My research focuses on understanding why cognitive flexibility, the ability to dynamically respond to new task demands, declines with age. I am examining factors such as decreases in brain volume, dysregulation of the neurotransmitter dopamine, and changes in brain network activity.
I completed my PhD at the University of Michigan where I worked with Drs. Cindy Lustig and Martin Sarter. Broadly, my doctoral research investigated the contribution of the neurotransmitter acetylcholine to the control of attention.
I received my Ph.D. in Psychological & Brain Sciences at Johns Hopkins University in the Translational Neurobiology Lab under the direction of Dr. Michael Yassa. I examined the emotional modulation of episodic memory and translational applications to aging and depression-related cognitive impairment using a novel emotional memory task along with high-resolution fMRI.
My research in the Jagust Lab focuses on the influence of tau pathology on memory consolidation in cognitively normal aging. I utilize high-resolution fMRI methods in combination with tau PET imaging to elucidate tau’s effects on hippocampal subfield functioning.
Leal, S.L., Tighe, S.K., Jones, Craig K., & Yassa, M.A. (2014). Pattern separation of emotional information in hippocampal dentate/CA3. Hippocampus. 24: 1146-1155.
Leal, S.L & Yassa, M. (2015). Neurocognitive Aging and the Hippocampus Across Species. Trends in Neuroscience. 38(12), 800-812.
Leal, S.L., Noche, J.A., Murray, E.A., & Yassa, M.A. (2016). Positivity effect specific to older adults with subclinical memory impairment. Learning & Memory.
My research project in the Jagust lab examines neuroimaging biomarkers of preclinical Alzheimer’s Disease (AD). Preclinical progression along the AD pathological cascade may be inadvertently conflated with the normal aging process in many studies seeking to understand the causes of gradual cognitive decline late in life. Therefore, our goal is to investigate effects of tau and Aβ accumulation (measured using PET) on structural connectivity between these regions (measured using MRI and DTI), and the relative effects of these brain differences on memory performance.
I earned my PhD from UC Davis in 2014, working with Dr. Charles DeCarli to investigate the contributions of age and CVD-related white matter injury (white matter hyperintensities or WMH) to attentional control network function and cognitive performance.
The ability to form memories for novel experiences is supported by regions within the medial temporal lobe (MTL), which are also differentially and early to be affected in aging and age-related diseases. During my PhD in Magdeburg in the lab of Emrah Düzel, I tried to disentangle how new memories are formed within MTL subregions by making use of the very high resolution provided by 7 Tesla fMRI. Moreover, I investigated the effects of exercise training on vascular and structural hippocampal plasticity in older adults. My current research in the Jagust Lab now aims to unravel how age-related tau and Aß deposition contribute to functional changes within MTL memory pathways, using high-resolution fMRI at 3 Tesla.
Maass, A., Berron, D., Libby, L., Ranganath, C. & Düzel, E. Functional subregions of the human entorhinal cortex. Elife 4, (2015).
Maass, A. et al. Vascular hippocampal plasticity after aerobic exercise in older adults. Mol. Psychiatry (2014).
Maass, A. et al. Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding. Nat Commun 5, 5547 (2014).
Rik completed his PhD under Bart van Berkel at the VUMC in Amsterdam. He currently splits his time and talent between San Fransicso and Amsterdam, using various neuroimaging modalities to better understand neurodegenerative diseases associated with aging. He is an avid fan of the AFC Ajax, a burgeoning movie star, and an expert in men’s fashion.
michael dot scholl at berkeley dot edu
Michael swapped Swedish Västkust with American West Coast to finally see some light on the imaging horizon. Whenever he is not trying to convince people that PET is not an animal, he tries to get his hands on anything musical.
At the Otto-von-Guericke University, Magdeburg, Germany (head: Prof. Hans-Jochen Heinze) I am working as neurologist, received my PhD in 2007 and finished my habilitation in 2014. During my habilitation I investigated the natural course of cerebral small vessel disease and its interplay with beta-amyloid-pathology in a hypertensive rat model. I came to the Jagust lab to learn biomarker PET and multimodal imaging techniques. My research in the lab will potentially focus on the interplay between biomarkers of neurodegeneration and of cerebral small vessel disease in the non-demented elderly.
Schreiber et al. Sonography of the median nerve in CMT1A, CMT2A, CMTX and HNPP. Muscle Nerve. 2013 Mar;47(3):385-95. http://www.ncbi.nlm.nih.gov/pubmed/23381770
Schreiber et al. The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? J Cereb Blood Flow Metab. 2012 Feb;32(2):278-90. http://www.ncbi.nlm.nih.gov/pubmed/21878945
Regularly visits from UCSF, Stanford Alum, Cubs fan!
[Rabinovici2011] Amyloid versus FDG-PET in the differential diagnosis of AD and FTLD
[Rabinovici2010] Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden
[Rabinovici2008] AB amyloid and glucose metabolism in three variants of primary progressive aphasia
Katelyn Arnemann (Begany)
I’m a PhD candidate in the Neuroscience Program at UC Berkeley. Employing multimodal brain imaging of age-/disease-related perturbations, my research aims to uncover (ideally fundamental) links between brain networks, cognition, and pathology.
Back for another round of research, stay tuned for exciting findings.
Alex is a masters student in Epidemiology and Biostatistics investigating brain function using a combination of genetic and imaging methods.
I recently graduated from Cal after doing my honors thesis in the Jagust Lab on the pattern of beta-amyloid deposition. Now after an exciting summer traveling in Europe, I am back in the lab working with Gil Rabinovici on processing exciting PET data, including PIB, FDG, and tau. Outside of work, I love to cook, travel, and read.
Suzanne swims with the sharks and will devour wimpy little men all while juggling MRI and PET scanners!
Rachel graduated from Boston University with a B.A. in Neuroscience. A week later, she moved to the West Coast to become the new Jagust Lab manager! In her free time she loves hiking, camping, rock climbing, cooking, and wandering around book stores.
Mark does stats for the lab up in LBL. He went to school in the cold wintry lands of Chicago but grew up in the warmer climes of Austin, Texas. Outside of work, Mark enjoys going to shows, drawing, and foraging for trinkets, spices, and relics in the numerous flea markets and local shops in the East Bay.
I studied Cognitive Science and EECS at Cal, ran off to the tech industry for a few years, then happily returned to assist in PET analysis. I like to swim, jam sesh, build forecasting models, and loudly discuss basketball.
Assistant Research Scientist
slandau at berkeley dot edu
[Landau2015]_Measurement of longitudinal Aβ change with 18F florbetapir PET and standard uptake value ratios
[Landau2014] Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers
[Landau2013] Comparing Positron Emission Tomography Imaging and Cerebrospinal Fluid Measurements of b-Amyloid
[Landau2012] Lifetime cognitive engagement is associated with low beta-amyloid deposition
[Landau2012_2] Amyloid deposition, hypometabolism, and longitudinal cognitive decline
[Landau2012_3] Amyloid-b Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods
[Landau2010] Comparing predictors of conversion and decline in mild cognitive impairment
[Landau2009_2] Associations between cognitive, functional, and FDG-PET measures of decline in AD and MC
I recently graduated from UC Davis with a B.S. in Neurobiology, Physiology, and Behavior. I’m excited to be here to help out with neuropsychological testing and neuroimaging. When not in the lab, I enjoy traveling, hiking, exploring the city, and spending time with my friends and family.
I studied Public Health and English at Cal, but I’m eager to learn about anything and everything. I’m particularly interested in exploring how computational methods can be used to better understand the brain and the progression of aging. In my free time, I enjoy reading, writing, and giggling at lame puns (the real reason I enjoy Shakespeare so much).
Kris is a radiologist specialist working to collect PET data.
I studied psychology at UCLA and am here to learn fMRI data analysis and anything else I can pick up along the way. Other things I am working on right now include winning my fantasy soccer league without putting Luis Suarez on my team, trying every kind of coffee from Philz, and guessing what the next season of American Horror Story will be about.
As an undergrad here at Cal, I loved the interdisciplinary nature of Cognitive Science. I am fascinated by the intricacies and complexities of a ~3 pound piece of flesh we call the brain. I aim to better understand how it works, and apply these understandings to come up with meaningful innovations in the field of public health. Outside of the lab, you’re likely to find me playing Scrabble or Chess, enjoying chai tea, chocolate or cheese, traveling, or just exploring new places in the city with friends.
I recently graduated from UCLA with a B.S. in Cognitive Science and a minor in Society and Genetics. When not in lab, I can be found either chasing after a frisbee or watching other people chase after a football (or basketball, or baseball, or soccer ball). Life goals include winning a USA Ultimate national championship and setting more life goals.
April Kiyomi Hishinuma
April is majoring in cognitive science with an emphasis in neuroscience. Her love for the brain has lead her to pursue an occupation in both research and health care. She aspires to learn as much as she can about the brain before attending medical school. When not found studying, she will usually be spotted working out at the gym, singing with her guitar, or eating with friends.
George is a third year Public Health major, interested in mental and neurological health. He is more than certain that he will eventually be resurrected as a zombie–he just loves brains that much.
I am an undergrad here at UC Berkeley intending to major in MCB with a Neurobiology emphasis. I plan on pursuing a career in research and/or medicine, depending on how I fare for the next couple of years.
I’m a senior at UC Berkeley with a major in Molecular and Cell Biology with a Neurobiology emphasis. I am currently working on a senior thesis regarding the differences between the variants of Alzheimer’s Disease. When not in lab, I am often keeping up with the latest basketball and soccer news, listening to music and learning to play a song on the piano, or playing FIFA. In the future, I hope to attend medical school and continue research as a clinical neuropsychologist.
I am a currently a 2nd year here at UC Berkeley from New Jersey. Outside of the lab, you can find me at the library, gym, or the pool. I enjoy eating all kinds of foods, watching movies, and attending concerts. Other than that, I spend my days struggling to learn how to cook and speak a third language.
Hi! I’m a Junior double majoring in bioengineering and electrical engineering and computer science. I’m fascinated by the possibility in the future that humans will be able to control robotic limbs and prosthesis with their minds, and as a result I love learning how the brain works. I also love cooking jambalaya, impressing myself on the piano, and lifting heavy things in the gym and putting them back down.
- After yee-hawing my way from Missouri to the wild west coast, I’m here to stay. I’m a first year Cal undergrad planning to major in Cognitive Science with an emphasis in Neuroscience. When I’m not furiously doing homework, I’m trying new restaurants around town and watching Friday Night Lights.
- I am a third year student at UC Berkeley. I aspire to do clinical research in the future.
Stacey is a third year majoring in Molecular and Cell Biology with an emphasis in Neurobiology. She is particularly interested in clinical studies of the brain and hopes to attend medical school in the future. Stacey also enjoys spending her time sketching still-life and throwing around a frisbee.
Andreas is a recent graduate of UC Berkeley with a degree in Cognitive Science, having completed his honors thesis in the Jagust Lab. After working as an undergraduate in the Jagust Lab for 3 years, Andreas has joined Gil’s team at the UCSF Memory and Aging Center as a Clinical Research Coordinator, working primarily with PET imaging. Outside of the world of neurology, you can catch Andreas riding his bike from cafe to cafe throughout the East Bay and hitting a local live show whenever possible.
Jamie is a recent graduate from the newest UC campus, Merced, with a B.S. in Cognitive Science. She is now assisting in PET processing and is particularly interested in eventually continuing her education in brain sciences research. She loves animals, especially her family’s two Swedish Vallhunds, Fox and Goose, and ferocious cat, Darwin. When away from the lab she can be found watching sports, cooking yummy meals, and enjoying the outdoors.
I completed my PhD in neuroscience at the University of Minnesota in the lab of Eric Newman, where I studied blood flow regulation in the rat retinal vascular network. My research in the Jagust lab focuses on understanding how aging-related changes in memory and cognition are associated with brain amyloid deposition, as measured with PET.
henry dot schwimmer at gmail dot com
When not in the lab, he can be found shredding the gnar in Tahoe or hiking the backcountry with his harmonica. Henry is on his way to start med school at Emory! As a long-time staple in the Jagust Lab, he will leave a big hole in our hearts.
Jacob VogelGraduated from Hampshire College with a degree in Neuroscience. Interests include Neuroimaging, Statistics, Clinical Neuro, and Neuroendocrinology. Jake is off to pursue is PhD at McGill!
My research in the Jagust lab examines cognitive, structural, and functional alterations in relation to normal aging and pathological aging involving beta-amyloid deposition using multimodality imaging techniques of PIB-PET, FDG-PET, structural MRI, and fMRI and neuropsychological tests.
Prior to the Jagust lab, I received my PhD from SUNY-Stony Brook in 2009,where I worked with Hoi-Chung Leung. My doctoral research focused on the behavioral and neural bases of working memory, specifically, executive processes and an interaction of visual and verbal representations in healthy young adults.
[Oh2012_2] Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly Oh H, Habeck C, Madison C, Jagust W Human Brain Mapping, epub Sep 11, 2012 Human Brain Mapping Link
[Oh2012] Effects of age and β-amyloid on cognitive changes in normal elderly people (2012) Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust Neurobiology of Aging 2012 science direct
I received my PhD from UC Berkeley in 2012 under Arthur Shimamura. My doctoral research investigated contributions of the posterior parietal cortex to episodic memory using fMRI. As part of the Jagust lab, my research focuses on alterations in cognitive performance and multi-modal imaging biomarkers as a function of beta-amyloid deposition employing techniques that include structural MRI, task-based and resting-state fMRI, and PIB-PET.
Allie graduated from Berkeley with a degree in physics and joined the to help with PET scan image analysis. She left us for a brief stint in the industry world and will likely be pursuing a graduate degree in Environmental Engineering at MIT or UCSD (we don’t know yet) this fall! Go Allie!!
villeneuve dot sylvia at gmail dot com
Sylvia is currently completing a postdoc at Northwestern, and has recently been accepted for a tenure-track position at McGill!! We will miss her energy and enthusiasm, but we’re happy she’s finally going home!
Sylvia completed a Ph.D. in Neuropsychology at University of Montreal in 2011, with Dr. Sylvie Belleville. Her doctoral work focused on the impact of vascular diseases on the cognitive profile of persons with mild cognitive impairment.
Her main goal in the Jagust lab was to learn PIB-PET and FDG-PET imaging techniques. Her research examined the interaction between beta-amyloid deposition, glucose metabolism, vascular diseases and genetic factors, and their impact on neuropsychological measures and cognitive status.
Villeneuve et al., Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions. Neurology. 2014;83:40-47 http://www.ncbi.nlm.nih.gov/pubmed/24907234
Villeneuve et al. Cortical thickness mediates the effect of β-amyloid on episodic memory. Neurology. 2014;82:761-767 http://www.ncbi.nlm.nih.gov/pubmed/24489134
Pia was an instrumental member in helping to build Gil’s lab and was an organizing master–so much so that we needed TWO people to replacer her!! She is now gracing our nation’s capital pursuing an MA in Physiology at Georgetown.
Renaud La Joie
Renaud joined our lab after pursuing a PhD with Gaël Chételat which was the beginning of what we hope is a long term collaboration.
He has since betrayed us to go back to France to waste his time in med school in Lyon. His incredible wealth of information, collaborative spirit, and dashing good looks will be sorely missed in the Jagust Lab.
Sam is on his way to pursue a PhD in Clinical Pysch at Florida State University. Later gator!
Monika Varga Doležalová
Monika has returned to her hospital in Slovakia. She leaves behind some excellent research on subjective memory complaint, and a lab full of admirers.
Samia K. Arthur-Bentil
Samia pioneered the reconstruction of the lab’s PET scan data and came to the lab to explore the mystery of neurodegenerative disease via command line interfaces. She is now attending Brown University’s medical school, and is surely impressing everybody as always.
Helaine St. Amant
Helaine graduated with a degree in Molecular and Cell Biology with an emphasis in Neurobiology. She has now embarked on the long road to becoming a fantastic medical doctor.
Cindee has moved on the magical world of industry where she is currently working on a secret project that will inevitably blow your mind. Her invaluable programming expertise and deep kindness will always be rememberd as an indelible feature of the Jagust Lab!
She codes and loves Python
my blog rationalgirl.com
Scott Roberts, PhD came to the Jagust Lab from the University of Michigan School of Public Health, where he is Associate Professor of Health Behavior and Health Education. Dr. Roberts’ research addresses ethical and psychosocial issues involved in disclosing genetic risk information for adult-onset conditions, with Alzheimer’s disease as a primary focus. He is Co-PI of the longstanding REVEAL (Risk Evaluation and Education for Alzheimer’s Disease) Study, a NIH-funded series of randomized clinical trials examining the psychological and behavioral impact of APOE genotyping on first-degree relatives of people with AD. He also serves on ethics advisory boards for forthcoming large-scale AD prevention trials including the A4 Study and Alzheimer’s Prevention Initiative.
Andrea has been called back to a position in a top secret lab who existence is still denied. She is assisting in the lab part-time, but only if we don’t ask her about the secret lab.
Tad has moved on to a post-doc at the NIH on the other side of the states. Everyone will miss his insight on statistical analysis.
Relative contributions of biomarkers in Alzheimer’s Disease. Haight, TJ, Jagust, WJ. Annals of Epidemiology (2012)22:868-875
Dissociable effects of Alzheimer’s Disease and White Matter Hyperintensities on Brain Metabolism. Haight, T, Landau,S, Carmichael, O,Schwarz, C, DeCarli, C, Jagust, W. JAMA Neurology (2013) 70(8): 1039-1045
Manja was a visiting research scholar from London (UK) who joined the Memory and Aging Center at UCSF in October 2011. She continues her postdoctoral work at the Dementia Research Center at University College London: http://www.ucl.ac.uk/drc.
Her research aims to investigate functional connectivity networks in the brain, in particular in patients with different variants of Alzheimer’s disease, including Posterior Cortical Atrophy (visual variant), Logopenic Progressive Aphasia (language variant), and typical Alzheimer’s disease (amnestic variant).
[Lehmann2013] Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD Brain. 2013 Mar;136(Pt 3):844-58
Grace presented a wonderful paper for her Honors thesis.
Cognitive Phenotypes and AD Biomarkers in Healthy Adults CSSA Poster (pdf)
Grace is continuing to impress while studying Cell Biology in Graduate School at ETH in Switzerland. She is planning to focus her research on neuropathies.
Tricia graduated, and is now working as a Research Assistant at the Stanford Cognitive and Systems Neuroscience Laboratory to examine the development and improvement of math abilities in children.
Hyesoo rotated through our lab from MCB, and investigated the deposition pattern of Beta Amyloid in a cognitively normal old cohort.
Elizabeth rotated in the lab looking at the relationship between Beta Amyloid and three intrinsically connected networks (Default Mode, Dorsal Attention, Frontal Parietal Control Network ).
Linh Cat Dang
Linh has moved to a post-doc at Vanderbilt University where she will continue with her work on Dopamine
Rik has returned to VU University medical center in Amsterdam (Alzheimer center and department of Nuclear Medicine & PET Research) after a very productive 6 months of research and teaching the Americans how to play a proper game of soccer. He will be sorely missed.
Award Winning Talk
Increased Parietal Amyloid Burden and Metabolic Dysfunction in Alzheimer’s Disease with Early Onset SNM2012 (pdf)
Amyloid burden and metabolic function in early-onset Alzheimer’s disease: parietal lobe involvement (2012) Ossenkoppele R et al. Brain. 2012 Jul :2115-25 pubmed
Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET. Ossenkoppele R et al. Eur J Nucl Med Mol Imaging. 2012 Jun;39(6):990-1000. pubmed
Candace has left us for warmer temps, and there is still a secret list for people who want her to be their doctor once she finishes up at Emory Medical School....its a long list
Aneesh has come under the influence of the Jagust love of research and decided against Medical School. You can now find him pursuing a PhD at Johns Hopkins.
Has finished his PhD with great style, and returned to research closer to his wife and son. Still holds the lab record for most quickly accepted manuscript (less than 24 hours)
Graduated and working in a UCSF schizophrenia lab.
Chiara Martina Corbetta-Rastelli
Moved on to exploring user-interfaces
We are proud to report that Natalie is now Lecturer (Assistant Professor) in Old Age Psychiatry at The Institute of Psychiatry, King’s College London https://kclpure.kcl.ac.uk/portal/natalie.marchant.html
[Marchant2011] Cerebrovascular disease, beta-amyloid and cognition in aging.
Marchant, N.L., King, S.L., Tabet, N., & Rusted, J.M. (2010). Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers. Neuropsychopharmacology. 2010 Apr;35(5) pubmed
Presentations and Posters
Benedicte has her hands full with Carmen, and exciting new aspects of science to explore.
Courtney is a first year graduate student in the Helen Wills Neuroscience Institute. Her project while rotating in the Jagust Lab investigated FDG hypometabolism associated with fMRI task activation in a Healthy Elderly Cohort with Amyloid burden.
Has returned to Canada, but left us so much a wiser.
Adi is returning to the homeland to complete her medical residency, as soon as she finishes her third genetic research project. She will be missed.
Has left the Academic world to explore the exciting fast-paced world of start-ups, working with educational software.
Worked with Suzanne on PIB, but has left to loftier pursuits
Amynta has left us for Graduate School to pursue a career in Clinical Psychology, though she already proved her skills by handling the behavioral disorders of the researchers in our lab.
Returned to the University of Milan where he is a resident in Nuclear Medicine
Returned to Switzerland to finish her PhD.
Ellen Klostermann Wallace
Ellen recently left the cool warmth of Berkeley for the balmy snow of Chicago, she is deeply missed. Here is a recent presentation she had.
Matar rotated through our lab as a first year graduate student.
Ara Hrire Rostomian
Left us for UCLA Medical School
Heading to Medical School at USCD, another one lost despite the seductive pull of the dark side.
Heading to Medical School at UC Davis, despite our efforts to turn him to the dark side.
Has moved to Stanford/ VA Palo Alto
Mistress of Meta-Memory
Has left us for the Universoty of Caen in her native France
Now at UCLA
Now at Michael J. Fox Foundation
Now at UC Davis
Talented young scientist, uniquely able to explain the physics, unravel the plot twists and expound upon the complex and deeper meaning of LOST through a series of power point presentations.
We begged him to stay, but he left us for medical school at UC Davis.
Medical Student UCSF
Clinical Fellow/Neurologist from UCSF
Visiting Miller Professor She has returned to Israel Research Page
Medical Student UCSF