18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.

Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD.

Alzheimers Res Ther. 2019 Jan 31;11(1):13. doi: 10.1186/s13195-019-0470-7.PMID: 30704514 [PubMed - in process]

“Alzheimer’s disease” is neither “Alzheimer’s clinical syndrome” nor “dementia”.

Jagust W, Jack CR Jr, Bennett DA, Blennow K, Haeberlein SB, Holtzman DM, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Sperling R.

Alzheimers Dement. 2019 Jan;15(1):153-157. doi: 10.1016/j.jalz.2018.11.002. No abstract available. PMID: 30642435 [PubMed - in process]

Longitudinal tau accumulation and atrophy in aging and Alzheimer's disease.

Harrison TM, La Joie R, Maass A, Baker SL, Swinnerton K, Fenton L, Mellinger TJ, Edwards L, Pham J, Miller BL, Rabinovici GD, Jagust WJ.

Ann Neurol. 2018 Dec 31. doi: 10.1002/ana.25406. [Epub ahead of print]PMID: 30597624

Age-related variability in decision-making: Insights from neurochemistry.

Berry AS, Jagust WJ, Hsu M.

Cogn Affect Behav Neurosci. 2018 Dec 10. doi: 10.3758/s13415-018-00678-9. [Epub ahead of print]PMID: 30536205

Biomarkers for tau pathology.

Schöll M, Maass A, Mattsson N, Ashton NJ, Blennow K, Zetterberg H, Jagust W.

Mol Cell Neurosci. 2018 Dec 7. pii: S1044-7431(18)30233-1. doi: 10.1016/j.mcn.2018.12.001. [Epub ahead of print] Review.PMID: 30529601

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.

Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C Jr, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe VJ, Masters CL, Mathis CA, McLean CL, Miller BL, Mungas D, O'Neil JP, Olichney JM, Parisi JE, Petersen RC, Rosen HJ, Rowe CC, Spina S, Vemuri P, Villemagne VL, Murray ME, Rabinovici GD.

Alzheimers Dement. 2018 Oct 19. pii: S1552-5260(18)33523-4. doi: 10.1016/j.jalz.2018.09.001. [Epub ahead of print]PMID: 30347188

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.

Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2018 Oct 12. pii: S1552-5260(18)33514-3. doi: 10.1016/j.jalz.2018.08.005. [Epub ahead of print] Review.PMID: 30321505

Imaging the evolution and pathophysiology of Alzheimer disease.

Jagust W.

Nat Rev Neurosci. 2018 Sep 28. doi: 10.1038/s41583-018-0067-3. [Epub ahead of print] Review.

Scan-time Corrections for 80-100 Minute Standardized Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging.

He M, Baker SL, Shah VD, Lockhart SN, Jagust WJ.

IEEE Trans Med Imaging. 2018 Sep 17. doi: 10.1109/TMI.2018.2870441. [Epub ahead of print]

Spatially Adaptive Varying Correlation Analysis for Multimodal Neuroimaging Data.

Li L, Kang J, Lockhart SN, Adams J, Jagust WJ.

IEEE Trans Med Imaging. 2018 Jul 18. doi: 10.1109/TMI.2018.2857221. [Epub ahead of print]

A New Tool for Clinical Neuroscience-Synaptic Imaging.

Mormino EC, Jagust WJ.

JAMA Neurol. 2018 Jul 16. doi: 10.1001/jamaneurol.2018.1643. [Epub ahead of print] 

Assessment of Extent and Role of Tau in Subcortical Vascular Cognitive Impairment Using 18F-AV1451 Positron Emission Tomography Imaging.

Kim HJ, Park S, Cho H, Jang YK, San Lee J, Jang H, Kim Y, Kim KW, Ryu YH, Choi JY, Moon SH, Weiner MW, Jagust WJ, Rabinovici GD, DeCarli C, Lyoo CH, Na DL, Seo SW.

JAMA Neurol. 2018 May 14. doi: 10.1001/jamaneurol.2018.0975. [Epub ahead of print]

The Influence of Dopamine on Cognitive Flexibility Is Mediated by Functional Connectivity in Young but Not Older Adults.

Berry AS, Shah VD, Jagust WJ.

J Cogn Neurosci. 2018 May 23:1-15. doi: 10.1162/jocn_a_01286. [Epub ahead of print]

Brain properties predict proximity to symptom onset in sporadic Alzheimer's disease.

Vogel JW, Vachon-Presseau E, Pichet Binette A, Tam A, Orban P, La Joie R, Savard M, Picard C, Poirier J, Bellec P, Breitner JCS, Villeneuve S; Alzheimer’s Disease Neuroimaging Initiative and the PREVENT-AD Research Group.

Brain. 2018 Apr 23. doi: 10.1093/brain/awy093. [Epub ahead of print]

Subthreshold amyloid predicts tau deposition in aging.

Leal SL, Lockhart SN, Maass A, Bell RK, Jagust WJ.

J Neurosci. 2018 Apr 23. pii: 0485-18. doi: 10.1523/JNEUROSCI.0485-18.2018. [Epub ahead of print]

Brain morphology, cognition, and β-amyloid in older adults with superior memory performance.

Harrison TM, Maass A, Baker SL, Jagust WJ.

Neurobiol Aging. 2018 Mar 27;67:162-170. doi: 10.1016/j.neurobiolaging.2018.03.024. [Epub ahead of print]

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.

Jack CR Jr., Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors.

Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018.

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Mattsson N, Groot C, Jansen WJ, Landau S, Villemagne V, Et al.

Alzheimers Dement. 2018 Mar 27. pii: S1552-5260(18)30063-3. doi: 10.1016/j.jalz.2018.02.009. [Epub ahead of print]

Memory decline accompanies subthreshold amyloid accumulation

Landau SM, Horng A, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2018 Mar 23. pii: 10.1212/WNL.0000000000005354. doi: 10.1212/WNL.0000000000005354. [Epub ahead of print]

Metabolic brain networks in aging and preclinical Alzheimer's disease

Arnemann KL, Stöber F, Narayan S, Rabinovici GD, Jagust WJ.

Neuroimage Clin. 2017 Dec 28;17:987-999. doi: 10.1016/j.nicl.2017.12.037. eCollection 2018.

Following the pathway to Alzheimer's disease

Jagust W

Nat Neurosci. 2018 Feb 23. doi: 10.1038/s41593-018-0085-5. [Epub ahead of print]

Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.

Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML.

JAMA Neurol. 2018 Jan 8. doi: 10.1001/jamaneurol.2017.4309. [Epub ahead of print]

Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting.

Helfrich RF, Mander BA, Jagust WJ, Knight RT, Walker MP.

Neuron. 2018 Jan 3;97(1):221-230.e4. doi: 10.1016/j.neuron.2017.11.020. Epub 2017 Dec 14.

Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample.

La Joie R, Bejanin A, Fagan AM, Ayakta N, Baker SL, Bourakova V, Boxer AL, Cha J, Karydas A, Jerome G, Maass A, Mensing A, Miller ZA, O'Neil JP, Pham J, Rosen HJ, Tsai R, Visani AV, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2017 Dec 27. pii: 10.1212/WNL.0000000000004860. doi: 10.1212/WNL.0000000000004860. [Epub ahead of print]

Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease.

Winer JR, Maass A, Pressman P, Stiver J, Schonhaut DR, Baker SL, Kramer J, Rabinovici GD, Jagust WJ.

JAMA Neurol. 2017 Dec 11. doi: 10.1001/jamaneurol.2017.3713. [Epub ahead of print]

Entorhinal tau pathology, episodic memory decline and neurodegeneration in aging.

Maass A, Lockhart SN, Harrison TM, Bell RK, Mellinger T, Swinnerton K, Baker SL, Rabinovici GD, Jagust WJ.

J Neurosci. 2017 Nov 30. pii: 2028-17. doi: 10.1523/JNEUROSCI.2028-17.2017. [Epub ahead of print]

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.

Neuroimage Clin. 2017 Sep 25;17:452-464. doi: 10.1016/j.nicl.2017.09.016. eCollection 2018

Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD.

Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia.

Eur J Nucl Med Mol Imaging. 2017 Nov 16. doi: 10.1007/s00259-017-3876-0. [Epub ahead of print]

Jang YK, Lyoo CH, Park S, Oh SJ, Cho H, Oh M, Ryu YH, Choi JY, Rabinovici GD, Kim HJ, Moon SH, Jang H, Lee JS, Jagust WJ, Na DL, Kim JS, Seo SW.

Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data.

Data Brief. 2017 Oct 16;15:648-657. doi: 10.1016/j.dib.2017.10.024. eCollection 2017 Dec.

Baker SL, Maass A, Jagust WJ.

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity.

Nat Commun. 2017 Oct 31;8(1):1214. doi: 10.1038/s41467-017-01150-x.

Palmqvist S, Schöll M, Strandberg O, Mattsson N, Stomrud E, Zetterberg H, Blennow K, Landau S, Jagust W, Hansson O.

White matter structure in older adults moderates the benefit of sleep spindles on motor memory consolidation.

J Neurosci. 2017 Oct 30. pii: 3033-16. doi: 10.1523/JNEUROSCI.3033-16.2017. [Epub ahead of print]

Mander BA, Zhu AH, Lindquist JR, Villeneuve S, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust W, Walker MP.

Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.

Brain. 2017 Oct 7. doi: 10.1093/brain/awx243. [Epub ahead of print]

Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, Ayakta N, Cantwell A, Janabi M, Lauriola M, O'Neil JP, Gorno-Tempini ML, Miller ZA, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD.

Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but not Dopamine Release.

Neuropsychopharmacology. 2017 Aug 17. doi: 10.1038/npp.2017.180. [Epub ahead of print]

Berry AS, Shah VD, Furman DJ, White RL, Baker SL, O'Neil JP, Janabi M, D'Esposito M, Jagust WJ

Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.

Biol Psychiatry. 2017 Jun 16. pii: S0006-3223(17)31672-4.   doi: 10.1016/j.biopsych.2017.06.010. [Epub ahead of print]

van Holst RJ, Sescousse G, Janssen LK, Janssen M, Berry AS, Jagust WJ, Cools R.

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's Disease.

Neuroimage. 2017 Jun 3. pii: S1053-8119(17)30458-5. doi: 10.1016/j.neuroimage.2017.05.058. [Epub ahead of print]

Maass A, Landau S, Baker SL, Horng A, Lockhart SN, Joie R, Rabinovici GD, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative.

Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.

JAMA Neurol. 2017 Mar 20. doi: 10.1001/jamaneurol.2016.5349. [Epub ahead of print]

Schreiber S, Schreiber F, Lockhart SN, Horng A, Bejanin A, Landau SM, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative

Tau and Beta-amyloid are associated with medial temporal lobe structure, function and memory encoding in normal aging.

J Neurosci. 2017 Feb 17. pii: 3769-16. doi: 10.1523/JNEUROSCI.3769-16.2017. [Epub ahead of print] PMID: 28213439

Marks SM, Lockhart SN, Baker SL, Jagust W

Elevated 18 F-AV-1451 PET tracer uptake detected in incidental imaging findings.

Neurology. 2017 Feb 10. pii: 10.1212/WNL.0000000000003724. doi: 10.1212/WNL.0000000000003724. [Epub ahead of print]

Lockhart SN, Ayakta N, Winer JR, La Joie R, Rabinovici GD, Jagust WJ.

Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline.

Elife. 2017 Feb 8;6. pii: e22978. doi: 10.7554/eLife.22978. [Epub ahead of print]

Leal SL, Landau SM, Bell RK, Jagust WJ.

Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.

Neurology. 2017 Jan 27. pii: 10.1212/WNL.0000000000003636. doi: 10.1212/WNL.0000000000003636. [Epub ahead of print]

Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD.

Aging affects dopaminergic neural mechanisms of cognitive flexibility.

J Neurosci. 2016 Nov 2. pii: 0626-16. [Epub ahead of print]

Berry AS, Shah VD, Baker SL, Vogel JW, O’Neil JP, Janabi M, Schwimmer HD, Marks SM, Jagust WJ.

Reference tissue-based kinetic evaluation of 18F-AV-1451 in aging and dementia.

J Nucl Med. 2016 Sep 1. pii: jnumed.116.175273. [Epub ahead of print]

Baker SL, Lockhart SN, Price JC, He M, Huesman RH, Schonhaut D, Faria J, Rabinovici G, Jagust WJ.

Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer’s disease.

Hum Brain Mapp. 2016 Jul 13. doi: 10.1002/hbm.23305. [Epub ahead of print]

Ballarini T, Iaccarino L, Magnani G, Ayakta N, Miller BL, Jagust WJ, Gorno-Tempini ML, D Rabinovici G, Perani D.

Early life sets the stage for aging.

Proc Natl Acad Sci U S A. 2016 Jul 19. pii: 201609720. [Epub ahead of print]

Jagust WJ.

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer’s Disease Patients Measured Using [18F] THK-5351.

PLoS One. 2016 Jun 29;11(6):e0158460. doi: 10.1371/journal.pone.0158460. eCollection 2016.

Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ.

Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer’s disease.

Brain. 2016 Jun 29. pii: aww159. [Epub ahead of print]

Chételat G, Ossenkoppele R, Villemagne VL, Perrotin A, Landeau B, Mézenge F, Jagust WJ, Dore V, Miller BL, Egret S, Seeley WW, van der Flier WM, La Joie R, Ames D, van Berckel BN, Scheltens P, Barkhof F, Rowe CC, Masters CL, de La Sayette V, Bouwman F, Rabinovici GD.

Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer’s Disease?

Trends Neurosci. 2016 Jun 17. pii: S0166-2236(16)30037-6. doi: 10.1016/j.tins.2016.05.002. [Epub ahead of print] Review.

Mander BA, Winer J, Jagust WJ, Walker MP.

Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology.

Neurology. 2016 Apr 15. pii: 10.1212/WNL.0000000000002683. [Epub ahead of print]

Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative.

Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI.

Neurology. 2016 Mar 11. pii: 10.1212/WNL.0000000000002576. [Epub ahead of print]

Landau SM, Horng A, Fero A, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease.

Brain. 2016 Mar 8. pii: aww027. [Epub ahead of print]

Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O’Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD

PET Imaging of Tau Deposition in the Aging Human Brain.

Neuron. 2016 Mar 2; 89, 971–982; doi: 10.1016/j.neuron.2016.01.028

Michael Schöll, Samuel N Lockhart, Daniel R Schonhaut, Henry D Schwimmer, Gil D Rabinovici, William J Jagust Correspondence, Michael Schö Ll, James P O ‘neil, Mustafa Janabi, Rik Ossenkoppele, Suzanne L Baker, Jacob W Vogel, Jamie Faria, William J Jagust

Braak ROIs: Supplimental info

Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment.

J Alzheimers Dis. 2016 Jan 19;50(4):1125-35. doi: 10.3233/JAD-150841.

Jung NY, Han CE, Kim HJ, Yoo SW, Kim HJ, Kim EJ, Na DL, Lockhart SN, Jagust WJ, Seong JK, Seo SW

Modulation of Impulsivity and Reward Sensitivity in Intertemporal Choice by Striatal and Midbrain Dopamine Synthesis in Healthy Adults.

J Neurophysiol. 2015 Dec 16:jn.00261.2015. doi: 10.1152/jn.00261.2015.

Smith CT, Wallace DL, Dang LC, Aarts E, Jagust WJ, D’Esposito M, Boettiger CA

Is amyloid-β harmful to the brain? Insights from human imaging studies.

Brain. 2015 Nov 27. pii: awv326.

Jagust, WJ

Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-β-Positive Subjects in the Alzheimer’s Disease Continuum.

Neurodegener Dis. 2016;16(1-2):87-94. doi: 10.1159/000439257. Epub 2015 Nov 12.

Tosun D, Schuff N, Jagust W, Weiner MW; Alzheimer’’s Disease Neuroimaging Initiative.

Comparison of Visual and Quantitative Florbetapir F 18 Positron Emission Tomography Analysis in Predicting Mild Cognitive Impairment Outcomes.

JAMA Neurol. 2015 Oct 1;72(10):1183-90. doi: 10.1001/jamaneurol.2015.1633.

Schreiber S, Landau SM, Fero A, Schreiber F, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Regional brain hypometabolism is unrelated to regional amyloid plaque burden.

Brain. 2015 Dec;138(Pt 12):3734-46. doi: 10.1093/brain/awv278. Epub 2015 Sep 29.

Altmann A, Ng B, Landau SM, Jagust WJ, Greicius MD; Alzheimer’s Disease Neuroimaging Initiative.

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer’s disease.

Hum Brain Mapp. 2015 Nov;36(11):4421-37. doi: 10.1002/hbm.22927. Epub 2015 Aug 11.

Ossenkoppele R, Cohn-Sheehy BI, La Joie R, Vogel JW, Möller C, Lehmann M, van Berckel BN, Seeley WW, Pijnenburg YA, Gorno-Tempini ML,Kramer JH, Barkhof F, Rosen HJ, van der Flier WM, Jagust WJ, Miller BL, Scheltens P, Rabinovici GD

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP.

Brain. 2015 Oct;138(Pt 10):3076-88. doi: 10.1093/brain/awv231. Epub 2015 Aug 11.

Ramanan VK, Risacher SL, Nho K, Kim S, Shen L, McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S, Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, Jagust WJ, Weiner MW, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer’s disease variants.

Neurobiol Aging. 2015 Oct;36(10):2678-86. doi: 10.1016/j.neurobiolaging.2015.06.029. Epub 2015 Jul 16.

Lehmann M, Madison C, Ghosh PM, Miller ZA, Greicius MD, Kramer JH, Coppola G, Miller BL, Jagust WJ, Gorno-Tempini ML, Seeley WW, Rabinovici GD

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.

Neurol Genet. 2015 Oct 15;1(3):e22. doi: 10.1212/NXG.0000000000000022. eCollection 2015 Oct.

Lazaris A, Hwang KS, Goukasian N, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin AJ, Shaw LM, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG; Alzheimer’s Disease Neuroimaging Initiative.

The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features.

Brain. 2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2.

Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, Joie RL, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD

The Alzheimer’s Disease Neuroimaging Initiative 2 PET Core: 2015.

The Alzheimer’s Disease Neuroimaging Initiative 2 PET Core: 2015

Jagust WJ, Landau SM, Koeppe RA, Reiman EM, Chen K, Mathis CA, Price JC, Foster NL, Wang AY

Impact of the Alzheimer’s Disease Neuroimaging Initiative, 2004 to 2014.

Alzheimers Dement. 2015 Jul;11(7):865-84. doi: 10.1016/j.jalz.2015.04.005. Review.

Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Donohue MC, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw L, Thompson PM, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative.

Amyloid in dementia associated with familial FTLD: not an innocent bystander.

Neurocase. 2016 Feb;22(1):76-83. doi: 10.1080/13554794.2015.1046458. Epub 2015 Jun 4.

Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ

2014 Update of the Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception.

Alzheimers Dement. 2015 Jun;11(6):e1-120. doi: 10.1016/j.jalz.2014.11.001.

Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Green RC, Harvey D, Jack CR, Jagust W, Luthman J, Morris JC, Petersen RC, Saykin AJ, Shaw L, Shen L, Schwarz A, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative.

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4035. [Epub ahead of print]

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.

JAMA. 2015 May 19;313(19):1939-49. doi: 10.1001/jama.2015.4669.

Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BN, Scheltens P, Visser PJ; Amyloid PET Study Group, Verfaillie SC, Zwan MD, Adriaanse SM, Lammertsma AA, Barkhof F, Jagust WJ, Miller BL, Rosen HJ, Landau SM, Villemagne VL, Rowe CC, Lee DY, Na DL, Seo SW, Sarazin M, Roe CM, Sabri O, Barthel H, Koglin N, Hodges J, Leyton CE, Vandenberghe R, van Laere K, Drzezga A, Forster S, Grimmer T, Sánchez-Juan P, Carril JM, Mok V, Camus V, Klunk WE, Cohen AD, Meyer PT, Hellwig S, Newberg A, Frederiksen KS, Fleisher AS, Mintun MA, Wolk DA, Nordberg A, Rinne JO, Chételat G, Lleo A, Blesa R, Fortea J, Madsen K, Rodrigue KM, Brooks DJ

Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods.

Appetite. 2015 May 8;92:74-80. doi: 10.1016/j.appet.2015.05.004. [Epub ahead of print]

Wallace DL, Aarts E, d’Oleire Uquillas F, Dang LC, Greer SM, Jagust WJ, D’Esposito M

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

Brain. 2015 Jul;138(Pt 7):2020-33. doi: 10.1093/brain/awv112. Epub 2015 May 6.

Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen H, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin L, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust WJ

Clustering-initiated factor analysis application for tissue classification in dynamic brain positron emission tomography

J Cereb Blood Flow Metab. 2015 Apr 22. doi: 10.1038/jcbfm.2015.69. [Epub ahead of print]

Boutchko R, Mitra D, Baker SL, Jagust WJ, Gullberg GT

Measurement of longitudinal Aβ change with 18F florbetapir PET and standard uptake value ratios

J Nucl Med. 2015 Apr;56(4):567-74

Landau SM, Fero A, Baker SL, Koeppe RA, Mintun M, Chen K, Reiman E, Jagust W

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4035. [Epub ahead of print]

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

Dopamine and the cognitive downside of a promised bonus

Psychol Sci. 2014 Apr;25(4):1003-9

Aarts E, Wallace DL, Dang LC, Jagust WJ, Cools R, D’Esposito M

Neural compensation in older people with brain amyloid-β deposition

Nat Neurosci. 2014 Oct;17(10):1316-8

Elman JA, Oh H, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ

Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability

Cereb Cortex. 2014 Nov 7. pii: bhu259. [Epub ahead of print]

Elman JA, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ

Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers

Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1398-407

Landau SM, Thomas BA, Thurfjell L, Schmidt M, Margolin R, Mintun M, Pontecorvo M, Baker SL, Jagust WJ

Associations between serum cholesterol levels and cerebral amyloidosis

JAMA Neurology 71:195-200, 2014

Reed B, Villeneuve S, Mack W, DeCarli C, Chui HC, Jagust WJ

Cortical thickness mediates the effect of b-amyloid on episodic memory

Neurology 82:761-7, 2014

Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N, Mack W, Mungas D, Chui HC, DeCarli C, Weiner MW, Jagust WJ

Vascular risk and Ab interact to reduct cortical thickness in AD vulnerable brain regions

Neurology 83: 40-47, 2014

Villeneuve S, Reed BR, Madison CM, Wirth M, Marchant NL, Kriger S, Mack WJ, Sanossian N, DeCarli C, Chui HC, Weiner MW, Jagust WJ

Dorsal striatal dopamine, food preference and health perception in humans

PloS One May 7 9(5):e96319, 2014

Wallace DL, Aarts E, Dang LC, Greer SM, Jagust WJ, D’Esposito M

Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal adults

Neurobiology of Aging 35:1873-1882, 2014

Wirth M, Haase CM, Villeneuve S, Vogel J, Jagust WJ

Gene-Environment interactions: Lifetime cognitive activity, ApoE genotype and beta-amyloid burden

Journal of Neuroscience 34: 8612-8617, 2014

Wirth M, Villeneuve S, La Joie R, Marks SM, Jagust WJ

Vulnerable neural systems and the borderland of brain aging and neurodegeneration

Neuron 77:219-234, 2013

Jagust, W.

Comparing Positron Emission Tomography Imaging and Cerebrospinal Fluid Measurements of b-Amyloid

Ann Neurol. 2013 Dec;74(6):826-36

Landau SM, Lu M, Joshi AD, Pontecorvo M, Mintun MA, Trojanowski JQ, Shaw LM, Jagust WJ for the Alzheimer’s Disease Neuroimaging Initiative

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease

Brain. 2013 Mar;136(Pt 3):844-58

Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

Journal of Neurology, Neurosurgery and Psychiatry Aug 21, 2013

Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O’Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD

Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer’s disease.

Proceedings of the National Academy of Sciences USA, 110:11606-11611, 2013

Lehmann M, Madison CM, Ghosh PM, Seeley WW, Mormino E, Greicius MD, Gorno-Tempini ML, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD

Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging

Nature Neuroscience 16:357-364, 2013.

Mander BA, Rao V, Lu B, Saletin JM, Lindquist JR, Ancoli-Israel S, Jagust W, Walker MP.

Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults

Cerebral Cortex July 30, 2013

Mander BA, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

The aging brain and cognition: Contribution of vascular injury and Ab to mild cognitive dysfunction.

JAMA Neurology Apri 1, 2013

Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ

Association of gray matter atrophy with age, b-amyloid, and cognition in aging

Cerebral Cortex Feb 6 2013

Oh H, Madison C, Villeneuve S, Markley C, Jagust WJ

Frontotemporal Network Connectivity during Memory Encoding Is Increased with Aging and Disrupted by Beta-Amyloid.

J Neurosci. 2013 Nov 20

Oh H, Jagust WJ.

Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people

JAMA Neurology 70:1512-1519, 2013

Wirth M, Villeneuve S, Haase CM, Madison CM, Oh H, Landau SM, Rabinovici GD, Jagust WJ

Dopamine supports coupling of attention-related networks

Journal of Neuroscience, 32(28):9582-9587. (2012)

Dang LC, O’Neil JP, Jagust WJ.

Striatal dopamine influences the default mode network to affect shifting between object features

Journal of Cognitive Neuroscience, Sep;24(9):1960-70 2012

Dang LC, Donde A, Madison C, O’Neil JP, Jagust WJ

Genetic effects on behavior are mediated by neurotransmitters and large-scale neural networks

Neuroimage, Nov 8;66C:203-214

Linh C Dang, James P O’Neil, and William J Jagust

Relative contributions of biomarkers in Alzheimer’s disease

Annals of Epidemiology 22:868-875, 2012

Haight TJ, Jagust WJ.

Apolipoprotein E, not fibrillar b-amyloid, reduces cerebral glucose metabolism in normal aging.

Journal of Neuroscience, 32:18227-18233, 2012.

Jagust WJ, Landau SM

Lifetime cognitive engagement is associated with low beta-amyloid deposition

Archives of Neurology, epub Jan 23, 2012

Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O’Neil JP. Wilson RS. Jagust WJ

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

Annals of Neurology 72:578-586, 2012

Landau SM, Mintun MA, Joshi AD, Koeppe RA, Petersen RC, Aisen PS, Weiner MW, Jagust WJ.

Amyloid-β Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods.

Journal of Nuclear Medicine Jan;54(1):70-7 2012

Landau SM, Breault C, Joshi AD, Pontecorvo M, Mathis CA, Jagust WJ, Mintun MA; for the Alzheimer’s Disease Neuroimaging Initiative.

Predicting missing biomarker data in a longitudinal study of Alzheimer disease

Neurology 78:1376-1382, 2012.

Lo RY, Jagust WJ.

Vascular burden and Alzheimer pathological progression.

Neurology, Sep 25;79(13):1349-55 2012

Lo RY, Jagust WJ.

Alcohol consumption induces endogenous opiod release in the human orbitofrontal cortex and nucleus accumbens

Science Translational Medicine, 11:116ra6, 2012

Mitchell JM, O’Neil JP, Janabi M, Marks SM, Jagust WJ, Fields HL

Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant

Neuroimage, 59:1152-1160, 2012

Mormino EC, Brandel MG, Madison CM, Rabinovici GD, Marks W, Baker SL, Jagust WJ

Effects of age and β-amyloid on cognitive changes in normal elderly people

Neurobiology of Aging 2012

Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust

Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly

Human Brain Mapping, epub Sep 11, 2012

Oh H, Habeck C, Madison C, Jagust W

Human Brain Mapping Link

Arch Neurol. 2012 Feb;69(2):223-9.

Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ.

Supplementary On-line Content