People

_images/lab_photo_june2013_sm.jpg _images/jagust_award.jpg

Faculty

bill William Jagust

The Boss and Our Benevolent Dictator

Fellows

elman Jeremy Elman

I received my PhD from UC Berkeley in 2012 under Arthur Shimamura. My doctoral research investigated contributions of the posterior parietal cortex to episodic memory using fMRI. As part of the Jagust lab, my research focuses on alterations in cognitive performance and multi-modal imaging biomarkers as a function of beta-amyloid deposition employing techniques that include structural MRI, task-based and resting-state fMRI, and PIB-PET.

Papers

Elman, J. A., Cohn-Sheehy, B. I., & Shimamura, A. P. (2013). Dissociable parietal regions facilitate successful retrieval of recently learned and personally familiar information. Neuropsychologia, 51(4), 573–583. doi:10.1016/j.neuropsychologia.2012.12.013 pubmed

Elman, J. A., Klostermann, E. C., Marian, D. E., Verstaen, A., & Shimamura, A. P. (2012). Neural correlates of metacognitive monitoring during episodic and semantic retrieval. Cognitive, Affective, & Behavioral Neuroscience, 1–11. doi:10.3758/s13415-012-0096-8 pubmed

Elman, J. A., & Shimamura, A. P. (2011). Task relevance modulates successful retrieval effects during explicit and implicit memory tests. NeuroImage, 56(1), 345–353. doi:10.1016/j.neuroimage.2011.02.017 pubmed


renaud Renaud La Joie

After spending five years studying patients with Alzheimer’s disease using hippocampal subfield measurement, structural MRI, Florbetapir-PET and FDG-PET under the rainy and cloudy sky of Normandy with Gaël Chételat.

I arrived in Jagust lab in may 2013 to experience Californian weather. And also potentially to study the impact of beta-amyoid on brain function in healthy aged people.

Publications

Region-specific hierarchy between atrophy, hypometabolism, and β-amyloid (Aβ) load in Alzheimer’s disease dementia.

Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence.


hwamee Hwamee Oh

hwameemail

My research in the Jagust lab examines cognitive, structural, and functional alterations in relation to normal aging and pathological aging involving beta-amyloid deposition using multimodality imaging techniques of PIB-PET, FDG-PET, structural MRI, and fMRI and neuropsychological tests.

Prior to the Jagust lab, I received my PhD from SUNY-Stony Brook in 2009,where I worked with Hoi-Chung Leung. My doctoral research focused on the behavioral and neural bases of working memory, specifically, executive processes and an interaction of visual and verbal representations in healthy young adults.

Papers

[Oh2013_2] Frontotemporal Network Connectivity during Memory Encoding Is Increased with Aging and Disrupted by Beta-Amyloid. Oh H, Jagust WJ. J Neurosci. 2013 Nov 20 pubmed

[Oh2013] Association of gray matter atrophy with age, b-amyloid, and cognition in aging Oh H, Madison C, Villeneuve S, Markley C, Jagust WJ. Cereb Cortex. 2013 Feb 6. pubmed

[Oh2012_2] Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly Oh H, Habeck C, Madison C, Jagust W Human Brain Mapping, epub Sep 11, 2012 Human Brain Mapping Link

[Oh2012] Effects of age and β-amyloid on cognitive changes in normal elderly people (2012) Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust Neurobiology of Aging 2012 science direct

[Oh2010] Beta-Amyloid affects frontal and posterior brain networks in normal aging. (2010) Oh H, Mormino EC, Madison C, Hayenga A, Smiljic A, Jagust WJ. Neuroimage. 2010 Oct 18 pubmed


steffi Stephanie Schreiber

At the Otto-von-Guericke University, Magdeburg, Germany (head: Prof. Hans-Jochen Heinze) I am working as neurologist, received my PhD in 2007 and finished my habilitation in 2014. During my habilitation I investigated the natural course of cerebral small vessel disease and its interplay with beta-amyloid-pathology in a hypertensive rat model. I came to the Jagust lab to learn biomarker PET and multimodal imaging techniques. My research in the lab will potentially focus on the interplay between biomarkers of neurodegeneration and of cerebral small vessel disease in the non-demented elderly.

Papers

Schreiber et al. Sonography of the median nerve in CMT1A, CMT2A, CMTX and HNPP. Muscle Nerve. 2013 Mar;47(3):385-95. http://www.ncbi.nlm.nih.gov/pubmed/23381770

Schreiber et al. The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? J Cereb Blood Flow Metab. 2012 Feb;32(2):278-90. http://www.ncbi.nlm.nih.gov/pubmed/21878945


monika Monika Varga Doležalová

Working as a psychologist in Neurology clinic in my homeland I felt it would be meaningful to zoom out and see what was really happening in a big and progressive world of neuroscience. This has happened to be real thanks to a Fulbright grant. Being a visiting student researcher, my main interest is cognitive neuroscience, but cannot wait to learn more about neuroimaging!


sylvia Sylvia Villeneuve

villeneuve dot sylvia at gmail dot com

Https://sites.google.com/site/villeneuvesylvia/

I completed a Ph.D. in Neuropsychology at University of Montreal in 2011, with Dr. Sylvie Belleville. My doctoral work focused on the impact of vascular diseases on the cognitive profile of persons with mild cognitive impairment.

My main goal in the Jagust lab is to learn PIB-PET and FDG-PET imaging techniques. My research will examine the interaction between beta-amyloid deposition, glucose metabolism, vascular diseases and genetic factors, and their impact on neuropsychological measures and cognitive status.

Papers

The nature of memory failure in mild cognitive impairment: examining association with neurobiological markers and effect of progression. Villeneuve S, Belleville S. Neurobiol Aging. 2011 Nov 14. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22088679

Villeneuve et al. Cortical thickness mediates the effect of β-amyloid on episodic memory. Neurology. 2014 Jan 31. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/24489134


miranka Miranka Wirth

Personal Website

I am a postdoctoral fellow at the Jagust Lab (PI: Prof. William Jagust), Helen Wills Neuroscience Center, University of California, Berkeley.

A central focus of my research work is to understand normal aging, detect pathological aging and identify life-style as well as genetic factors that contribute to differential aging of neural and cognitive functions.

I have trained in multimodal neuroimaging, including structural and functional task- and resting-state MRI, EEG, PET and non-invasive stimulation techniques, such as tDCS and TMS. At the Jagustlab, I am using biomarkers of PIB and FDG PET together with structural MRI to study the stage of preclinical Alzheimer’s disease in cognitively normal older individuals.

Posters

AAIC 2013 poster (pdf)

Visiting Scholars

gil Gil Rabinovici

gilmail

Regularly visits from UCSF, Stanford Alum, Cubs fan!

Papers

[Rabinovici2011] Amyloid versus FDG-PET in the differential diagnosis of AD and FTLD

[Rabinovici2010] Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden

[Rabinovici2008] AB amyloid and glucose metabolism in three variants of primary progressive aphasia



Graduate Students


begany Katelyn Begany

Katelyn has joined our lab and plans to continue working on relating FDG with network modularity in an older cognitively normal cohort.


shawn2 Shawn Marks

marksmail

Back for another round of research, stay tuned for exciting findings.

Staff

samia Samia K. Arthur-Bentil

Samia pioneers the reconstruction of the lab’s PET scan data and is here to explore the mystery of neurodegenerative disease via command line interfaces. When not bonding with her Sun, she enjoys dancing, searching for her new favorite restaurant and having intellectual conversations about bad television.


suzanne Suzanne Baker

Suzanne swims with the sharks and will devour wimpy little men all while juggling MRI and PET scanners!


brendan Brendan Cohn-Sheehy

Brendan is a recent UC Berkeley graduate who is looking forward to an exciting career in neurology practice and research, and is interested in everything from neurodegeneration to the cognitive neuroscience of music. When not analyzing PET and MRI data, he writes, records, and performs music and poetry.

Posters

AAIC 2013 talk (pdf)

AAIC 2013 poster (pdf)


sam Sam Crowley

Sam is spends his time in the lab on neuropsychological testing and helping with PET scans. When not working he can be found scarfing down a bratwurst from Top Dog or flipping through the vinyl at Amoeba.


allie Allie Fero

I just graduated from Berkeley with a degree in physics. I’m here to help with PET scan image analysis, and hopefully learn a little about neuroscience while I’m at it. When I’m not here or at home I’m probably out trying new restaurants in San Francisco or skiing up in Tahoe (or trying new restaurants in Tahoe).


pia Pia Ghosh

Pia works with Gil to pair clinical findings with brain imaging analysis to improve early stage diagnosis. Traveling to new places and music keep her pulse dancing.


susan Susan Landau

slandaumail

Research and Background

Papers

[Landau2012] Lifetime cognitive engagement is associated with low beta-amyloid deposition

[Landau2012_2] Amyloid deposition, hypometabolism, and longitudinal cognitive decline

[Landau2012_3] Amyloid-b Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods

[Landau2009_2] Associations between cognitive, functional, and FDG-PET measures of decline in AD and MC


cindee Cindee Madison

cindeemail

She codes and loves Python

Enjoys vim

Want to learn python?? IPython, and very useful ipython notebooks

Python in Berkeley python.berkeley.edu

Or join me at the py4science meeting

my blog rationalgirl.com


kris Kristin Norton

Kris is a radiologist specialist working to collect PET data.


henry Henry Schwimmer

henrymail

When not in the lab, he can be found shredding the gnar in Tahoe or hiking the backcountry with his harmonica. Online chatters beware: he despises emoticons.


jacob Jacob Vogel

Graduated from Hampshire College with a degree in Neuroscience. Interests include Clinical Neuro, Neuroendocrinology, Neuroimaging and Statistics. Currently managing Dr. Jagust’s lab and investigating subtle links between cognition and brain pathology in normally aging individuals. When not nerding out, you can find him recording music or watching a Phillies game.


Undergraduate Assistants

nagehan Nagehan Ayakta

Double majoring in MCB Neuroscience and Psychology; fascinated with the brain and hopes to receive a Ph. D. in neuropsychology to research why people behave the way they do. Outside of school and working, she loves to discover new bands and go concert hoping.


jessica Jessica Dai

april April Kiyomi Hishinuma

April is majoring in cognitive science with an emphasis in neuroscience. Her love for the brain has lead her to pursue an occupation in both research and health care. She aspires to learn as much as she can about the brain before attending medical school. When not found studying, she will usually be spotted working out at the gym, singing with her guitar, or eating with friends.


andreas Andreas Lazaris

tanu Tanu Patel

daniel Daniel Schonhaut

I studied psychology at UCLA and am here to learn fMRI data analysis and anything else I can pick up along the way. Other things I am working on right now include winning my fantasy soccer league without putting Luis Suarez on my team, trying every kind of coffee from Philz, and guessing what the next season of American Horror Story will be about.


helaine Helaine St. Amant

Helaine is a senior undergraduate student majoring in Molecular and Cell Biology with an emphasis in Neurobiology. She is fascinated by the complexity of the brain and hopes to learn as much as she can before attending medical school. Aside from school and the lab, she likes to spend her free time by getting outside and relaxing with friends and family. Go Bears!


gautam Gautam Tammewar

angie Angie Yi

I’m a 3rd year majoring in MCB - Neuro. Aspiring to attend pharmacy school after graduating. I love studying about the brain and cognitive function. I hope to attain a MA/PhD in Neuroscience in the future.

Alumni

scott Scott Roberts

Scott Roberts, PhD came to the Jagust Lab from the University of Michigan School of Public Health, where he is Associate Professor of Health Behavior and Health Education. Dr. Roberts’ research addresses ethical and psychosocial issues involved in disclosing genetic risk information for adult-onset conditions, with Alzheimer’s disease as a primary focus. He is Co-PI of the longstanding REVEAL (Risk Evaluation and Education for Alzheimer’s Disease) Study, a NIH-funded series of randomized clinical trials examining the psychological and behavioral impact of APOE genotyping on first-degree relatives of people with AD. He also serves on ethics advisory boards for forthcoming large-scale AD prevention trials including the A4 Study and Alzheimer’s Prevention Initiative.


andrea Andrea Long

Andrea has been called back to a position in a top secret lab who existence is still denied. She is assisting in the lab part-time, but only if we don’t ask her about the secret lab.


samg Sam Greene

tad Tad Haight

Tad has moved on to a post-doc at the NIH on the other side of the states. Everyone will miss his insight on statistical analysis.

Papers

Relative contributions of biomarkers in Alzheimer’s Disease. Haight, TJ, Jagust, WJ. Annals of Epidemiology (2012)22:868-875

Dissociable effects of Alzheimer’s Disease and White Matter Hyperintensities on Brain Metabolism. Haight, T, Landau,S, Carmichael, O,Schwarz, C, DeCarli, C, Jagust, W. JAMA Neurology (2013) 70(8): 1039-1045


manja Manja Lehmann

Manja was a visiting research scholar from London (UK) who joined the Memory and Aging Center at UCSF in October 2011. She continues her postdoctoral work at the Dementia Research Center at University College London: http://www.ucl.ac.uk/drc.

Her research aims to investigate functional connectivity networks in the brain, in particular in patients with different variants of Alzheimer’s disease, including Posterior Cortical Atrophy (visual variant), Logopenic Progressive Aphasia (language variant), and typical Alzheimer’s disease (amnestic variant).

Papers

[Lehmann2013] Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD Brain. 2013 Mar;136(Pt 3):844-58


caleb Caleb Wang

gracetmt Grace Tang

Grace presented a wonderful paper for her Honors thesis.

Cognitive Phenotypes and AD Biomarkers in Healthy Adults CSSA Poster (pdf)

Honors Thesis (pdf)

Grace is continuing to impress while studying Cell Biology in Graduate School at ETH in Switzerland. She is planning to focus her research on neuropathies.


tricia Tricia Ngoon

Tricia graduated, and is now working as a Research Assistant at the Stanford Cognitive and Systems Neuroscience Laboratory to examine the development and improvement of math abilities in children.


Hyesoo Youn

Hyesoo rotated through our lab from MCB, and investigated the deposition pattern of Beta Amyloid in a cognitively normal old cohort.


Elizabeth Counterman

Elizabeth rotated in the lab looking at the relationship between Beta Amyloid and three intrinsically connected networks (Default Mode, Dorsal Attention, Frontal Parietal Control Network ).


Linh Cat Dang

Linh has moved to a post-doc at Vanderbilt University where she will continue with her work on Dopamine


Rik Ossenkoppele

Rik has returned to VU University medical center in Amsterdam (Alzheimer center and department of Nuclear Medicine & PET Research) after a very productive 6 months of research and teaching the Americans how to play a proper game of soccer. He will be sorely missed.

Presentations

Award Winning Talk

Increased Parietal Amyloid Burden and Metabolic Dysfunction in Alzheimer’s Disease with Early Onset SNM2012 (pdf)

Papers

Amyloid burden and metabolic function in early-onset Alzheimer’s disease: parietal lobe involvement (2012) Ossenkoppele R et al. Brain. 2012 Jul :2115-25 pubmed

Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET. Ossenkoppele R et al. Eur J Nucl Med Mol Imaging. 2012 Jun;39(6):990-1000. pubmed


Candace Markley

Candace has left us for warmer temps, and there is still a secret list for people who want her to be their doctor once she finishes up at Emory Medical School....its a long list


Aneesh Donde

Aneesh has come under the influence of the Jagust love of research and decided against Medical School. You can now find him pursuing a PhD at Johns Hopkins.


Raymond Lo

Has finished his PhD with great style, and returned to research closer to his wife and son. Still holds the lab record for most quickly accepted manuscript (less than 24 hours)


Roxana Dhada

Tiffany Truong

Student Presentation

Dopamine-mediated networks


Michael Brandel

Graduated and working in a UCSF schizophrenia lab.


Chiara Martina Corbetta-Rastelli

Jiann Mok

Moved on to exploring user-interfaces


Natalie Marchant

Natalie has left us for an amazing globe-stomping adventure.

Papers

[Marchant2011] Cerebrovascular disease, beta-amyloid and cognition in aging.

Marchant, N.L., King, S.L., Tabet, N., & Rusted, J.M. (2010). Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers. Neuropsychopharmacology. 2010 Apr;35(5) pubmed

Presentations and Posters

Imaging Amyloid and Cerebrovascular Disease in Aging (Featured Research presentation at the Alzheimer’s Association International Conference. Paris, France, 2011)

Contribution of Vascular Brain Injury and Brain Aβ to Cognitive Function. (Human Amyloid Imaging 2012.)

Vascular Disease and Amyloid Imaging in Cognitive Aging (SFN 2010 .pdf)


Benedicte Rossi

Benedicte has her hands full with Carmen, and exciting new aspects of science to explore.


Courtney Gallen

Courtney is a first year graduate student in the Helen Wills Neuroscience Institute. Her project while rotating in the Jagust Lab investigated FDG hypometabolism associated with fMRI task activation in a Healthy Elderly Cohort with Amyloid burden.


Elizabeth Mormino

http://ecmormino.com/



Neha Agarwal

Scott Wilson

Adi Alkalay

Adi is returning to the homeland to complete her medical residency, as soon as she finishes her third genetic research project. She will be missed.


Irene Yen

Has left the Academic world to explore the exciting fast-paced world of start-ups, working with educational software.


George Zhang

Worked with Suzanne on PIB, but has left to loftier pursuits


Amynta Hygenga

Amynta has left us for Graduate School to pursue a career in Clinical Psychology, though she already proved her skills by handling the behavioral disorders of the researchers in our lab.


Luca Dellavedova

Returned to the University of Milan where he is a resident in Nuclear Medicine


Martina Studer

Returned to Switzerland to finish her PhD.


Ellen Klostermann Wallace

Ellen recently left the cool warmth of Berkeley for the balmy snow of Chicago, she is deeply missed. Here is a recent presentation she had.

Caudate Dopamine Release is Correlated with Frontal Lobe fMRI Activity and Performance During a Two-Back Working Memory Task (SFN 2010 .pdf)


Matar Davis

Matar rotated through our lab as a first year graduate student.


Ara Hrire Rostomian

Left us for UCLA Medical School


Susan Onami

Heading to Medical School at USCD, another one lost despite the seductive pull of the dark side.


Andre Smiljic

Heading to Medical School at UC Davis, despite our efforts to turn him to the dark side.


Ansgar Furst

The Pibster!

Has moved to Stanford/ VA Palo Alto


Audrey Perrotin

Mistress of Meta-Memory

Has left us for the Universoty of Caen in her native France


Meredith Braskie

Now at UCLA


Jamie Eberling

Now at Michael J. Fox Foundation


Beth Kuczynski

Now at UC Davis


Rayhan Lal

Talented young scientist, uniquely able to explain the physics, unravel the plot twists and expound upon the complex and deeper meaning of LOST through a series of power point presentations.

We begged him to stay, but he left us for medical school at UC Davis.


Dennis Nguyen

Medical Student UCSF


Michael Rosenbloom

Clinical Fellow/Neurologist from UCSF


Hermona Soreq

Visiting Miller Professor She has returned to Israel Research Page


Anthony Sossong

Medical Student UCSF


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