman TJ, Jagust WJ, Keene DC, Kukull W, Levendovszky SR, Rosen H, Thompson PM, Villemagne VL, Wolk DA, Okonkwo OC, Rabinvovici GD, Rivera-Mindt M, Foroud T, Johnson SC

Alzheimers Dement. 2024 Nov 26. doi: 10.1002/alz.14383. Epub ahead of print. PMID: 39588767.

Positron emission tomography harmonization in the Alzheimer's Disease Neuroimaging Initiative: A scalable and rigorous approach to multisite amyloid and tau quantification

Landau SM, Harrison TM, Baker SL, Boswell MS, Lee J, Taggett J, Ward TJ, Chadwick T, Murphy A, DeCarli C, Schwarz CG, Vemuri P, Jack CR Jr, Koeppe RA, Jagust WJ

Alzheimers Dement. 2024 Nov 19. doi: 10.1002/alz.14378. Epub ahead of print. PMID: 39559932.

Cross-sectional and longitudinal relationships among blood-brain barrier disruption, Alzheimer's disease biomarkers, and cognition in cognitively normal older adults

Denkinger M, Baker S, Harrison TM, Chadwick T, Jagust WJ

Neurobiol Aging. 2024 Nov 14;146:15-23. doi: 10.1016/j.neurobiolaging.2024.11.002. Epub ahead of print. PMID: 39571410.

Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation

Shanaki Bavarsad M, Spina S, Oehler A, Allen IE, Suemoto CK, Leite REP, Seeley WS, Green A, Jagust W, Rabinovici GD, Grinberg LT

Acta Neuropathol. 2024 Oct 30;148(1):58. doi: 10.1007/s00401-024-02816-9. PMID: 39476256.

No In Vivo Evidence for Estrogen Receptor Density Changes in Human Neuroendocrine Aging or Their Relationship to Cognition and Menopausal Symptoms

Biegon A, Jagust W, Mankoff DA

J Nucl Med. 2024 Nov 1;65(11):1818-1819. doi: 10.2967/jnumed.124.268782. PMID: 39486864.

Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults

Chen X, Juarez A, Mason S, Kobayashi S, Baker SL, Harrison TM, Landau SM, Jagust WJ.

Neurobiol Aging. 2024 Oct 19;145:32-41. doi: 10.1016/j.neurobiolaging.2024.10.004. Epub ahead of print. PMID: 39490245.

Implementation and validation of face de-identification (de-facing) in ADNI4

Schwarz CG, Choe M, Rossi S, Das SR, Ittyerah R, Fletcher E, Maillard P, Singh B, Harvey DJ, Malone IB, Prosser L, Senjem ML, Matoush LC, Ward CP, Prakaashana CM, Landau SM, Koeppe RA, Lee J, DeCarli C, Weiner MW, Jack CR Jr, Jagust WJ, Yushkevich PA, Tosun D; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2024 Oct 11. doi: 10.1002/alz.14303. Epub ahead of print. PMID: 39392215.

A dopaminergic basis of behavioral control

Ballard IC, Furman DJ, Berry AS, White RL, Jagust WJ, Kayser AS, D'Esposito M.

Ballard IC, Furman DJ, Berry AS, White RL, Jagust WJ, Kayser AS, D'Esposito M. A dopaminergic basis of behavioral control. bioRxiv [Preprint]. 2024 Oct 2:2024.09.17.613524. doi: 10.1101/2024.09.17.613524. PMID: 39345422; PMCID: PMC11429830.

Alzheimer Disease Is a Specific Disorder Defined by Neuropathology Detectable During Life

Jagust WJ

Jagust WJ. Alzheimer Disease Is a Specific Disorder Defined by Neuropathology Detectable During Life. Neurology. 2024 Nov 12;103(9):e209995. doi: 10.1212/WNL.0000000000209995. Epub 2024 Oct 1. PMID: 39353146.

CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET

Nho K, Risacher SL, Apostolova LG, Bice PJ, Brosch JR, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR Jr, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Ertekin-Taner N, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI); Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN); Australian Imaging, Biomarker & Lifestyle Study (AIBL); Saykin AJ.

Nat Commun. 2024 Sep 20;15(1):8251. doi: 10.1038/s41467-024-52298-2. PMID: 39304655; PMCID: PMC11415491.

Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions

Giorgio J, Jonson C, Wang Y, Yokoyama J, Wang J, Jagust W.

Res Sq [Preprint]. 2024 Aug 9:rs.3.rs-4804430. doi: 10.21203/rs.3.rs-4804430/v1. PMID: 39149503; PMCID: PMC11326369.

The ADNI PET Core at 20

Jagust WJ, Koeppe RA, Rabinovici GD, Villemagne VL, Harrison TM, Landau SM; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2024 Aug 6. doi: 10.1002/alz.14165. Epub ahead of print. PMID: 39108002.

Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model

Leuzy A, Raket LL, Villemagne VL, Klein G, Tonietto M, Olafson E, Baker S, Saad ZS, Bullich S, Lopresti B, Bohorquez SS, Boada M, Betthauser TJ, Charil A, Collins EC, Collins JA, Cullen N, Gunn RN, Higuchi M, Hostetler E, Hutchison RM, Iaccarino L, Insel PS, Irizarry MC, Jack CR Jr, Jagust WJ, Johnson KA, Johnson SC, Karten Y, Marquié M, Mathotaarachchi S, Mintun MA, Ossenkoppele R, Pappas I, Petersen RC, Rabinovici GD, Rosa-Neto P, Schwarz CG, Smith R, Stephens AW, Whittington A, Carrillo MC, Pontecorvo MJ, Haeberlein SB, Dunn B, Kolb HC, Sivakumaran S, Rowe CC, Hansson O, Doré V.

Alzheimers Dement. 2024 Jul 23. doi: 10.1002/alz.13908. Epub ahead of print. PMID: 39041435.

Pathological and neurochemical correlates of locus coeruleus functional network activity

Parent JH, Cassady K, Jagust WJ, Berry AS.

Biol Psychol. 2024 Jul 20;192:108847. doi: 10.1016/j.biopsycho.2024.108847. Epub ahead of print. PMID: 39038634.

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup

Jack CR Jr, Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A, Hansson O, Ho C, Jagust W, McDade E, Molinuevo JL, Okonkwo OC, Pani L, Rafii MS, Scheltens P, Siemers E, Snyder HM, Sperling R, Teunissen CE, Carrillo MC.

Alzheimers Dement. 2024 Jun 27. doi: 10.1002/alz.13859. Epub ahead of print. PMID: 38934362.

Associations between regional blood-brain barrier permeability, aging, and Alzheimer's disease biomarkers in cognitively normal older adults

Denkinger M, Baker S, Inglis B, Kobayashi S, Juarez A, Mason S, Jagust W.

PLoS One. 2024 Jun 5;19(6):e0299764. doi: 10.1371/journal.pone.0299764. PMID: 38837947; PMCID: PMC11152304.

Cognitive Trajectories and Alzheimer Disease Biomarkers: From Successful Cognitive Aging to Clinical Impairment

Harrison TM, Chadwick T, Pezzoli S, Lee J, Landau SM, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Ann Neurol. 2024 May 15. doi: 10.1002/ana.26964. Epub ahead of print. PMID: 38747315.

Alzheimer's disease prevention: Apolipoprotein e4 moderates the effect of physical activity on brain beta-amyloid deposition in healthy older adults

Pedrero-Chamizo R, Zhuang K, Juarez A, Janabi M, Jagust WJ, Landau SM.

J Sci Med Sport. 2024 Apr 3:S1440-2440(24)00109-9. doi: 10.1016/j.jsams.2024.03.012. Epub ahead of print. PMID: 38664148.

Behaviorally meaningful functional networks mediate the effect of Alzheimer's pathology on cognition

Ziontz J, Harrison TM, Chen X, Giorgio J, Adams JN, Wang Z, Jagust W; Alzheimer’s Disease Neuroimaging Initiative.

Cereb Cortex. 2024 Apr 1;34(4):bhae134. doi: 10.1093/cercor/bhae134. PMID: 38602736; PMCID: PMC11008686.

Quantitative Brain Amyloid PET

Jagust WJ, Mattay VS, Krainak DM, Wang SJ, Weidner LD, Hofling AA, Koo H, Hsieh P, Kuo PH, Farrar G, Marzella L.

J Nucl Med. 2024 Mar 21:jnumed.123.265766. doi: 10.2967/jnumed.123.265766. Epub ahead of print. PMID: 38514082.

Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease

Maboudian SA, Willbrand EH, Jagust WJ, Weiner KS.

J Neurosci. 2024 Feb 21:e1714232024. doi: 10.1523/JNEUROSCI.1714-23.2024. Epub ahead of print. PMID: 38383497.

Tau accumulation and atrophy predict amyloid independent cognitive decline in aging

Fonseca CS, Baker SL, Dobyns L, Janabi M, Jagust WJ, Harrison TM.

Alzheimers Dement. 2024 Feb 9. doi: 10.1002/alz.13654. Epub ahead of print. PMID: 38334195.

Individuals with Alzheimer's disease and low tau burden: Characteristics and implications

Landau SM, Lee J, Murphy A, Ward TJ, Harrison TM, Baker SL, DeCarli C, Harvey D, Tosun D, Weiner MW, Koeppe RA, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2024 Jan 19. doi: 10.1002/alz.13609. Epub ahead of print. PMID: 38241084.

Amyloid induced hyperexcitability in default mode network drives medial temporal hyperactivity and early tau accumulation

Giorgio J, Adams JN, Maass A, Jagust WJ, Breakspear M.

Neuron. 2023 Dec 11:S0896-6273(23)00888-7. doi: 10.1016/j.neuron.2023.11.014. Epub ahead of print. PMID: 38096815.

Regional tau deposition reflects different pathways of subsequent neurodegeneration and memory decline in cognitively normal older adults

Chen X, Toueg TN, Harrison TM, Baker SL, Jagust WJ.

Ann Neurol. 2023 Oct 3. doi: 10.1002/ana.26813. Epub ahead of print. PMID: 37789559.

Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment

Mundada NS, Rojas JC, Vandevrede L, Thijssen EH, Iaccarino L, Okoye OC, Shankar R, Soleimani-Meigooni DN, Lago AL, Miller BL, Teunissen CE, Heuer H, Rosen HJ, Dage JL, Jagust WJ, Rabinovici GD, Boxer AL, La Joie R.

Alzheimers Res Ther. 2023 Sep 22;15(1):157. doi: 10.1186/s13195-023-01302-w. PMID: 37740209; PMCID: PMC10517500.

Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology

Han F, Lee J, Chen X, Ziontz J, Ward T, Landau SM, Baker SL, Harrison TM, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.557492. doi: 10.1101/2023.09.12.557492. PMID: 37745434; PMCID: PMC10515801.

The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022

Veitch DP, Weiner MW, Miller M, Aisen PS, Ashford MA, Beckett LA, Green RC, Harvey D, Jack CR Jr, Jagust W, Landau SM, Morris JC, Nho KT, Nosheny R, Okonkwo O, Perrin RJ, Petersen RC, Rivera Mindt M, Saykin A, Shaw LM, Toga AW, Tosun D; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2023 Sep 12. doi: 10.1002/alz.13449. Epub ahead of print. PMID: 37698424.

Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging

Pezzoli S, Giorgio J, Martersteck A, Dobyns L, Harrison TM, Jagust WJ.

Alzheimers Dement. 2023 Aug 24. doi: 10.1002/alz.13438. Epub ahead of print. PMID: 37614157.

Effect of Alzheimer's pathology on task-related brain network reconfiguration in aging

Cassady KE, Chen X, Adams JN, Harrison TM, Zhuang K, Maass A, Baker S, Jagust W.

J Neurosci. 2023 Aug 18:JN-RM-0023-23. doi: 10.1523/JNEUROSCI.0023-23.2023. Epub ahead of print. PMID: 37604690.

A robust harmonization approach for cognitive data from multiple aging and dementia cohorts

Giorgio J, Tanna A, Malpetti M, White SR, Wang J, Baker S, Landau S, Tanaka T, Chen C, Rowe JB, O'Brien J, Fripp J, Breakspear M, Jagust W, Kourtzi Z; Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study.

Alzheimers Dement (Amst). 2023 Jul 26;15(3):e12453. doi: 10.1002/dad2.12453. PMID: 37502020; PMCID: PMC10369372.

Poorer aging trajectories are associated with elevated serotonin synthesis capacity

Markova TZ, Ciampa CJ, Parent JH, LaPoint MR, D'Esposito M, Jagust WJ, Berry AS.

Mol Psychiatry. 2023 Jul 17. doi: 10.1038/s41380-023-02177-x. Epub ahead of print. PMID: 37460847.

The complex pathway between amyloid β and cognition: implications for therapy

Jagust WJ, Teunissen CE, DeCarli C.

Lancet Neurol. 2023 Jul 13:S1474-4422(23)00128-X. doi: 10.1016/S1474-4422(23)00128-X. Epub ahead of print. PMID: 37454670.

Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease

Maboudian SA, Willbrand EH, Jagust WJ, Weiner KS; Alzheimer’s Disease Neuroimaging Initiative.

bioRxiv [Preprint]. 2023 Jul 1:2023.06.29.546558. doi: 10.1101/2023.06.29.546558. PMID: 37425904; PMCID: PMC10327001.

Striatal dopamine synthesis and cognitive flexibility differ between hormonal contraceptive users and nonusers

Taylor CM, Furman DJ, Berry AS, White Iii RL, Jagust WJ, D'Esposito M, Jacobs EG.

Cereb Cortex. 2023 May 9:bhad134. doi: 10.1093/cercor/bhad134. Epub ahead of print. PMID: 37160338.

NREM sleep as a novel protective cognitive reserve factor in the face of Alzheimer's disease pathology

Zavecz Z, Shah VD, Murillo OG, Vallat R, Mander BA, Winer JR, Jagust WJ, Walker MP.

BMC Med. 2023 May 3;21(1):156. doi: 10.1186/s12916-023-02811-z. PMID: 37138290; PMCID: PMC10155344.

Novel CYP1B1-RMDN2 Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET

Nho K, Risacher SL, Apostolova L, Bice PJ, Brosch J, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Neuroimaging Initiative – Department of Defense; Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study); Australian Imaging, Biomarker & Lifestyle Study (AIBL); Saykin AJ.

medRxiv [Preprint]. 2023 Mar 22:2023.02.27.23286048. doi: 10.1101/2023.02.27.23286048. PMID: 36993271; PMCID: PMC10055458.

An empirical measure of resilience explains individual differences in the effect of tau pathology on memory change in aging

Dobyns L, Zhuang K, Baker SL, Mungas D, Jagust WJ, Harrison TM.

Nat Aging. 2023 Feb;3(2):229-237. doi: 10.1038/s43587-022-00353-2. Epub 2023 Feb 6. PMID: 37118122; PMCID: PMC10148952.

Optimizing quantification of MK6240 tau PET in unimpaired older adults

Harrison TM, Ward TJ, Murphy A, Baker SL, Dominguez PA, Koeppe R, Vemuri P, Lockhart SN, Jung Y, Harvey DJ, Lovato L, Toga AW, Masdeu J, Oh H, Gitelman DR, Aggarwal N, Snyder HM, Baker LD, DeCarli C, Jagust WJ, Landau SM; U.S. POINTER Study Group.

Neuroimage. 2022 Nov 28:119761. doi: 10.1016/j.neuroimage.2022.119761. Epub ahead of print. PMID: 36455762.

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

Ossenkoppele R, Pichet Binette A, Groot C, Smith R, Strandberg O, Palmqvist S, Stomrud E, Tideman P, Ohlsson T, Jögi J, Johnson K, Sperling R, Dore V, Masters CL, Rowe C, Visser D, van Berckel BNM, van der Flier WM, Baker S, Jagust WJ, Wiste HJ, Petersen RC, Jack CR Jr, Hansson O.

Nat Med. 2022 Nov 10. doi: 10.1038/s41591-022-02049-x. Epub ahead of print. PMID: 36357681.

Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4

Albala B, Beckett LA, Green RC, Harvey D, Jack CR Jr, Jagust W, Landau SM, Morris JC, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2022 Oct 9. doi: 10.1002/alz.12797. Epub ahead of print. PMID: 36209495.

Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging

Parent JH, Ciampa CJ, Harrison TM, Adams JN, Zhuang K, Betts MJ, Maass A, Winer JR, Jagust WJ, Berry AS.

Neuroimage. 2022 Sep 30:119658. doi: 10.1016/j.neuroimage.2022.119658. Epub ahead of print. PMID: 36191755.

Metacognition, cortical thickness, and tauopathy in aging

Zhuang K, Chen X, Cassady KE, Baker SL, Jagust WJ.

Neurobiol Aging. 2022 Jun 25;118:44-54. doi: 10.1016/j.neurobiolaging.2022.06.007. Epub ahead of print. PMID: 35868093.

Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease

Ranasinghe K, Verma P, Cai C, Xie X, Kudo K, Gao X, Lerner H, Mizuiri D, Strom A, Iaccarino L, La Joie R, Miller BL, Gorno-Tempini ML, Rankin KP, Jagust WJ, Vossel K, Rabinovici G, Raj A, Nagarajan S.

Elife. 2022 May 26;11:e77850. doi: 10.7554/eLife.77850. Epub ahead of print. PMID: 35616532.

Autosomal dominant and sporadic late onset Alzheimer disease share a common in vivo pathophysiology

Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, Fagan AM, Farlow M, Fox NC, Ghetti B, Goate AM, Gordon BA, Graff-Radford N, Day GS, Hassenstab J, Ikeuchi T, Jack CR, Jagust WJ, Jucker M, Levin J, Massoumzadeh P, Masters CL, Martins R, McDade E, Mori H, Noble JM, Petersen RC, Ringman JM, Salloway S, Saykin AJ, Schofield PR, Shaw LM, Toga AW, Trojanowski JQ, Vöglein J, Weninger S, Bateman RJ, Buckles VD; Dominantly Inherited Alzheimer Network and the Alzheimer’s Disease Neuroimaging Initiative.

Brain. 2022 May 17:awac181. doi: 10.1093/brain/awac181. Epub ahead of print. PMID: 35580594.

A Double-Edged Sword: The Role of Prior Knowledge in Memory Aging

Chen X, Varghese L, Jagust WJ.

Front Aging Neurosci. 2022 May 10;14:874767. doi: 10.3389/fnagi.2022.874767. PMID: 35619942; PMCID: PMC9127270.

Longitudinal Trajectories of Memory Performance in Patients with Early-Stage Breast Cancer

Apple AC, Lindbergh CA, Landau SM, DeLuca A, Eberling JL, Jagust WJ, Kramer JH, Rugo HS, Heflin LH.

J Oncol. 2022 Apr 16;2022:5899728. doi: 10.1155/2022/5899728. PMID: 35469310; PMCID: PMC9034940.

Quantification of amyloid beta and tau PET without a structural MRI

Landau SM, Ward TJ, Murphy A, Iaccarino L, Harrison TM, La Joie R, Baker S, Koeppe RA, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2022 Apr 16. doi: 10.1002/alz.12668. Epub ahead of print. PMID: 35429219

A robust and interpretable machine learning approach using multimodal biological data to predict future pathological tau accumulation

Giorgio J, Jagust WJ, Baker S, Landau SM, Tino P, Kourtzi Z; Alzheimer’s Disease Neuroimaging Initiative.

Nat Commun. 2022 Apr 7;13(1):1887. doi: 10.1038/s41467-022-28795-7. PMID: 35393421

Rates of β-amyloid deposition indicate widespread simultaneous accumulation throughout the brain

LaPoint MR, Baker SL, Landau SM, Harrison TM, Jagust WJ.

Neurobiol Aging. 2022 Mar 14;115:1-11. doi: 10.1016/j.neurobiolaging.2022.03.005. Epub ahead of print. PMID: 35447369.

Associations among locus coeruleus catecholamines, tau pathology, and memory in aging.

Ciampa CJ, Parent JH, Harrison TM, Fain RM, Betts MJ, Maass A, Winer JR, Baker SL, Janabi M, Furman DJ, D'Esposito M, Jagust WJ, Berry AS.

Neuropsychopharmacology. 2022 Jan 15. doi: 10.1038/s41386-022-01269-6. PMID: 35034099

The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI-3 updates and global perspectives.

Weber CJ, Carrillo MC, Jagust W, Jack CR Jr, Shaw LM, Trojanowski JQ, Saykin AJ, Beckett LA, Sur C, Rao NP, Mendez PC, Black SE, Li K, Iwatsubo T, Chang CC, Sosa AL, Rowe CC, Perrin RJ, Morris JC, Healan AMB, Hall SE, Weiner MW.

Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12226. doi: 10.1002/trc2.12226. eCollection 2021. PMID: 35005206

Distinct factors drive the spatiotemporal progression of tau pathology in older adults.

Adams JN, Harrison TM, Maass A, Baker SL, Jagust WJ.

J Neurosci. 2021 Dec 15:JN-RM-1601-21. doi: 10.1523/JNEUROSCI.1601-21.2021. PMID: 34965972

Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging.

Ciampa CJ, Parent JH, Lapoint MR, Swinnerton KN, Taylor MM, Tennant VR, Whitman AJ, Jagust WJ, Berry AS.

Cereb Cortex. 2021 Oct 27:bhab379. doi: 10.1093/cercor/bhab379. PMID: 34718454

Sequential Pathway Inference for Multimodal Neuroimaging Analysis

Li L, Shi C, Guo T, Jagust WJ.

Stat. 2022 Dec;11(1):e433. doi: 10.1002/sta4.433. Epub 2021 Oct 15. PMID: 35450402; PMCID: PMC9017676.

Age, vascular disease, and Alzheimer's disease pathologies in amyloid negative elderly adults.

Guo T, Landau SM, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Res Ther. 2021 Oct 15;13(1):174. doi: 10.1186/s13195-021-00913-5. PMID: 34654465

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum.

Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR Jr, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12480. PMID: 34647694

Abnormal tau in amyloid PET negative individuals.

Yoon B, Guo T, Provost K, Korman D, Ward TJ, Landau SM, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2021 Sep 30;109:125-134. doi: 10.1016/j.neurobiolaging.2021.09.019. PMID: 34715443

Fusiform gyrus phospho-tau is associated with failure of proper name retrieval in aging.

Tennant VR, Harrison TM, Adams JN, La Joie R, Winer JR, Jagust WJ.

Ann Neurol. 2021 Sep 29. doi: 10.1002/ana.26237. PMID: 34590340

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.

Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, Harvey D, Jack CR Jr, Jagust W, Landau SM, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2021 Sep 28. doi: 10.1002/alz.12422. PMID: 34581485 Review.

Hippocampal connectivity with retrosplenial cortex is linked to neocortical tau accumulation and memory function.

Ziontz J, Adams JN, Harrison TM, Baker SL, Jagust WJ.

J Neurosci. 2021 Sep 15:JN-RM-0990-21. doi: 10.1523/JNEUROSCI.0990-21.2021. PMID: 34531286

Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease.

Strom A, Iaccarino L, Edwards L, Lesman-Segev OH, Soleimani-Meigooni DN, Pham J, Baker SL, Landau S, Jagust WJ, Miller BL, Rosen HJ, Gorno-Tempini ML, Rabinovici GD, La Joie R; the Alzheimer’s Disease Neuroimaging Initiative.

Brain. 2021 Aug 9:awab294. doi: 10.1093/brain/awab294. PMID: 34373896

Multiplex Mass Spectrometry Analysis of Amyloid Proteins in Human Plasma for Alzheimer's Disease Diagnosis.

Ni W, Jagust W, Wang D.

J Proteome Res. 2021 Jul 27. doi: 10.1021/acs.jproteome.1c00424. PMID: 34314176

Tau and β-amyloid burden predict actigraphy-measured and self-reported impairment and misperception of human sleep.

Winer JR, Morehouse A, Fenton L, Harrison TM, Ayangma L, Reed M, Kumar S, Baker SL, Jagust WJ, Walker MP.

J Neurosci. 2021 Jul 21:JN-RM-0353-21. doi: 10.1523/JNEUROSCI.0353-21.2021. PMID: 34290080

Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans.

Baker SL, Provost K, Thomas W, Whitman AJ, Janabi M, Schmidt ME, Timmers M, Kolb HC, Rabinovici GD, Jagust WJ.

J Cereb Blood Flow Metab. 2021 Jul 14:271678X211031035. doi: 10.1177/0271678X211031035. PMID: 34259071

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging.

Ossenkoppele R, Smith R, Mattsson-Carlgren N, Groot C, Leuzy A, Strandberg O, Palmqvist S, Olsson T, Jögi J, Stormrud E, Cho H, Ryu YH, Choi JY, Boxer AL, Gorno-Tempini ML, Miller BL, Soleimani-Meigooni D, Iaccarino L, La Joie R, Baker S, Borroni E, Klein G, Pontecorvo MJ, Devous MD Sr, Jagust WJ, Lyoo CH, Rabinovici GD, Hansson O.

JAMA Neurol. 2021 Jun 28. doi: 10.1001/jamaneurol.2021.1858. PMID: 34180956

Alzheimer's Pathology Is Associated with Dedifferentiation of Intrinsic Functional Memory Networks in Aging.

Cassady KE, Adams JN, Chen X, Maass A, Harrison TM, Landau S, Baker S, Jagust W.

Cereb Cortex. 2021 May 25:bhab122. doi: 10.1093/cercor/bhab122. PMID: 34037210

Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach.

Royse SK, Minhas DS, Lopresti BJ, Murphy A, Ward T, Koeppe RA, Bullich S, DeSanti S, Jagust WJ, Landau SM; Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Res Ther. 2021 May 10;13(1):99. doi: 10.1186/s13195-021-00836-1. PMID: 33971965

The changing definition of Alzheimer's disease.

Jagust WJ.

Lancet Neurol. 2021 Apr 29:S1474-4422(21)00077-6. doi: 10.1016/S1474-4422(21)00077-6. PMID: 33933185

Detection of β-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers.

Tosun D, Veitch D, Aisen P, Jack CR Jr, Jagust WJ, Petersen RC, Saykin AJ, Bollinger J, Ovod V, Mawuenyega KG, Bateman RJ, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Weiner MW.

Brain Commun. 2021 Feb 2;3(2):fcab008. doi: 10.1093/braincomms/fcab008. eCollection 2021. PMID: 33842885

Reduced repetition suppression in aging is driven by tau-related hyperactivity in medial temporal lobe.

Adams JN, Maass A, Berron D, Harrison TM, Baker SL, Thomas WP, Stanfill M, Jagust WJ.

J Neurosci. 2021 Mar 16:JN-RM-2504-20. doi: 10.1523/JNEUROSCI.2504-20.2021. PMID: 33731446

Crossed cerebellar diaschisis on 18F-FDG PET: Frequency across neurodegenerative syndromes and association with 11C-PIB and 18F-Flortaucipir.

Provost K, La Joie R, Strom A, Iaccarino L, Edwards L, Mellinger TJ, Pham J, Baker SL, Miller BL, Jagust WJ, Rabinovici GD.

J Cereb Blood Flow Metab. 2021 Mar 10:271678X211001216. doi: 10.1177/0271678X211001216. PMID: 33691512

Integrating events in the disintegration of Alzheimer's disease.

Jagust W.

Brain. 2021 Feb 12;144(1):11-14. doi: 10.1093/brain/awaa402. PMID: 33578426

Temporal Dynamics of Beta-amyloid Accumulation in Aging and Alzheimer's Disease.

Jagust WJ, Landau SM; Alzheimer’s Disease Neuroimaging Initiative.

Neurology. 2021 Jan 6:10.1212/WNL.0000000000011524. doi: 10.1212/WNL.0000000000011524. PMID: 33408147

Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts.

Provost K, Iaccarino L, Soleimani-Meigooni DN, Baker S, Edwards L, Eichenlaub U, Hansson O, Jagust W, Janabi M, La Joie R, Lesman-Segev O, Mellinger TJ, Miller BL, Ossenkoppele R, Pham J, Smith R, Sonni I, Strom A, Mattsson-Carlgren N, Rabinovici GD; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Eur J Nucl Med Mol Imaging. 2021 Jan 4. doi: 10.1007/s00259-020-05152-8. PMID: 33398408

Alzheimer Disease Spectrum: Syndrome and Etiology from Clinical and PET Imaging Perspectives.

Knopman DS, Jagust WJ.

Neurology. 2020 Dec 22:10.1212/WNL.0000000000011415. doi: 10.1212/WNL.0000000000011415. PMID: 33361254

Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults.

Harrison TM, Du R, Klencklen G, Baker SL, Jagust WJ.

Alzheimers Dement. 2020 Dec 15. doi: 10.1002/alz.12249. Online ahead of print. PMID: 33325068

Evaluation of a visual interpretation method for tau-PET with 18F-flortaucipir.

Sonni I, Lesman Segev OH, Baker SL, Iaccarino L, Korman D, Rabinovici GD, Jagust WJ, Landau SM, La Joie R; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (Amst). 2020 Nov 28;12(1):e12133. doi: 10.1002/dad2.12133. eCollection 2020. PMID: 33313377

Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET.

La Joie R, Visani AV, Lesman-Segev OH, Baker SL, Edwards L, Iaccarino L, Soleimani-Meigooni DN, Mellinger T, Janabi M, Miller ZA, Perry DC, Pham J, Strom A, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2020 Dec 1:10.1212/WNL.0000000000011270. doi: 10.1212/WNL.0000000000011270. PMID: 33262228

Diagnostic Accuracy of Amyloid versus FDG PET in Autopsy-Confirmed Dementia.

Lesman-Segev OH, La Joie R, Iaccarino L, Lobach I, Rosen HJ, Seo SW, Janabi M, Baker SL, Edwards L, Pham J, Olichney J, Boxer A, Huang E, Gorno-Tempini M, DeCarli C, Hepker M, Hwang JL, Miller BL, Spina S, Grinberg LT, Seeley WW, Jagust WJ, Rabinovici GD.

Ann Neurol. 2020 Nov 20. doi: 10.1002/ana.25968. PMID: 33219525

Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults.

Chen X, Cassady K, Adams JN, Harrison TM, Baker SL, Jagust WJ.

J Neurosci. 2020 Nov 20:JN-RM-2111-20. doi: 10.1523/JNEUROSCI.2111-20.2020. PMID: 33219003

Conscientiousness is associated with less amyloid deposition in cognitively normal aging.

Yoon B, Baker SL, Korman D, Tennant VR, Harrison TM, Landau S, Jagust WJ.

Psychol Aging. 2020 Nov;35(7):993-999. doi: 10.1037/pag0000582. PMID: 33166168

18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases.

Soleimani-Meigooni DN, Iaccarino L, La Joie R, Baker S, Bourakova V, Boxer AL, Edwards L, Eser R, Gorno-Tempini ML, Jagust WJ, Janabi M, Kramer JH, Lesman-Segev OH, Mellinger T, Miller BL, Pham J, Rosen HJ, Spina S, Seeley WW, Strom A, Grinberg LT, Rabinovici GD.

Brain. 2020 Nov 3:awaa276. doi: 10.1093/brain/awaa276. PMID: 33141172

Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years.

Winer JR, Mander BA, Kumar S, Reed M, Baker SL, Jagust WJ, Walker MP.

Curr Biol. 2020 Aug 28:S0960-9822(20)31171-4. doi: 10.1016/j.cub.2020.08.017. PMID: 32888482

Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum.

Iaccarino L, La Joie R, Edwards L, Strom A, Schonhaut DR, Ossenkoppele R, Pham J, Mellinger T, Janabi M, Baker SL, Soleimani-Meigooni D, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD.

Cereb Cortex. 2020 Aug 18:bhaa184. doi: 10.1093/cercor/bhaa184. PMID: 32808011

Normalization of CSF pTau measurement by Aβ40 improves its performance as a biomarker of Alzheimer's disease.

Guo T, Korman D, La Joie R, Shaw LM, Trojanowski JQ, Jagust WJ, Landau SM; Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Res Ther. 2020 Aug 15;12(1):97. doi: 10.1186/s13195-020-00665-8. PMID: 32799929

Association of CSF Aβ, amyloid PET and cognition in cognitively unimpaired elderly adults.

Guo T, Shaw LM, Trojanowski JQ, Jagust WJ, Landau SM; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2020 Aug 5:10.1212/WNL.0000000000010596. doi: 10.1212/WNL.0000000000010596. PMID: 32759202

Association of vascular brain injury, neurodegeneration, amyloid and cognitive trajectory.

Han JW, Maillard P, Harvey D, Fletcher E, Martinez O, Johnson DK, Olichney JM, Farias ST, Villeneuve S, Jagust W, Mungas D, DeCarli C.

Neurology. 2020 Jul 30:10.1212/WNL.0000000000010531. doi: 10.1212/WNL.0000000000010531. PMID: 32732300

Longitudinal Cognitive and Biomarker Measurements Support a Unidirectional Pathway in Alzheimer's Disease Pathophysiology.

Guo T, Korman D, Baker SL, Landau SM, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Biol Psychiatry. 2020 Jul 12:S0006-3223(20)31739-X. doi: 10.1016/j.biopsych.2020.06.029. PMID: 32919611

Longitudinal structural and metabolic changes in frontotemporal dementia.

Bejanin A, Tammewar G, Marx G, Cobigo Y, Iaccarino L, Kornak J, Staffaroni AM, Dickerson BC, Boeve BF, Knopman DS, Gorno-Tempini M, Miller BL, Jagust WJ, Boxer AL, Rosen HJ, Rabinovici GD.

Neurology. 2020 Jun 26. pii: 10.1212/WNL.0000000000009760. doi: 10.1212/WNL.0000000000009760. PMID: 32591470

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.

Raghavan NS, Dumitrescu L, Mormino E, Mahoney ER, Lee AJ, Gao Y, Bilgel M, Goldstein D, Harrison T, Engelman CD, Saykin AJ, Whelan CD, Liu JZ, Jagust W, Albert M, Johnson SC, Yang HS, Johnson K, Aisen P, Resnick SM, Sperling R, De Jager PL, Schneider J, Bennett DA, Schrag M, Vardarajan B, Hohman TJ, Mayeux R; Alzheimer’s Disease Neuroimaging Initiative.

JAMA Neurol. 2020 Jun 22. doi: 10.1001/jamaneurol.2020.1760. PMID: 32568366

Relevance of biomarkers across different neurodegenerative diseases.

Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, Mattsson-Carlgren N, Ashton NJ, Hanrieder J, Zetterberg H, Schöll M, Paterson RW.

Alzheimers Res Ther. 2020 May 13;12(1):56. doi: 10.1186/s13195-020-00601-w. PMID: 32404143

Imaging Tau Pathology-The Next Step.

Jagust WJ.

JAMA Neurol. 2020 Apr 27. doi: 10.1001/jamaneurol.2020.0520. PMID: 32338712

Imaging biomarkers in neurodegeneration: current and future practices.

Young PNE, Estarellas M, Coomans E, Srikrishna M, Beaumont H, Maass A, Venkataraman AV, Lissaman R, Jiménez D, Betts MJ, McGlinchey E, Berron D, O'Connor A, Fox NC, Pereira JB, Jagust W, Carter SF, Paterson RW, Schöll M.

Alzheimers Res Ther. 2020 Apr 27;12(1):49. doi: 10.1186/s13195-020-00612-7. Review. PMID: 32340618

Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline.

Ranasinghe KG, Cha J, Iaccarino L, Hinkley LB, Beagle AJ, Pham J, Jagust WJ, Miller BL, Rankin KP, Rabinovici GD, Vossel KA, Nagarajan SS.

Sci Transl Med. 2020 Mar 11;12(534). pii: eaaz4069. doi: 10.1126/scitranslmed.aaz4069. PMID: 32161102

Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults.

Guo T, Landau SM, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2020 Mar 18. pii: 10.1212/WNL.0000000000009216. doi: 10.1212/WNL.0000000000009216. PMID: 32188766

Analytical and Clinical Performance of Amyloid-Beta Peptides Measurements in CSF of ADNIGO/2 Participants by an LC-MS/MS Reference Method.

Korecka M, Figurski MJ, Landau SM, Brylska M, Alexander J, Blennow K, Zetterberg H, Jagust WJ, Trojanowski JQ, Shaw LM; Alzheimer’s Disease Neuroimaging Initiative.

Clin Chem. 2020 Feb 22. pii: hvaa012. doi: 10.1093/clinchem/hvaa012. PMID: 32087019

Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease.

Giorgio J, Landau SM, Jagust WJ, Tino P, Kourtzi Z; Alzheimer's Disease Neuroimaging Initiative.

Neuroimage Clin. 2020 Jan 26;26:102199. doi: 10.1016/j.nicl.2020.102199. PMID: 32106025

Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults.

Pereira JB, Harrison TM, La Joie R, Baker SL, Jagust WJ.

Eur J Nucl Med Mol Imaging. 2020 Jan 8. doi: 10.1007/s00259-019-04669-x. PMID: 31915896

Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET.

La Joie R, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, Chaudhary K, Edwards L, Iaccarino L, Janabi M, Lesman-Segev OH, Miller ZA, Perry DC, O'Neil JP, Pham J, Rojas JC, Rosen HJ, Seeley WW, Tsai RM, Miller BL, Jagust WJ, Rabinovici GD.

Sci Transl Med. 2020 Jan 1;12(524). pii: eaau5732. doi: 10.1126/scitranslmed.aau5732. PMID: 31894103

What are the threats to successful brain and cognitive aging?

Gallagher M, Okonkwo OC, Resnick SM, Jagust WJ, Benzinger TLS, Rapp PR.

Neurobiol Aging. 2019 Nov;83:130-134. doi: 10.1016/j.neurobiolaging.2019.04.016. PMID: 31732016

Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.

Lesman-Segev OH, La Joie R, Stephens ML, Sonni I, Tsai R, Bourakova V, Visani AV, Edwards L, O'Neil JP, Baker SL, Gardner RC, Janabi M, Chaudhary K, Perry DC, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD.

Neuroimage Clin. 2019 Oct 17;24:102025. doi: 10.1016/j.nicl.2019.102025. PMID: 31670152

Tau deposition is associated with functional isolation of the hippocampus in aging.

Harrison TM, Maass A, Adams JN, Du R, Baker SL, Jagust WJ.

Nat Commun. 2019 Oct 25;10(1):4900. doi: 10.1038/s41467-019-12921-z.PMID: 31653847

Cortical tau deposition follows patterns of entorhinal functional connectivity in aging.

Adams JN, Maass A, Harrison TM, Baker SL, Jagust WJ.

Elife. 2019 Sep 2;8. pii: e49132. doi: 10.7554/eLife.49132.

Sleep as a potential biomarker of tau and β-amyloid burden in the human brain.

Winer JR, Mander BA, Helfrich RF, Maass A, Harrison TM, Baker SL, Knight RT, Jagust WJ, Walker MP.

J Neurosci. 2019 Jun 17. pii: 0503-19. doi: 10.1523/JNEUROSCI.0503-19.2019. PMID: 31209175

Development of a mnemonic discrimination task using naturalistic stimuli with applications to aging and preclinical Alzheimer's disease.

Leal SL, Ferguson LA, Harrison TM, Jagust WJ.

Learn Mem . 2019 Jun 17;26(7):219-228. doi: 10.1101/lm.048967.118. Print 2019 Jul.PMID: 31209116

Alzheimer's pathology targets distinct memory networks in the ageing brain.

Maass A, Berron D, Harrison TM, Adams JN, La Joie R, Baker S, Mellinger T, Bell RK, Swinnerton K, Inglis B, Rabinovici GD, Düzel E, Jagust WJ.

Brain. 2019 Jun 14. pii: awz154. doi: 10.1093/brain/awz154. PMID: 31199481

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain.

Ossenkoppele R, Iaccarino L, Schonhaut DR, Brown JA, La Joie R, O'Neil JP, Janabi M, Baker SL, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW, Jagust WJ, Rabinovici GD.

Neuroimage Clin. 2019 May 2;23:101848. doi: 10.1016/j.nicl.2019.101848. PMID: 31077982

Effect of off-target binding on 18F-Flortaucipir variability in healthy controls across the lifespan.

Baker SL, Harrison TM, Maaß A, La Joie R, Jagust W.

J Nucl Med. 2019 Mar 15. pii: jnumed.118.224113. doi: 10.2967/jnumed.118.224113. PMID: 30877180

Vascular Burden Score Impacts Cognition Independent of Amyloid PET and MRI Measures of Alzheimer's Disease and Vascular Brain Injury.

DeCarli C, Villeneuve S, Maillard P, Harvey D, Singh B, Carmichael O, Fletcher E, Olichney J, Farias S, Jagust W, Reed B, Mungas D.J

Alzheimers Dis. 2019 Feb 11. doi: 10.3233/JAD-180965. PMID: 30775991

Dopaminergic mechanisms underlying normal variation in trait anxiety.

Berry AS, White RL 3rd, Furman DJ, Naskolnakorn JR, Shah VD, D'Esposito M, Jagust WJ.

J Neurosci. 2019 Feb 8. pii: 2382-18. doi: 10.1523/JNEUROSCI.2382-18.2019. PMID: 30737306

18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.

Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD.

Alzheimers Res Ther. 2019 Jan 31;11(1):13. doi: 10.1186/s13195-019-0470-7.PMID: 30704514

“Alzheimer’s disease” is neither “Alzheimer’s clinical syndrome” nor “dementia”.

Jagust W, Jack CR Jr, Bennett DA, Blennow K, Haeberlein SB, Holtzman DM, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Sperling R.

Alzheimers Dement. 2019 Jan;15(1):153-157. doi: 10.1016/j.jalz.2018.11.002. No abstract available. PMID: 30642435

Longitudinal tau accumulation and atrophy in aging and Alzheimer's disease.

Harrison TM, La Joie R, Maass A, Baker SL, Swinnerton K, Fenton L, Mellinger TJ, Edwards L, Pham J, Miller BL, Rabinovici GD, Jagust WJ.

Ann Neurol. 2018 Dec 31. doi: 10.1002/ana.25406. [Epub ahead of print]PMID: 30597624

Age-related variability in decision-making: Insights from neurochemistry.

Berry AS, Jagust WJ, Hsu M.

Cogn Affect Behav Neurosci. 2018 Dec 10. doi: 10.3758/s13415-018-00678-9. [Epub ahead of print]PMID: 30536205

Biomarkers for tau pathology.

Schöll M, Maass A, Mattsson N, Ashton NJ, Blennow K, Zetterberg H, Jagust W.

Mol Cell Neurosci. 2018 Dec 7. pii: S1044-7431(18)30233-1. doi: 10.1016/j.mcn.2018.12.001. [Epub ahead of print] Review.PMID: 30529601

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.

Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C Jr, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe VJ, Masters CL, Mathis CA, McLean CL, Miller BL, Mungas D, O'Neil JP, Olichney JM, Parisi JE, Petersen RC, Rosen HJ, Rowe CC, Spina S, Vemuri P, Villemagne VL, Murray ME, Rabinovici GD.

Alzheimers Dement. 2018 Oct 19. pii: S1552-5260(18)33523-4. doi: 10.1016/j.jalz.2018.09.001. [Epub ahead of print]PMID: 30347188

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.

Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2018 Oct 12. pii: S1552-5260(18)33514-3. doi: 10.1016/j.jalz.2018.08.005. [Epub ahead of print] Review.PMID: 30321505

Imaging the evolution and pathophysiology of Alzheimer disease.

Jagust W.

Nat Rev Neurosci. 2018 Sep 28. doi: 10.1038/s41583-018-0067-3. [Epub ahead of print] Review.

Scan-time Corrections for 80-100 Minute Standardized Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging.

He M, Baker SL, Shah VD, Lockhart SN, Jagust WJ.

IEEE Trans Med Imaging. 2018 Sep 17. doi: 10.1109/TMI.2018.2870441. [Epub ahead of print]

Spatially Adaptive Varying Correlation Analysis for Multimodal Neuroimaging Data.

Li L, Kang J, Lockhart SN, Adams J, Jagust WJ.

IEEE Trans Med Imaging. 2018 Jul 18. doi: 10.1109/TMI.2018.2857221. [Epub ahead of print]

A New Tool for Clinical Neuroscience-Synaptic Imaging.

Mormino EC, Jagust WJ.

JAMA Neurol. 2018 Jul 16. doi: 10.1001/jamaneurol.2018.1643. [Epub ahead of print] 

Assessment of Extent and Role of Tau in Subcortical Vascular Cognitive Impairment Using 18F-AV1451 Positron Emission Tomography Imaging.

Kim HJ, Park S, Cho H, Jang YK, San Lee J, Jang H, Kim Y, Kim KW, Ryu YH, Choi JY, Moon SH, Weiner MW, Jagust WJ, Rabinovici GD, DeCarli C, Lyoo CH, Na DL, Seo SW.

JAMA Neurol. 2018 May 14. doi: 10.1001/jamaneurol.2018.0975. [Epub ahead of print]

The Influence of Dopamine on Cognitive Flexibility Is Mediated by Functional Connectivity in Young but Not Older Adults.

Berry AS, Shah VD, Jagust WJ.

J Cogn Neurosci. 2018 May 23:1-15. doi: 10.1162/jocn_a_01286. [Epub ahead of print]

Subthreshold amyloid predicts tau deposition in aging.

Leal SL, Lockhart SN, Maass A, Bell RK, Jagust WJ.

J Neurosci. 2018 Apr 23. pii: 0485-18. doi: 10.1523/JNEUROSCI.0485-18.2018. [Epub ahead of print]

Brain morphology, cognition, and β-amyloid in older adults with superior memory performance.

Harrison TM, Maass A, Baker SL, Jagust WJ.

Neurobiol Aging. 2018 Mar 27;67:162-170. doi: 10.1016/j.neurobiolaging.2018.03.024. [Epub ahead of print]

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.

Jack CR Jr., Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors.

Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018.

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Mattsson N, Groot C, Jansen WJ, Landau S, Villemagne V, Et al.

Alzheimers Dement. 2018 Mar 27. pii: S1552-5260(18)30063-3. doi: 10.1016/j.jalz.2018.02.009. [Epub ahead of print]

Memory decline accompanies subthreshold amyloid accumulation

Landau SM, Horng A, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2018 Mar 23. pii: 10.1212/WNL.0000000000005354. doi: 10.1212/WNL.0000000000005354. [Epub ahead of print]

Metabolic brain networks in aging and preclinical Alzheimer's disease

Arnemann KL, Stöber F, Narayan S, Rabinovici GD, Jagust WJ.

Neuroimage Clin. 2017 Dec 28;17:987-999. doi: 10.1016/j.nicl.2017.12.037. eCollection 2018.

Following the pathway to Alzheimer's disease

Jagust W

Nat Neurosci. 2018 Feb 23. doi: 10.1038/s41593-018-0085-5. [Epub ahead of print]

Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.

Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML.

JAMA Neurol. 2018 Jan 8. doi: 10.1001/jamaneurol.2017.4309. [Epub ahead of print]

Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting.

Helfrich RF, Mander BA, Jagust WJ, Knight RT, Walker MP.

Neuron. 2018 Jan 3;97(1):221-230.e4. doi: 10.1016/j.neuron.2017.11.020. Epub 2017 Dec 14.

Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample.

La Joie R, Bejanin A, Fagan AM, Ayakta N, Baker SL, Bourakova V, Boxer AL, Cha J, Karydas A, Jerome G, Maass A, Mensing A, Miller ZA, O'Neil JP, Pham J, Rosen HJ, Tsai R, Visani AV, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2017 Dec 27. pii: 10.1212/WNL.0000000000004860. doi: 10.1212/WNL.0000000000004860. [Epub ahead of print]

Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease.

Winer JR, Maass A, Pressman P, Stiver J, Schonhaut DR, Baker SL, Kramer J, Rabinovici GD, Jagust WJ.

JAMA Neurol. 2017 Dec 11. doi: 10.1001/jamaneurol.2017.3713. [Epub ahead of print]

Entorhinal tau pathology, episodic memory decline and neurodegeneration in aging.

Maass A, Lockhart SN, Harrison TM, Bell RK, Mellinger T, Swinnerton K, Baker SL, Rabinovici GD, Jagust WJ.

J Neurosci. 2017 Nov 30. pii: 2028-17. doi: 10.1523/JNEUROSCI.2028-17.2017. [Epub ahead of print]

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.

Neuroimage Clin. 2017 Sep 25;17:452-464. doi: 10.1016/j.nicl.2017.09.016. eCollection 2018

Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD.

Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia.

Eur J Nucl Med Mol Imaging. 2017 Nov 16. doi: 10.1007/s00259-017-3876-0. [Epub ahead of print]

Jang YK, Lyoo CH, Park S, Oh SJ, Cho H, Oh M, Ryu YH, Choi JY, Rabinovici GD, Kim HJ, Moon SH, Jang H, Lee JS, Jagust WJ, Na DL, Kim JS, Seo SW.

Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data.

Data Brief. 2017 Oct 16;15:648-657. doi: 10.1016/j.dib.2017.10.024. eCollection 2017 Dec.

Baker SL, Maass A, Jagust WJ.

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity.

Nat Commun. 2017 Oct 31;8(1):1214. doi: 10.1038/s41467-017-01150-x.

Palmqvist S, Schöll M, Strandberg O, Mattsson N, Stomrud E, Zetterberg H, Blennow K, Landau S, Jagust W, Hansson O.

White matter structure in older adults moderates the benefit of sleep spindles on motor memory consolidation.

J Neurosci. 2017 Oct 30. pii: 3033-16. doi: 10.1523/JNEUROSCI.3033-16.2017. [Epub ahead of print]

Mander BA, Zhu AH, Lindquist JR, Villeneuve S, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust W, Walker MP.

Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.

Brain. 2017 Oct 7. doi: 10.1093/brain/awx243. [Epub ahead of print]

Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, Ayakta N, Cantwell A, Janabi M, Lauriola M, O'Neil JP, Gorno-Tempini ML, Miller ZA, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD.

Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but not Dopamine Release.

Neuropsychopharmacology. 2017 Aug 17. doi: 10.1038/npp.2017.180. [Epub ahead of print]

Berry AS, Shah VD, Furman DJ, White RL, Baker SL, O'Neil JP, Janabi M, D'Esposito M, Jagust WJ

Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.

Biol Psychiatry. 2017 Jun 16. pii: S0006-3223(17)31672-4.   doi: 10.1016/j.biopsych.2017.06.010. [Epub ahead of print]

van Holst RJ, Sescousse G, Janssen LK, Janssen M, Berry AS, Jagust WJ, Cools R.

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's Disease.

Neuroimage. 2017 Jun 3. pii: S1053-8119(17)30458-5. doi: 10.1016/j.neuroimage.2017.05.058. [Epub ahead of print]

Maass A, Landau S, Baker SL, Horng A, Lockhart SN, Joie R, Rabinovici GD, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.

JAMA Neurol. 2017 Mar 20. doi: 10.1001/jamaneurol.2016.5349. [Epub ahead of print]

Schreiber S, Schreiber F, Lockhart SN, Horng A, Bejanin A, Landau SM, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative

Tau and Beta-amyloid are associated with medial temporal lobe structure, function and memory encoding in normal aging.

J Neurosci. 2017 Feb 17. pii: 3769-16. doi: 10.1523/JNEUROSCI.3769-16.2017. [Epub ahead of print] PMID: 28213439

Marks SM, Lockhart SN, Baker SL, Jagust W

Elevated 18 F-AV-1451 PET tracer uptake detected in incidental imaging findings.

Neurology. 2017 Feb 10. pii: 10.1212/WNL.0000000000003724. doi: 10.1212/WNL.0000000000003724. [Epub ahead of print]

Lockhart SN, Ayakta N, Winer JR, La Joie R, Rabinovici GD, Jagust WJ.

Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline.

Elife. 2017 Feb 8;6. pii: e22978. doi: 10.7554/eLife.22978. [Epub ahead of print]

Leal SL, Landau SM, Bell RK, Jagust WJ.

Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.

Neurology. 2017 Jan 27. pii: 10.1212/WNL.0000000000003636. doi: 10.1212/WNL.0000000000003636. [Epub ahead of print]

Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD.

Aging affects dopaminergic neural mechanisms of cognitive flexibility.

J Neurosci. 2016 Nov 2. pii: 0626-16. [Epub ahead of print]

Berry AS, Shah VD, Baker SL, Vogel JW, O’Neil JP, Janabi M, Schwimmer HD, Marks SM, Jagust WJ.

Reference tissue-based kinetic evaluation of 18F-AV-1451 in aging and dementia.

J Nucl Med. 2016 Sep 1. pii: jnumed.116.175273. [Epub ahead of print]

Baker SL, Lockhart SN, Price JC, He M, Huesman RH, Schonhaut D, Faria J, Rabinovici G, Jagust WJ.

Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer’s disease.

Hum Brain Mapp. 2016 Jul 13. doi: 10.1002/hbm.23305. [Epub ahead of print]

Ballarini T, Iaccarino L, Magnani G, Ayakta N, Miller BL, Jagust WJ, Gorno-Tempini ML, D Rabinovici G, Perani D.

Early life sets the stage for aging.

Proc Natl Acad Sci U S A. 2016 Jul 19. pii: 201609720. [Epub ahead of print]

Jagust WJ.

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer’s Disease Patients Measured Using [18F] THK-5351.

PLoS One. 2016 Jun 29;11(6):e0158460. doi: 10.1371/journal.pone.0158460. eCollection 2016.

Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ.

Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer’s disease.

Brain. 2016 Jun 29. pii: aww159. [Epub ahead of print]

Chételat G, Ossenkoppele R, Villemagne VL, Perrotin A, Landeau B, Mézenge F, Jagust WJ, Dore V, Miller BL, Egret S, Seeley WW, van der Flier WM, La Joie R, Ames D, van Berckel BN, Scheltens P, Barkhof F, Rowe CC, Masters CL, de La Sayette V, Bouwman F, Rabinovici GD.

Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer’s Disease?

Trends Neurosci. 2016 Jun 17. pii: S0166-2236(16)30037-6. doi: 10.1016/j.tins.2016.05.002. [Epub ahead of print] Review.

Mander BA, Winer J, Jagust WJ, Walker MP.

Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology.

Neurology. 2016 Apr 15. pii: 10.1212/WNL.0000000000002683. [Epub ahead of print]

Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative.

Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI.

Neurology. 2016 Mar 11. pii: 10.1212/WNL.0000000000002576. [Epub ahead of print]

Landau SM, Horng A, Fero A, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease.

Brain. 2016 Mar 8. pii: aww027. [Epub ahead of print]

Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O’Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD

PET Imaging of Tau Deposition in the Aging Human Brain.

Neuron. 2016 Mar 2; 89, 971–982; doi: 10.1016/j.neuron.2016.01.028

Michael Schöll, Samuel N Lockhart, Daniel R Schonhaut, Henry D Schwimmer, Gil D Rabinovici, William J Jagust Correspondence, Michael Schö Ll, James P O ‘neil, Mustafa Janabi, Rik Ossenkoppele, Suzanne L Baker, Jacob W Vogel, Jamie Faria, William J Jagust

Braak ROIs: Supplimental info

Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment.

J Alzheimers Dis. 2016 Jan 19;50(4):1125-35. doi: 10.3233/JAD-150841.

Jung NY, Han CE, Kim HJ, Yoo SW, Kim HJ, Kim EJ, Na DL, Lockhart SN, Jagust WJ, Seong JK, Seo SW

Modulation of Impulsivity and Reward Sensitivity in Intertemporal Choice by Striatal and Midbrain Dopamine Synthesis in Healthy Adults.

J Neurophysiol. 2015 Dec 16:jn.00261.2015. doi: 10.1152/jn.00261.2015.

Smith CT, Wallace DL, Dang LC, Aarts E, Jagust WJ, D’Esposito M, Boettiger CA

Is amyloid-β harmful to the brain? Insights from human imaging studies.

Brain. 2015 Nov 27. pii: awv326.

Jagust, WJ

Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-β-Positive Subjects in the Alzheimer’s Disease Continuum.

Neurodegener Dis. 2016;16(1-2):87-94. doi: 10.1159/000439257. Epub 2015 Nov 12.

Tosun D, Schuff N, Jagust W, Weiner MW; Alzheimer’’s Disease Neuroimaging Initiative.

Comparison of Visual and Quantitative Florbetapir F 18 Positron Emission Tomography Analysis in Predicting Mild Cognitive Impairment Outcomes.

JAMA Neurol. 2015 Oct 1;72(10):1183-90. doi: 10.1001/jamaneurol.2015.1633.

Schreiber S, Landau SM, Fero A, Schreiber F, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Regional brain hypometabolism is unrelated to regional amyloid plaque burden.

Brain. 2015 Dec;138(Pt 12):3734-46. doi: 10.1093/brain/awv278. Epub 2015 Sep 29.

Altmann A, Ng B, Landau SM, Jagust WJ, Greicius MD; Alzheimer’s Disease Neuroimaging Initiative.

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer’s disease.

Hum Brain Mapp. 2015 Nov;36(11):4421-37. doi: 10.1002/hbm.22927. Epub 2015 Aug 11.

Ossenkoppele R, Cohn-Sheehy BI, La Joie R, Vogel JW, Möller C, Lehmann M, van Berckel BN, Seeley WW, Pijnenburg YA, Gorno-Tempini ML,Kramer JH, Barkhof F, Rosen HJ, van der Flier WM, Jagust WJ, Miller BL, Scheltens P, Rabinovici GD

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP.

Brain. 2015 Oct;138(Pt 10):3076-88. doi: 10.1093/brain/awv231. Epub 2015 Aug 11.

Ramanan VK, Risacher SL, Nho K, Kim S, Shen L, McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S, Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, Jagust WJ, Weiner MW, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer’s disease variants.

Neurobiol Aging. 2015 Oct;36(10):2678-86. doi: 10.1016/j.neurobiolaging.2015.06.029. Epub 2015 Jul 16.

Lehmann M, Madison C, Ghosh PM, Miller ZA, Greicius MD, Kramer JH, Coppola G, Miller BL, Jagust WJ, Gorno-Tempini ML, Seeley WW, Rabinovici GD

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.

Neurol Genet. 2015 Oct 15;1(3):e22. doi: 10.1212/NXG.0000000000000022. eCollection 2015 Oct.

Lazaris A, Hwang KS, Goukasian N, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin AJ, Shaw LM, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG; Alzheimer’s Disease Neuroimaging Initiative.

The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features.

Brain. 2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2.

Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, Joie RL, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD

The Alzheimer’s Disease Neuroimaging Initiative 2 PET Core: 2015.

The Alzheimer’s Disease Neuroimaging Initiative 2 PET Core: 2015

Jagust WJ, Landau SM, Koeppe RA, Reiman EM, Chen K, Mathis CA, Price JC, Foster NL, Wang AY

Impact of the Alzheimer’s Disease Neuroimaging Initiative, 2004 to 2014.

Alzheimers Dement. 2015 Jul;11(7):865-84. doi: 10.1016/j.jalz.2015.04.005. Review.

Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Donohue MC, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw L, Thompson PM, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative.

Amyloid in dementia associated with familial FTLD: not an innocent bystander.

Neurocase. 2016 Feb;22(1):76-83. doi: 10.1080/13554794.2015.1046458. Epub 2015 Jun 4.

Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ

2014 Update of the Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception.

Alzheimers Dement. 2015 Jun;11(6):e1-120. doi: 10.1016/j.jalz.2014.11.001.

Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Green RC, Harvey D, Jack CR, Jagust W, Luthman J, Morris JC, Petersen RC, Saykin AJ, Shaw L, Shen L, Schwarz A, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative.

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4035. [Epub ahead of print]

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.

JAMA. 2015 May 19;313(19):1939-49. doi: 10.1001/jama.2015.4669.

Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BN, Scheltens P, Visser PJ; Amyloid PET Study Group, Verfaillie SC, Zwan MD, Adriaanse SM, Lammertsma AA, Barkhof F, Jagust WJ, Miller BL, Rosen HJ, Landau SM, Villemagne VL, Rowe CC, Lee DY, Na DL, Seo SW, Sarazin M, Roe CM, Sabri O, Barthel H, Koglin N, Hodges J, Leyton CE, Vandenberghe R, van Laere K, Drzezga A, Forster S, Grimmer T, Sánchez-Juan P, Carril JM, Mok V, Camus V, Klunk WE, Cohen AD, Meyer PT, Hellwig S, Newberg A, Frederiksen KS, Fleisher AS, Mintun MA, Wolk DA, Nordberg A, Rinne JO, Chételat G, Lleo A, Blesa R, Fortea J, Madsen K, Rodrigue KM, Brooks DJ

Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods.

Appetite. 2015 May 8;92:74-80. doi: 10.1016/j.appet.2015.05.004. [Epub ahead of print]

Wallace DL, Aarts E, d’Oleire Uquillas F, Dang LC, Greer SM, Jagust WJ, D’Esposito M

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

Brain. 2015 Jul;138(Pt 7):2020-33. doi: 10.1093/brain/awv112. Epub 2015 May 6.

Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen H, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin L, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust WJ

Clustering-initiated factor analysis application for tissue classification in dynamic brain positron emission tomography

J Cereb Blood Flow Metab. 2015 Apr 22. doi: 10.1038/jcbfm.2015.69. [Epub ahead of print]

Boutchko R, Mitra D, Baker SL, Jagust WJ, Gullberg GT

Measurement of longitudinal Aβ change with 18F florbetapir PET and standard uptake value ratios

J Nucl Med. 2015 Apr;56(4):567-74

Landau SM, Fero A, Baker SL, Koeppe RA, Mintun M, Chen K, Reiman E, Jagust W

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4035. [Epub ahead of print]

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

Dopamine and the cognitive downside of a promised bonus

Psychol Sci. 2014 Apr;25(4):1003-9

Aarts E, Wallace DL, Dang LC, Jagust WJ, Cools R, D’Esposito M

Neural compensation in older people with brain amyloid-β deposition

Nat Neurosci. 2014 Oct;17(10):1316-8

Elman JA, Oh H, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ

Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability

Cereb Cortex. 2014 Nov 7. pii: bhu259. [Epub ahead of print]

Elman JA, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ

Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers

Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1398-407

Landau SM, Thomas BA, Thurfjell L, Schmidt M, Margolin R, Mintun M, Pontecorvo M, Baker SL, Jagust WJ

Associations between serum cholesterol levels and cerebral amyloidosis

JAMA Neurology 71:195-200, 2014

Reed B, Villeneuve S, Mack W, DeCarli C, Chui HC, Jagust WJ

Cortical thickness mediates the effect of b-amyloid on episodic memory

Neurology 82:761-7, 2014

Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N, Mack W, Mungas D, Chui HC, DeCarli C, Weiner MW, Jagust WJ

Vascular risk and Ab interact to reduct cortical thickness in AD vulnerable brain regions

Neurology 83: 40-47, 2014

Villeneuve S, Reed BR, Madison CM, Wirth M, Marchant NL, Kriger S, Mack WJ, Sanossian N, DeCarli C, Chui HC, Weiner MW, Jagust WJ

Dorsal striatal dopamine, food preference and health perception in humans

PloS One May 7 9(5):e96319, 2014

Wallace DL, Aarts E, Dang LC, Greer SM, Jagust WJ, D’Esposito M

Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal adults

Neurobiology of Aging 35:1873-1882, 2014

Wirth M, Haase CM, Villeneuve S, Vogel J, Jagust WJ

Gene-Environment interactions: Lifetime cognitive activity, ApoE genotype and beta-amyloid burden

Journal of Neuroscience 34: 8612-8617, 2014

Wirth M, Villeneuve S, La Joie R, Marks SM, Jagust WJ

Vulnerable neural systems and the borderland of brain aging and neurodegeneration

Neuron 77:219-234, 2013

Jagust, W.

Comparing Positron Emission Tomography Imaging and Cerebrospinal Fluid Measurements of b-Amyloid

Ann Neurol. 2013 Dec;74(6):826-36

Landau SM, Lu M, Joshi AD, Pontecorvo M, Mintun MA, Trojanowski JQ, Shaw LM, Jagust WJ for the Alzheimer’s Disease Neuroimaging Initiative

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease

Brain. 2013 Mar;136(Pt 3):844-58

Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

Journal of Neurology, Neurosurgery and Psychiatry Aug 21, 2013

Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O’Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD

Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer’s disease.

Proceedings of the National Academy of Sciences USA, 110:11606-11611, 2013

Lehmann M, Madison CM, Ghosh PM, Seeley WW, Mormino E, Greicius MD, Gorno-Tempini ML, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD

Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging

Nature Neuroscience 16:357-364, 2013.

Mander BA, Rao V, Lu B, Saletin JM, Lindquist JR, Ancoli-Israel S, Jagust W, Walker MP.

Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults

Cerebral Cortex July 30, 2013

Mander BA, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

The aging brain and cognition: Contribution of vascular injury and Ab to mild cognitive dysfunction.

JAMA Neurology Apri 1, 2013

Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ

Association of gray matter atrophy with age, b-amyloid, and cognition in aging

Cerebral Cortex Feb 6 2013

Oh H, Madison C, Villeneuve S, Markley C, Jagust WJ

Frontotemporal Network Connectivity during Memory Encoding Is Increased with Aging and Disrupted by Beta-Amyloid.

J Neurosci. 2013 Nov 20

Oh H, Jagust WJ.

Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people

JAMA Neurology 70:1512-1519, 2013

Wirth M, Villeneuve S, Haase CM, Madison CM, Oh H, Landau SM, Rabinovici GD, Jagust WJ

Dopamine supports coupling of attention-related networks

Journal of Neuroscience, 32(28):9582-9587. (2012)

Dang LC, O’Neil JP, Jagust WJ.

Striatal dopamine influences the default mode network to affect shifting between object features

Journal of Cognitive Neuroscience, Sep;24(9):1960-70 2012

Dang LC, Donde A, Madison C, O’Neil JP, Jagust WJ

Genetic effects on behavior are mediated by neurotransmitters and large-scale neural networks

Neuroimage, Nov 8;66C:203-214

Linh C Dang, James P O’Neil, and William J Jagust

Relative contributions of biomarkers in Alzheimer’s disease

Annals of Epidemiology 22:868-875, 2012

Haight TJ, Jagust WJ.

Apolipoprotein E, not fibrillar b-amyloid, reduces cerebral glucose metabolism in normal aging.

Journal of Neuroscience, 32:18227-18233, 2012.

Jagust WJ, Landau SM

Lifetime cognitive engagement is associated with low beta-amyloid deposition

Archives of Neurology, epub Jan 23, 2012

Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O’Neil JP. Wilson RS. Jagust WJ

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

Annals of Neurology 72:578-586, 2012

Landau SM, Mintun MA, Joshi AD, Koeppe RA, Petersen RC, Aisen PS, Weiner MW, Jagust WJ.

Amyloid-β Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods.

Journal of Nuclear Medicine Jan;54(1):70-7 2012

Landau SM, Breault C, Joshi AD, Pontecorvo M, Mathis CA, Jagust WJ, Mintun MA; for the Alzheimer’s Disease Neuroimaging Initiative.

Predicting missing biomarker data in a longitudinal study of Alzheimer disease

Neurology 78:1376-1382, 2012.

Lo RY, Jagust WJ.

Vascular burden and Alzheimer pathological progression.

Neurology, Sep 25;79(13):1349-55 2012

Lo RY, Jagust WJ.

Alcohol consumption induces endogenous opiod release in the human orbitofrontal cortex and nucleus accumbens

Science Translational Medicine, 11:116ra6, 2012

Mitchell JM, O’Neil JP, Janabi M, Marks SM, Jagust WJ, Fields HL

Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant

Neuroimage, 59:1152-1160, 2012

Mormino EC, Brandel MG, Madison CM, Rabinovici GD, Marks W, Baker SL, Jagust WJ

Effects of age and β-amyloid on cognitive changes in normal elderly people

Neurobiology of Aging 2012

Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust

Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly

Human Brain Mapping, epub Sep 11, 2012

Oh H, Habeck C, Madison C, Jagust W

Human Brain Mapping Link

Arch Neurol. 2012 Feb;69(2):223-9.

Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ.

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