Supplemental Data

Publication Timeline



Clustering-initiated factor analysis application for tissue classification in dynamic brain positron emission tomography

J Cereb Blood Flow Metab. 2015 Apr 22. doi: 10.1038/jcbfm.2015.69. [Epub ahead of print]

Boutchko R, Mitra D, Baker SL, Jagust WJ, Gullberg GT



Measurement of longitudinal Aβ change with 18F florbetapir PET and standard uptake value ratios

J Nucl Med. 2015 Apr;56(4):567-74

Landau SM, Fero A, Baker SL, Koeppe RA, Mintun M, Chen K, Reiman E, Jagust W



β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci. 2015 Jun 1. doi: 10.1038/nn.4035. [Epub ahead of print]

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP



Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy.

Ann Neurol. 2015 Feb;77(2):338-42.

Ossenkoppele R, Schonhaut DR, Baker SL, O’Neil JP, Janabi M, Ghosh PM, Santos M, Miller ZA, Bettcher BM, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD



Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment.

J Prev Alzheimers Dis. 2015 Mar;2(1):64-70

Villeneuve S, Jagust WJ



Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

Brain. 2015 May 6. pii: awv112. [Epub ahead of print]

Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh P, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen HJ, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin L, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust WJ



Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods.

Appetite. 2015 May 8;92:74-80. doi: 10.1016/j.appet.2015.05.004. [Epub ahead of print]

Wallace DL, Aarts E, d’Oleire Uquillas F, Dang LC, Greer SM, Jagust WJ, D’Esposito M




Dopamine and the cognitive downside of a promised bonus

Psychol Sci. 2014 Apr;25(4):1003-9

Aarts E, Wallace DL, Dang LC, Jagust WJ, Cools R, D’Esposito M



Neural compensation in older people with brain amyloid-β deposition

Nat Neurosci. 2014 Oct;17(10):1316-8

Elman JA, Oh H, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ



Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability

Cereb Cortex. 2014 Nov 7. pii: bhu259. [Epub ahead of print]

Elman JA, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O’Neil JP, Jagust WJ



Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers

Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1398-407

Landau SM, Thomas BA, Thurfjell L, Schmidt M, Margolin R, Mintun M, Pontecorvo M, Baker SL, Jagust WJ



Associations between serum cholesterol levels and cerebral amyloidosis

JAMA Neurology 71:195-200, 2014

Reed B, Villeneuve S, Mack W, DeCarli C, Chui HC, Jagust WJ



Cortical thickness mediates the effect of b-amyloid on episodic memory

Neurology 82:761-7, 2014

Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N, Mack W, Mungas D, Chui HC, DeCarli C, Weiner MW, Jagust WJ



Vascular risk and Ab interact to reduct cortical thickness in AD vulnerable brain regions

Neurology 83: 40-47, 2014

Villeneuve S, Reed BR, Madison CM, Wirth M, Marchant NL, Kriger S, Mack WJ, Sanossian N, DeCarli C, Chui HC, Weiner MW, Jagust WJ



Dorsal striatal dopamine, food preference and health perception in humans

PloS One May 7 9(5):e96319, 2014

Wallace DL, Aarts E, Dang LC, Greer SM, Jagust WJ, D’Esposito M



Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal adults

Neurobiology of Aging 35:1873-1882, 2014

Wirth M, Haase CM, Villeneuve S, Vogel J, Jagust WJ



Gene-Environment interactions: Lifetime cognitive activity, ApoE genotype and beta-amyloid burden

Journal of Neuroscience 34: 8612-8617, 2014

Wirth M, Villeneuve S, La Joie R, Marks SM, Jagust WJ




Vulnerable neural systems and the borderland of brain aging and neurodegeneration

Neuron 77:219-234, 2013

Jagust W



Comparing Positron Emission Tomography Imaging and Cerebrospinal Fluid Measurements of b-Amyloid

Ann Neurol. 2013 Dec;74(6):826-36

Landau SM, Lu M, Joshi AD, Pontecorvo M, Mintun MA, Trojanowski JQ, Shaw LM, Jagust WJ for the Alzheimer’s Disease Neuroimaging Initiative



Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease

Brain. 2013 Mar;136(Pt 3):844-58

Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD



Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

Journal of Neurology, Neurosurgery and Psychiatry Aug 21, 2013

Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O’Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD



Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer’s disease.

Proceedings of the National Academy of Sciences USA, 110:11606-11611, 2013

Lehmann M, Madison CM, Ghosh PM, Seeley WW, Mormino E, Greicius MD, Gorno-Tempini ML, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD



Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging

Nature Neuroscience 16:357-364, 2013.

Mander BA, Rao V, Lu B, Saletin JM, Lindquist JR, Ancoli-Israel S, Jagust W, Walker MP.



Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults

Cerebral Cortex July 30, 2013

Mander BA, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP



The aging brain and cognition: Contribution of vascular injury and Ab to mild cognitive dysfunction.

JAMA Neurology Apri 1, 2013

Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ



Association of gray matter atrophy with age, b-amyloid, and cognition in aging

Cerebral Cortex Feb 6 2013

Oh H, Madison C, Villeneuve S, Markley C, Jagust WJ



Frontotemporal Network Connectivity during Memory Encoding Is Increased with Aging and Disrupted by Beta-Amyloid.

J Neurosci. 2013 Nov 20

Oh H, Jagust WJ.



Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people

JAMA Neurology 70:1512-1519, 2013

Wirth M, Villeneuve S, Haase CM, Madison CM, Oh H, Landau SM, Rabinovici GD, Jagust WJ




Dopamine supports coupling of attention-related networks

Journal of Neuroscience, 32(28):9582-9587. (2012)

Dang LC, O’Neil JP, Jagust WJ.



Striatal dopamine influences the default mode network to affect shifting between object features

Journal of Cognitive Neuroscience, Sep;24(9):1960-70 2012

Dang LC, Donde A, Madison C, O’Neil JP, Jagust WJ.



Genetic effects on behavior are mediated by neurotransmitters and large-scale neural networks

Neuroimage, Nov 8;66C:203-214

Linh C Dang, James P O’Neil, and William J Jagust



Relative contributions of biomarkers in Alzheimer’s disease

Annals of Epidemiology 22:868-875, 2012

Haight TJ, Jagust WJ.



Apolipoprotein E, not fibrillar b-amyloid, reduces cerebral glucose metabolism in normal aging.

Journal of Neuroscience, 32:18227-18233, 2012.

Jagust WJ, Landau SM



Lifetime cognitive engagement is associated with low beta-amyloid deposition

Archives of Neurology, epub Jan 23, 2012

Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O’Neil JP. Wilson RS. Jagust WJ



Amyloid deposition, hypometabolism, and longitudinal cognitive decline

Annals of Neurology 72:578-586, 2012

Landau SM, Mintun MA, Joshi AD, Koeppe RA, Petersen RC, Aisen PS, Weiner MW, Jagust WJ.



Amyloid-β Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods.

Journal of Nuclear Medicine Jan;54(1):70-7 2012

Landau SM, Breault C, Joshi AD, Pontecorvo M, Mathis CA, Jagust WJ, Mintun MA; for the Alzheimer’s Disease Neuroimaging Initiative.



Predicting missing biomarker data in a longitudinal study of Alzheimer disease

Neurology 78:1376-1382, 2012.

Lo RY, Jagust WJ.



Vascular burden and Alzheimer pathological progression.

Neurology, Sep 25;79(13):1349-55 2012

Lo RY, Jagust WJ.



Alcohol consumption induces endogenous opiod release in the human orbitofrontal cortex and nucleus accumbens

Science Translational Medicine, 11:116ra6, 2012

Mitchell JM, O’Neil JP, Janabi M, Marks SM, Jagust WJ, Fields HL



Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant

Neuroimage, 59:1152-1160, 2012

Mormino EC, Brandel MG, Madison CM, Rabinovici GD, Marks W, Baker SL, Jagust WJ



Effects of age and β-amyloid on cognitive changes in normal elderly people

Neurobiology of Aging 2012

Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust

science direct


Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly

Human Brain Mapping, epub Sep 11, 2012

Oh H, Habeck C, Madison C, Jagust W

Human Brain Mapping Link


Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals

Arch Neurol. 2012 Feb;69(2):223-9.

Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ.


Supplementary On-line Content



The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

Alzheimers Dement. 2011 May 7(3):270-9

Albert MS, Dekosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH.



Dopamine and frontostriatal networks in cognitive aging.

Neurobiol Aging. 2011 Apr 19

Klostermann EC, Braskie MN, Landau SM, O’Neil JP, Jagust WJ.



Lifespan brain activity, beta-amyloid, and Alzheimer’s diseaes.

Jagust WJ and Mormino EC.

Trends in Cognitive Sciences 15:520-526, 2011 pubmed


Longitudinal Change of Biomarkers in Cognitive Decline.

Arch Neurol. 2011 Jun 13.

Lo RY, Hubbard AE, Shaw LM, Trojanowski JQ, Petersen RC, Aisen PS, Weiner MW, Jagust WJ; for the Alzheimer’s Disease Neuroimaging Initiative



Cerebrovascular disease, beta-amyloid and cognition in aging.

Marchant NL, Reed BR, DeCarli CS, Madison CM, Weiner MW, Chui HC, Jagust WJ

Neurobiol Aging. 2011 Oct 31. [Epub ahead of print] pubmed


Ab deposition in aging is associated with increases in brain activation during successful memory encoding

Mormino EC, Brandel MG, Madison CM, Marks S, Baker SL, Jagust WJ

Cerebral Cortex, epub Sept 23, 2011 pubmed


Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging.

Mormino EC, Smiljic A, Hayenga AO, H Onami S, Greicius MD, Rabinovici GD, Janabi M, Baker SL, V Yen I, Madison CM, Miller BL, Jagust WJ.

Cereb Cortex. 2011 Mar 7 pubmed


Amyloid versus FDG-PET in the differential diagnosis of AD and FTLD

Rabinovici GD, Rosen HJ, Alkalay A, Kornak, J, Furst AJ, Agarwal N, Mormino EC, O’Neil JP, Janabi M, Karydas A, Growdon ME, Jang, JY, Huang EJ, DeArmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley, WW, Miller BL, Jagust WJ.

Neurology, 77: 2034-2042, 2011 pubmed


Coronary risk correlates with cerebral amyloid deposition

Reed BR, Marchant NL, Jagust WJ, DeCarli CS, Mack W, Chui HC

Neurobiology of Aging epub Nov 9, 2011 pubmed


Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution.

Rosenbloom MH, Alkalay A, Agarwal N, Baker SL, O’Neil JP, Janabi M, Yen IV, Growdon M, Jang J, Madison C, Mormino EC, Rosen HJ, Gorno-Tempini ML, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2011 May 24;76(21):1789-96. pubmed


Early 11C-PIB frames and 18F-FDG PET measures are comparable: a study validated in a cohort of AD and FTLD patients.

Rostomian AH, Madison C, Rabinovici GD, Jagust WJ.

J Nucl Med. 2011 Feb;52(2):173-9. pubmed



Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults.

Braskie MN, Landau SM, Wilcox CE, Taylor SD, O’Neil JP, Baker SL, Madison CM, Jagust WJ.

Hum Brain Mapp. 2010 Jun 24. pubmed


Cognition, glucose metabolism and amyloid burden in Alzheimer’s disease.

Furst AJ, Rabinovici GD, Rostomian AH, Steed T, Alkalay A, Racine C, Miller BL, Jagust WJ.

Neurobiol Aging. 2010 Apr 22. pubmed


A BOLD move: clinical application of fMRI in aging.

Furst AJ, Mormino EC.

Neurology. 2010 Jun 15;74(24):1969-76. pubmed


Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade.

Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ.

Lancet Neurol 9(1):119-28. pubmed


The Alzheimer’s Disease Neuroimaging Initiative positron emission tomography core.

Jagust WJ, Bandy D, Chen K, Foster NL, Landau SM, Mathis CA, Price JC, Reiman EM, Skovronsky D, Koeppe RA; Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Dement. 2010 May;6(3):221-9. pubmed


Comparing predictors of conversion and decline in mild cognitive impairment.

Landau SM, Harvey D, Madison CM, Reiman EM, Foster NL, Aisen PS, Petersen RC, Shaw LM, Trojanowski JQ, Jack CR Jr, Weiner MW, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative.

Neurology. 2010 Jul 20;75(3):230-8. pubmed


β-Amyloid affects frontal and posterior brain networks in normal aging.

Oh H, Mormino EC, Madison C, Hayenga A, Smiljic A, Jagust WJ.

Neuroimage. Oct 18. [Epub ahead of print]


Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization.

Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, Jack CR Jr, Jagust WJ, Shaw LM, Toga AW, Trojanowski JQ, Weiner MW.

Neurology 74(3):201-9. pubmed


Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden.

Rabinovici GD, Furst AJ, Alkalay A, Racine CA, O’Neil JP, Janabi M, Baker SL, Agarwal N, Bonasera SJ, Mormino EC, Weiner MW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ.

Brain. Jan 15. [Epub ahead of print] pubmed



Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration

Cools R, Frank MJ, Gibbs SE, Miyakawa A, Jagust W, D’Esposito M.

Journal of Neuroscience 29:1538-1543 pubmed


Performance of FDG PET for detection of Alzheimer’s disease in two independent multicentre samples (NEST-DD and ADNI).

Haense C, Herholz K, Jagust WJ, Heiss WD.

Dement Geriatr Cogn Disord. 28(3):259-66. pubmed


Relationships between biomarkers in aging and dementia.

Jagust WJ, Landau SM, Shaw LM, Trojanowski JQ, Koeppe RA, Reiman EM, Foster NL, Petersen RC, Weiner MW, Price JC, Mathis CA; Alzheimer’s Disease Neuroimaging Initiative.

Neurology 73(15):1193-9. pubmed


Mapping brain beta-amyloid.

Jagust W.

Curr Opin Neurol 22(4):356-61. pubmed


Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Landau SM, Harvey D, Madison CM, Koeppe RA, Reiman EM, Foster NL, Weiner MW,Jagust WJ, ADNI

Neurobiology of Aging 2009 Aug 4. [Epub ahead of print]** pubmed


Striatal dopamine and working memory.

Landau SM, Lal R, O’Neil, JP, Baker S, Jagust WJ.

Cerebral Cortex, 19:445-454. pubmed


An inverse association of cardiovascular risk and frontal lobe glucose metabolism.

Kuczynski B, Jagust W, Chui HC, Reed, BR.

Neurology, 72:738-74. pubmed



Working memory capacity predicts dopamine synthesis capacity in the human striatum

Cools R, Gibbs SE, Miyakawa A, Jagust W, D’Esposito M.

Journal of Neuroscience, 28:1208-1212 pubmed


Relationship of striatal dopamine synthesis capacity to age and cognition.

Braskie MN, Wilcox CE, Landau SM, O’Neil JP, BakerSL, MadisonCM,Kluth JT, Jagust WJ

J Neurosci. 28(52):14320-8. pubmed


Results from a phase I safety trial of hAADC gene therapy for Parkinson disease.

Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ

Neurology. 2008 May 20;70(21):1980-3 pubmed


Neuropathological basis of MR images in aging and dementia

Jagust WJ, Zheng L, Harvey DJ, Mack WJ, Vinters HV,Weiner MW, Ellis WG, Zarow C, Mungas D, Reed BR, Kramer JH, SchuffN, DeCarli C, Chui HC.

Annals of Neurology,63:72-80 pubmed


Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease.

Kuczynski B, Reed B, Mungas D, Weiner M, Chui HC, Jagust W

Arch Neurol. 2008 May;65(5):650-5. pubmed


Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.

Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ.

Brain, Nov 28 pubmed


AB amyloid and glucose metabolism in three variants of primary progressive aphasia.

Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, O’Neil JP, Lal RA, Dronkers NF, Miller BL, Gorno-Tempini ML.

Annals of Neurology, 64: 388-401 pubmed



11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration.

Rabinovici GD, Furst AJ, O’Neil JP, Racine CA, Mormino EC, Baker SL, Chetty S, Patel P, Pagliaro TA, Klunk WE, Mathis CA, Rosen HJ, Miller BL, Jagust WJ,

Neurology, 68:1205-1212 pubmed


Amyloid imaging in distinguishing atypical prion disease from Alzheimer’s disease.

Boxer AL, Rabinovici GD,Kepe V, Goldman J, Furst AJ, Huang SC, Baker SL, O’Neil JP, Chui H, Geschwind MD, Small GW, Barrio JR, Jagust W, Miller BL,

Neurology, 69: 283-290 pubmed


Automated template-based PET region of interest analyses in the aging brain.

Sun FT, Schriber RA, Greenia JM, He J, Gitcho A, Jagust WJ

Neuroimage. 2007 Jan 15;34(2):608-17 pubmed

Table Of Contents

Previous topic


Next topic

Contact the Lab

This Page