Publications

Supplemental Data

Publication Timeline

2016

[Ballarini2016]

Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer’s disease.

Hum Brain Mapp. 2016 Jul 13. doi: 10.1002/hbm.23305. [Epub ahead of print]

Ballarini T, Iaccarino L, Magnani G, Ayakta N, Miller BL, Jagust WJ, Gorno-Tempini ML, D Rabinovici G, Perani D.

pubmed

[Jagust2016]

Early life sets the stage for aging.

Proc Natl Acad Sci U S A. 2016 Jul 19. pii: 201609720. [Epub ahead of print]

Jagust WJ.

pubmed

[Lockhart2016]

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer’s Disease Patients Measured Using [18F] THK-5351.

PLoS One. 2016 Jun 29;11(6):e0158460. doi: 10.1371/journal.pone.0158460. eCollection 2016.

Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ.

pubmed

[Chételat2016]

Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer’s disease.

Brain. 2016 Jun 29. pii: aww159. [Epub ahead of print]

Chételat G, Ossenkoppele R, Villemagne VL, Perrotin A, Landeau B, Mézenge F, Jagust WJ, Dore V, Miller BL, Egret S, Seeley WW, van der Flier WM, La Joie R, Ames D, van Berckel BN, Scheltens P, Barkhof F, Rowe CC, Masters CL, de La Sayette V, Bouwman F, Rabinovici GD.

pubmed

[Mander2016]

Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer’s Disease?

Trends Neurosci. 2016 Jun 17. pii: S0166-2236(16)30037-6. doi: 10.1016/j.tins.2016.05.002. [Epub ahead of print] Review.

Mander BA, Winer J, Jagust WJ, Walker MP.

pubmed

[Insel2016]

Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology.

Neurology. 2016 Apr 15. pii: 10.1212/WNL.0000000000002683. [Epub ahead of print]

Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Landau2016]

Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI.

Neurology. 2016 Mar 11. pii: 10.1212/WNL.0000000000002576. [Epub ahead of print]

Landau SM, Horng A, Fero A, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Ossenkoppele2016]

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease.

Brain. 2016 Mar 8. pii: aww027. [Epub ahead of print]

Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O’Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD

pubmed

[Schöll2016]

PET Imaging of Tau Deposition in the Aging Human Brain

Neuron. 2016 Mar 2; 89, 971–982; doi: 10.1016/j.neuron.2016.01.028

Michael Schöll, Samuel N Lockhart, Daniel R Schonhaut, Henry D Schwimmer, Gil D Rabinovici, William J Jagust Correspondence, Michael Schö Ll, James P O ‘neil, Mustafa Janabi, Rik Ossenkoppele, Suzanne L Baker, Jacob W Vogel, Jamie Faria, William J Jagust

[Jung2016]

Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment.

J Alzheimers Dis. 2016 Jan 19;50(4):1125-35. doi: 10.3233/JAD-150841.

Jung NY, Han CE, Kim HJ, Yoo SW, Kim HJ, Kim EJ, Na DL, Lockhart SN, Jagust WJ, Seong JK, Seo SW

pubmed

2015

[Smith2015]

Modulation of Impulsivity and Reward Sensitivity in Intertemporal Choice by Striatal and Midbrain Dopamine Synthesis in Healthy Adults.

J Neurophysiol. 2015 Dec 16:jn.00261.2015. doi: 10.1152/jn.00261.2015.

Smith CT, Wallace DL, Dang LC, Aarts E, Jagust WJ, D’Esposito M, Boettiger CA

pubmed

[Jagust2015]

Is amyloid-β harmful to the brain? Insights from human imaging studies.

Brain. 2015 Nov 27. pii: awv326.

pubmed

[Tosun2015]

Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-β-Positive Subjects in the Alzheimer’s Disease Continuum.

Neurodegener Dis. 2016;16(1-2):87-94. doi: 10.1159/000439257. Epub 2015 Nov 12.

Tosun D, Schuff N, Jagust W, Weiner MW; Alzheimer’’s Disease Neuroimaging Initiative.

pubmed

[Schreiber2015]

Comparison of Visual and Quantitative Florbetapir F 18 Positron Emission Tomography Analysis in Predicting Mild Cognitive Impairment Outcomes.

JAMA Neurol. 2015 Oct 1;72(10):1183-90. doi: 10.1001/jamaneurol.2015.1633.

Schreiber S, Landau SM, Fero A, Schreiber F, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Altmann2015]

Regional brain hypometabolism is unrelated to regional amyloid plaque burden.

Brain. 2015 Dec;138(Pt 12):3734-46. doi: 10.1093/brain/awv278. Epub 2015 Sep 29.

Altmann A, Ng B, Landau SM, Jagust WJ, Greicius MD; Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Ossenkoppele2015]

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer’s disease.

Hum Brain Mapp. 2015 Nov;36(11):4421-37. doi: 10.1002/hbm.22927. Epub 2015 Aug 11.

Ossenkoppele R, Cohn-Sheehy BI, La Joie R, Vogel JW, Möller C, Lehmann M, van Berckel BN, Seeley WW, Pijnenburg YA, Gorno-Tempini ML,Kramer JH, Barkhof F, Rosen HJ, van der Flier WM, Jagust WJ, Miller BL, Scheltens P, Rabinovici GD

pubmed

[Ramanan2015]

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP.

Brain. 2015 Oct;138(Pt 10):3076-88. doi: 10.1093/brain/awv231. Epub 2015 Aug 11.

Ramanan VK, Risacher SL, Nho K, Kim S, Shen L, McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S, Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, Jagust WJ, Weiner MW, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

pubmed

[Lehmann2015]

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer’s disease variants.

Neurobiol Aging. 2015 Oct;36(10):2678-86. doi: 10.1016/j.neurobiolaging.2015.06.029. Epub 2015 Jul 16.

Lehmann M, Madison C, Ghosh PM, Miller ZA, Greicius MD, Kramer JH, Coppola G, Miller BL, Jagust WJ, Gorno-Tempini ML, Seeley WW, Rabinovici GD

pubmed

[Lazaris2016]

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.

Neurol Genet. 2015 Oct 15;1(3):e22. doi: 10.1212/NXG.0000000000000022. eCollection 2015 Oct.

Lazaris A, Hwang KS, Goukasian N, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin AJ, Shaw LM, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG; Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Ossenkoppele2015]

The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features.

Brain. 2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2.

Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, Joie RL, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD

pubmed

[Jagust2015]

The Alzheimer’s Disease Neuroimaging Initiative 2 PET Core: 2015.

The Alzheimer’s Disease Neuroimaging Initiative 2 PET Core: 2015

Jagust WJ, Landau SM, Koeppe RA, Reiman EM, Chen K, Mathis CA, Price JC, Foster NL, Wang AY

pubmed

[Weiner2015]

Impact of the Alzheimer’s Disease Neuroimaging Initiative, 2004 to 2014.

Alzheimers Dement. 2015 Jul;11(7):865-84. doi: 10.1016/j.jalz.2015.04.005. Review.

Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Donohue MC, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw L, Thompson PM, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Naasan2015]

Amyloid in dementia associated with familial FTLD: not an innocent bystander.

Neurocase. 2016 Feb;22(1):76-83. doi: 10.1080/13554794.2015.1046458. Epub 2015 Jun 4.

Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ

pubmed

[Weiner2015]

2014 Update of the Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception.

Alzheimers Dement. 2015 Jun;11(6):e1-120. doi: 10.1016/j.jalz.2014.11.001.

Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Green RC, Harvey D, Jack CR, Jagust W, Luthman J, Morris JC, Petersen RC, Saykin AJ, Shaw L, Shen L, Schwarz A, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Mander2015]

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4035. [Epub ahead of print]

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

pubmed

[Ossenkoppele2015]

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.

JAMA. 2015 May 19;313(19):1939-49. doi: 10.1001/jama.2015.4669.

Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BN, Scheltens P, Visser PJ; Amyloid PET Study Group, Verfaillie SC, Zwan MD, Adriaanse SM, Lammertsma AA, Barkhof F, Jagust WJ, Miller BL, Rosen HJ, Landau SM, Villemagne VL, Rowe CC, Lee DY, Na DL, Seo SW, Sarazin M, Roe CM, Sabri O, Barthel H, Koglin N, Hodges J, Leyton CE, Vandenberghe R, van Laere K, Drzezga A, Forster S, Grimmer T, Sánchez-Juan P, Carril JM, Mok V, Camus V, Klunk WE, Cohen AD, Meyer PT, Hellwig S, Newberg A, Frederiksen KS, Fleisher AS, Mintun MA, Wolk DA, Nordberg A, Rinne JO, Chételat G, Lleo A, Blesa R, Fortea J, Madsen K, Rodrigue KM, Brooks DJ

pubmed

[Wallace2015]

Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods.

Appetite. 2015 May 8;92:74-80. doi: 10.1016/j.appet.2015.05.004. [Epub ahead of print]

Wallace DL, Aarts E, d’Oleire Uquillas F, Dang LC, Greer SM, Jagust WJ, D’Esposito M

pubmed

[Villeneuve2015]

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

Brain. 2015 Jul;138(Pt 7):2020-33. doi: 10.1093/brain/awv112. Epub 2015 May 6.

Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen H, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin L, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust WJ

pubmed

[Boutchko2015]

Clustering-initiated factor analysis application for tissue classification in dynamic brain positron emission tomography

J Cereb Blood Flow Metab. 2015 Apr 22. doi: 10.1038/jcbfm.2015.69. [Epub ahead of print]

Boutchko R, Mitra D, Baker SL, Jagust WJ, Gullberg GT

pubmed

[Landau2015]

Measurement of longitudinal Aβ change with 18F florbetapir PET and standard uptake value ratios

J Nucl Med. 2015 Apr;56(4):567-74

Landau SM, Fero A, Baker SL, Koeppe RA, Mintun M, Chen K, Reiman E, Jagust W

pubmed

[Mander2015]

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4035. [Epub ahead of print]

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

pubmed

[Ossenkoppele2015]

Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy.

Ann Neurol. 2015 Feb;77(2):338-42.

Ossenkoppele R, Schonhaut DR, Baker SL, O’Neil JP, Janabi M, Ghosh PM, Santos M, Miller ZA, Bettcher BM, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD

pubmed

[Villeneuve2015]

Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment.

J Prev Alzheimers Dis. 2015 Mar;2(1):64-70

Villeneuve S, Jagust WJ

pubmed

[Villeneuve2015b]

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

Brain. 2015 May 6. pii: awv112. [Epub ahead of print]

Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh P, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen HJ, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin L, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust WJ

pubmed

[Wallace2015]

Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods.

Appetite. 2015 May 8;92:74-80. doi: 10.1016/j.appet.2015.05.004. [Epub ahead of print]

Wallace DL, Aarts E, d’Oleire Uquillas F, Dang LC, Greer SM, Jagust WJ, D’Esposito M

pubmed

2014

[Aarts2014]

Dopamine and the cognitive downside of a promised bonus

Psychol Sci. 2014 Apr;25(4):1003-9

Aarts E, Wallace DL, Dang LC, Jagust WJ, Cools R, D’Esposito M

pubmed

[Elman2014]

Neural compensation in older people with brain amyloid-β deposition

Nat Neurosci. 2014 Oct;17(10):1316-8

Elman JA, Oh H, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ

pubmed

[Elman2014_2]

Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability

Cereb Cortex. 2014 Nov 7. pii: bhu259. [Epub ahead of print]

Elman JA, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ

pubmed

[Landau2014]

Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers

Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1398-407

Landau SM, Thomas BA, Thurfjell L, Schmidt M, Margolin R, Mintun M, Pontecorvo M, Baker SL, Jagust WJ

pubmed

[Reed2014]

Associations between serum cholesterol levels and cerebral amyloidosis

JAMA Neurology 71:195-200, 2014

Reed B, Villeneuve S, Mack W, DeCarli C, Chui HC, Jagust WJ

pubmed

[Villeneuve2014]

Cortical thickness mediates the effect of b-amyloid on episodic memory

Neurology 82:761-7, 2014

Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N, Mack W, Mungas D, Chui HC, DeCarli C, Weiner MW, Jagust WJ

pubmed

[Villeneuve2014_2]

Vascular risk and Ab interact to reduct cortical thickness in AD vulnerable brain regions

Neurology 83: 40-47, 2014

Villeneuve S, Reed BR, Madison CM, Wirth M, Marchant NL, Kriger S, Mack WJ, Sanossian N, DeCarli C, Chui HC, Weiner MW, Jagust WJ

pubmed

[Wallace2014]

Dorsal striatal dopamine, food preference and health perception in humans

PloS One May 7 9(5):e96319, 2014

Wallace DL, Aarts E, Dang LC, Greer SM, Jagust WJ, D’Esposito M

pubmed

[Wirth2014]

Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal adults

Neurobiology of Aging 35:1873-1882, 2014

Wirth M, Haase CM, Villeneuve S, Vogel J, Jagust WJ

pubmed

[Wirth2014_2]

Gene-Environment interactions: Lifetime cognitive activity, ApoE genotype and beta-amyloid burden

Journal of Neuroscience 34: 8612-8617, 2014

Wirth M, Villeneuve S, La Joie R, Marks SM, Jagust WJ

pubmed

2013

[Jagust2013]

Vulnerable neural systems and the borderland of brain aging and neurodegeneration

Neuron 77:219-234, 2013

Jagust W

pubmed

[Landau2013]

Comparing Positron Emission Tomography Imaging and Cerebrospinal Fluid Measurements of b-Amyloid

Ann Neurol. 2013 Dec;74(6):826-36

Landau SM, Lu M, Joshi AD, Pontecorvo M, Mintun MA, Trojanowski JQ, Shaw LM, Jagust WJ for the Alzheimer’s Disease Neuroimaging Initiative

pubmed

[Lehmann2013]

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease

Brain. 2013 Mar;136(Pt 3):844-58

Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

pubmed

[Lehmann2013_2]

Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

Journal of Neurology, Neurosurgery and Psychiatry Aug 21, 2013

Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O’Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD

pubmed

[Lehmann2013_3]

Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer’s disease.

Proceedings of the National Academy of Sciences USA, 110:11606-11611, 2013

Lehmann M, Madison CM, Ghosh PM, Seeley WW, Mormino E, Greicius MD, Gorno-Tempini ML, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD

pubmed

[Mander2013]

Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging

Nature Neuroscience 16:357-364, 2013.

Mander BA, Rao V, Lu B, Saletin JM, Lindquist JR, Ancoli-Israel S, Jagust W, Walker MP.

pubmed

[Mander2013_2]

Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults

Cerebral Cortex July 30, 2013

Mander BA, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP

pubmed

[Marchant2013]

The aging brain and cognition: Contribution of vascular injury and Ab to mild cognitive dysfunction.

JAMA Neurology Apri 1, 2013

Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ

pubmed

[Oh2013]

Association of gray matter atrophy with age, b-amyloid, and cognition in aging

Cerebral Cortex Feb 6 2013

Oh H, Madison C, Villeneuve S, Markley C, Jagust WJ

pubmed

[Oh2013_2]

Frontotemporal Network Connectivity during Memory Encoding Is Increased with Aging and Disrupted by Beta-Amyloid.

J Neurosci. 2013 Nov 20

Oh H, Jagust WJ.

pubmed

[Wirth2013]

Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people

JAMA Neurology 70:1512-1519, 2013

Wirth M, Villeneuve S, Haase CM, Madison CM, Oh H, Landau SM, Rabinovici GD, Jagust WJ

pubmed

2012

[Dang2012]

Dopamine supports coupling of attention-related networks

Journal of Neuroscience, 32(28):9582-9587. (2012)

Dang LC, O’Neil JP, Jagust WJ.

pubmed

[Dang2012_2]

Striatal dopamine influences the default mode network to affect shifting between object features

Journal of Cognitive Neuroscience, Sep;24(9):1960-70 2012

Dang LC, Donde A, Madison C, O’Neil JP, Jagust WJ.

pubmed

[Dang2012_3]

Genetic effects on behavior are mediated by neurotransmitters and large-scale neural networks

Neuroimage, Nov 8;66C:203-214

Linh C Dang, James P O’Neil, and William J Jagust

pubmed

[Haight2012]

Relative contributions of biomarkers in Alzheimer’s disease

Annals of Epidemiology 22:868-875, 2012

Haight TJ, Jagust WJ.

pubmed

[Jagust2012]

Apolipoprotein E, not fibrillar b-amyloid, reduces cerebral glucose metabolism in normal aging.

Journal of Neuroscience, 32:18227-18233, 2012.

Jagust WJ, Landau SM

pubmed

[Landau2012]

Lifetime cognitive engagement is associated with low beta-amyloid deposition

Archives of Neurology, epub Jan 23, 2012

Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O’Neil JP. Wilson RS. Jagust WJ

pubmed

[Landau2012_2]

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

Annals of Neurology 72:578-586, 2012

Landau SM, Mintun MA, Joshi AD, Koeppe RA, Petersen RC, Aisen PS, Weiner MW, Jagust WJ.

pubmed

[Landau2012_3]

Amyloid-β Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods.

Journal of Nuclear Medicine Jan;54(1):70-7 2012

Landau SM, Breault C, Joshi AD, Pontecorvo M, Mathis CA, Jagust WJ, Mintun MA; for the Alzheimer’s Disease Neuroimaging Initiative.

pubmed

[Lo2012]

Predicting missing biomarker data in a longitudinal study of Alzheimer disease

Neurology 78:1376-1382, 2012.

Lo RY, Jagust WJ.

pubmed

[Lo2012_2]

Vascular burden and Alzheimer pathological progression.

Neurology, Sep 25;79(13):1349-55 2012

Lo RY, Jagust WJ.

pubmed

[Mitchell2012]

Alcohol consumption induces endogenous opiod release in the human orbitofrontal cortex and nucleus accumbens

Science Translational Medicine, 11:116ra6, 2012

Mitchell JM, O’Neil JP, Janabi M, Marks SM, Jagust WJ, Fields HL

pubmed

[Mormino2012]

Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant

Neuroimage, 59:1152-1160, 2012

Mormino EC, Brandel MG, Madison CM, Rabinovici GD, Marks W, Baker SL, Jagust WJ

pubmed

[Oh2012]

Effects of age and β-amyloid on cognitive changes in normal elderly people

Neurobiology of Aging 2012

Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust

science direct

[Oh2012_2]

Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly

Human Brain Mapping, epub Sep 11, 2012

Oh H, Habeck C, Madison C, Jagust W

Human Brain Mapping Link

[Perrotin2012]

Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals

Arch Neurol. 2012 Feb;69(2):223-9.

Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ.

pubmed

Supplementary On-line Content

2011

[Albert2011]

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

Alzheimers Dement. 2011 May 7(3):270-9

Albert MS, Dekosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH.

pubmed

[Klostermann2011]

Dopamine and frontostriatal networks in cognitive aging.

Neurobiol Aging. 2011 Apr 19

Klostermann EC, Braskie MN, Landau SM, O’Neil JP, Jagust WJ.

pubmed

[Jagust2011]

Lifespan brain activity, beta-amyloid, and Alzheimer’s diseaes.

Jagust WJ and Mormino EC.

Trends in Cognitive Sciences 15:520-526, 2011 pubmed

[Lo2011]

Longitudinal Change of Biomarkers in Cognitive Decline.

Arch Neurol. 2011 Jun 13.

Lo RY, Hubbard AE, Shaw LM, Trojanowski JQ, Petersen RC, Aisen PS, Weiner MW, Jagust WJ; for the Alzheimer’s Disease Neuroimaging Initiative

pubmed

[Marchant2011]

Cerebrovascular disease, beta-amyloid and cognition in aging.

Marchant NL, Reed BR, DeCarli CS, Madison CM, Weiner MW, Chui HC, Jagust WJ

Neurobiol Aging. 2011 Oct 31. [Epub ahead of print] pubmed

[Mormino2011_2]

Ab deposition in aging is associated with increases in brain activation during successful memory encoding

Mormino EC, Brandel MG, Madison CM, Marks S, Baker SL, Jagust WJ

Cerebral Cortex, epub Sept 23, 2011 pubmed

[Mormino2011]

Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging.

Mormino EC, Smiljic A, Hayenga AO, H Onami S, Greicius MD, Rabinovici GD, Janabi M, Baker SL, V Yen I, Madison CM, Miller BL, Jagust WJ.

Cereb Cortex. 2011 Mar 7 pubmed

[Rabinovici2011]

Amyloid versus FDG-PET in the differential diagnosis of AD and FTLD

Rabinovici GD, Rosen HJ, Alkalay A, Kornak, J, Furst AJ, Agarwal N, Mormino EC, O’Neil JP, Janabi M, Karydas A, Growdon ME, Jang, JY, Huang EJ, DeArmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley, WW, Miller BL, Jagust WJ.

Neurology, 77: 2034-2042, 2011 pubmed

[Reed2011]

Coronary risk correlates with cerebral amyloid deposition

Reed BR, Marchant NL, Jagust WJ, DeCarli CS, Mack W, Chui HC

Neurobiology of Aging epub Nov 9, 2011 pubmed

[Rosenbloom2011]

Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution.

Rosenbloom MH, Alkalay A, Agarwal N, Baker SL, O’Neil JP, Janabi M, Yen IV, Growdon M, Jang J, Madison C, Mormino EC, Rosen HJ, Gorno-Tempini ML, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2011 May 24;76(21):1789-96. pubmed

[Rostomian]

Early 11C-PIB frames and 18F-FDG PET measures are comparable: a study validated in a cohort of AD and FTLD patients.

Rostomian AH, Madison C, Rabinovici GD, Jagust WJ.

J Nucl Med. 2011 Feb;52(2):173-9. pubmed

2010

[Braskie2010]

Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults.

Braskie MN, Landau SM, Wilcox CE, Taylor SD, O’Neil JP, Baker SL, Madison CM, Jagust WJ.

Hum Brain Mapp. 2010 Jun 24. pubmed

[Furst2010]

Cognition, glucose metabolism and amyloid burden in Alzheimer’s disease.

Furst AJ, Rabinovici GD, Rostomian AH, Steed T, Alkalay A, Racine C, Miller BL, Jagust WJ.

Neurobiol Aging. 2010 Apr 22. pubmed

[Furst2010_2]

A BOLD move: clinical application of fMRI in aging.

Furst AJ, Mormino EC.

Neurology. 2010 Jun 15;74(24):1969-76. pubmed

[Jack2010]

Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade.

Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ.

Lancet Neurol 9(1):119-28. pubmed

[Jagust2010]

The Alzheimer’s Disease Neuroimaging Initiative positron emission tomography core.

Jagust WJ, Bandy D, Chen K, Foster NL, Landau SM, Mathis CA, Price JC, Reiman EM, Skovronsky D, Koeppe RA; Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Dement. 2010 May;6(3):221-9. pubmed

[Landau2010]

Comparing predictors of conversion and decline in mild cognitive impairment.

Landau SM, Harvey D, Madison CM, Reiman EM, Foster NL, Aisen PS, Petersen RC, Shaw LM, Trojanowski JQ, Jack CR Jr, Weiner MW, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Neurology. 2010 Jul 20;75(3):230-8. pubmed

[Oh2010]

β-Amyloid affects frontal and posterior brain networks in normal aging.

Oh H, Mormino EC, Madison C, Hayenga A, Smiljic A, Jagust WJ.

Neuroimage. Oct 18. [Epub ahead of print]

[Petersen2010]

Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization.

Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, Jack CR Jr, Jagust WJ, Shaw LM, Toga AW, Trojanowski JQ, Weiner MW.

Neurology 74(3):201-9. pubmed

[Rabinovici2010]

Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden.

Rabinovici GD, Furst AJ, Alkalay A, Racine CA, O’Neil JP, Janabi M, Baker SL, Agarwal N, Bonasera SJ, Mormino EC, Weiner MW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ.

Brain. Jan 15. [Epub ahead of print] pubmed

2009

[Cools2009]

Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration

Cools R, Frank MJ, Gibbs SE, Miyakawa A, Jagust W, D’Esposito M.

Journal of Neuroscience 29:1538-1543 pubmed

[Haense2009]

Performance of FDG PET for detection of Alzheimer’s disease in two independent multicentre samples (NEST-DD and ADNI).

Haense C, Herholz K, Jagust WJ, Heiss WD.

Dement Geriatr Cogn Disord. 28(3):259-66. pubmed

[Jagust2009a]

Relationships between biomarkers in aging and dementia.

Jagust WJ, Landau SM, Shaw LM, Trojanowski JQ, Koeppe RA, Reiman EM, Foster NL, Petersen RC, Weiner MW, Price JC, Mathis CA; Alzheimer’s Disease Neuroimaging Initiative.

Neurology 73(15):1193-9. pubmed

[Jagust2009b]

Mapping brain beta-amyloid.

Jagust W.

Curr Opin Neurol 22(4):356-61. pubmed

[Landau2009_2]

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Landau SM, Harvey D, Madison CM, Koeppe RA, Reiman EM, Foster NL, Weiner MW,Jagust WJ, ADNI

Neurobiology of Aging 2009 Aug 4. [Epub ahead of print]** pubmed

[Landau2009]

Striatal dopamine and working memory.

Landau SM, Lal R, O’Neil, JP, Baker S, Jagust WJ.

Cerebral Cortex, 19:445-454. pubmed

[Kuczynski2009]

An inverse association of cardiovascular risk and frontal lobe glucose metabolism.

Kuczynski B, Jagust W, Chui HC, Reed, BR.

Neurology, 72:738-74. pubmed

2008

[Cools2008]

Working memory capacity predicts dopamine synthesis capacity in the human striatum

Cools R, Gibbs SE, Miyakawa A, Jagust W, D’Esposito M.

Journal of Neuroscience, 28:1208-1212 pubmed

[Braskie2008]

Relationship of striatal dopamine synthesis capacity to age and cognition.

Braskie MN, Wilcox CE, Landau SM, O’Neil JP, BakerSL, MadisonCM,Kluth JT, Jagust WJ

J Neurosci. 28(52):14320-8. pubmed

[Eberling2008]

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease.

Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ

Neurology. 2008 May 20;70(21):1980-3 pubmed

[Jagust2008]

Neuropathological basis of MR images in aging and dementia

Jagust WJ, Zheng L, Harvey DJ, Mack WJ, Vinters HV,Weiner MW, Ellis WG, Zarow C, Mungas D, Reed BR, Kramer JH, SchuffN, DeCarli C, Chui HC.

Annals of Neurology,63:72-80 pubmed

[Kuczynski2008]

Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease.

Kuczynski B, Reed B, Mungas D, Weiner M, Chui HC, Jagust W

Arch Neurol. 2008 May;65(5):650-5. pubmed

[Mormino2008]

Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.

Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ.

Brain, Nov 28 pubmed

[Rabinovici2008]

AB amyloid and glucose metabolism in three variants of primary progressive aphasia.

Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, O’Neil JP, Lal RA, Dronkers NF, Miller BL, Gorno-Tempini ML.

Annals of Neurology, 64: 388-401 pubmed

2007

[Rabinovici2007]

11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration.

Rabinovici GD, Furst AJ, O’Neil JP, Racine CA, Mormino EC, Baker SL, Chetty S, Patel P, Pagliaro TA, Klunk WE, Mathis CA, Rosen HJ, Miller BL, Jagust WJ,

Neurology, 68:1205-1212 pubmed

[Boxer2007]

Amyloid imaging in distinguishing atypical prion disease from Alzheimer’s disease.

Boxer AL, Rabinovici GD,Kepe V, Goldman J, Furst AJ, Huang SC, Baker SL, O’Neil JP, Chui H, Geschwind MD, Small GW, Barrio JR, Jagust W, Miller BL,

Neurology, 69: 283-290 pubmed

[Sun2007]

Automated template-based PET region of interest analyses in the aging brain.

Sun FT, Schriber RA, Greenia JM, He J, Gitcho A, Jagust WJ

Neuroimage. 2007 Jan 15;34(2):608-17 pubmed

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