I received my PhD from UC Berkeley in 2012 under Arthur Shimamura. My doctoral research investigated contributions of the posterior parietal cortex to episodic memory using fMRI. As part of the Jagust lab, my research focuses on alterations in cognitive performance and multi-modal imaging biomarkers as a function of beta-amyloid deposition employing techniques that include structural MRI, task-based and resting-state fMRI, and PIB-PET.
Elman, J. A., Cohn-Sheehy, B. I., & Shimamura, A. P. (2013). Dissociable parietal regions facilitate successful retrieval of recently learned and personally familiar information. Neuropsychologia, 51(4), 573–583. doi:10.1016/j.neuropsychologia.2012.12.013 pubmed
Elman, J. A., Klostermann, E. C., Marian, D. E., Verstaen, A., & Shimamura, A. P. (2012). Neural correlates of metacognitive monitoring during episodic and semantic retrieval. Cognitive, Affective, & Behavioral Neuroscience, 1–11. doi:10.3758/s13415-012-0096-8 pubmed
Elman, J. A., & Shimamura, A. P. (2011). Task relevance modulates successful retrieval effects during explicit and implicit memory tests. NeuroImage, 56(1), 345–353. doi:10.1016/j.neuroimage.2011.02.017 pubmed
Renaud La Joie
After spending five years studying patients with Alzheimer’s disease using hippocampal subfield measurement, structural MRI, Florbetapir-PET and FDG-PET under the rainy and cloudy sky of Normandy with Gaël Chételat.
I arrived in Jagust lab in may 2013 to experience Californian weather. And also potentially to study the impact of beta-amyoid on brain function in healthy aged people.
My research in the Jagust lab examines cognitive, structural, and functional alterations in relation to normal aging and pathological aging involving beta-amyloid deposition using multimodality imaging techniques of PIB-PET, FDG-PET, structural MRI, and fMRI and neuropsychological tests.
Prior to the Jagust lab, I received my PhD from SUNY-Stony Brook in 2009,where I worked with Hoi-Chung Leung. My doctoral research focused on the behavioral and neural bases of working memory, specifically, executive processes and an interaction of visual and verbal representations in healthy young adults.
[Oh2012_2] Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly Oh H, Habeck C, Madison C, Jagust W Human Brain Mapping, epub Sep 11, 2012 Human Brain Mapping Link
[Oh2012] Effects of age and β-amyloid on cognitive changes in normal elderly people (2012) Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust Neurobiology of Aging 2012 science direct
Cognitive and Structural Changes in Cognitively Older Adults without Amyloid Deposition (2011) ACC Dallas poster (pdf)
Monika Varga Doležalová
Working as a psychologist in Neurology clinic in my homeland I felt it would be meaningful to zoom out and see what was really happening in a big and progressive world of neuroscience. This has happened to be real thanks to a Fulbright grant. Being a visiting student researcher, my main interest is cognitive neuroscience, but cannot wait to learn more about neuroimaging!
sylvia dot villeneuve at gmail dot com
I completed a Ph.D. in Neuropsychology at University of Montreal in 2011, with Dr. Sylvie Belleville. My doctoral work focused on the impact of vascular diseases on the cognitive profile of persons with mild cognitive impairment.
My main goal in the Jagust lab is to learn PIB-PET and FDG-PET imaging techniques. My research will examine the interaction between beta-amyloid deposition, glucose metabolism, vascular diseases and genetic factors, and their impact on neuropsychological measures and cognitive status.
The nature of memory failure in mild cognitive impairment: examining association with neurobiological markers and effect of progression. Villeneuve S, Belleville S. Neurobiol Aging. 2011 Nov 14. [Epub ahead of print] pubmed
I am a postdoctoral fellow at the Jagust Lab (PI: Prof. William Jagust), Helen Wills Neuroscience Center, University of California, Berkeley.
A central focus of my research work is to understand normal aging, detect pathological aging and identify life-style as well as genetic factors that contribute to differential aging of neural and cognitive functions.
I have trained in multimodal neuroimaging, including structural and functional task- and resting-state MRI, EEG, PET and non-invasive stimulation techniques, such as tDCS and TMS. At the Jagustlab, I am using biomarkers of PIB and FDG PET together with structural MRI to study the stage of preclinical Alzheimer’s disease in cognitively normal older individuals.
Regularly visits from UCSF, Stanford Alum, Cubs fan!
[Rabinovici2011] Amyloid versus FDG-PET in the differential diagnosis of AD and FTLD
[Rabinovici2010] Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden
[Rabinovici2008] AB amyloid and glucose metabolism in three variants of primary progressive aphasia
Scott Roberts, PhD comes to the Jagust Lab from the University of Michigan School of Public Health, where he is Associate Professor of Health Behavior and Health Education. Dr. Roberts’ research addresses ethical and psychosocial issues involved in disclosing genetic risk information for adult-onset conditions, with Alzheimer’s disease as a primary focus. He is Co-PI of the longstanding REVEAL (Risk Evaluation and Education for Alzheimer’s Disease) Study, a NIH-funded series of randomized clinical trials examining the psychological and behavioral impact of APOE genotyping on first-degree relatives of people with AD. He also serves on ethics advisory boards for forthcoming large-scale AD prevention trials including the A4 Study and Alzheimer’s Prevention Initiative.
Dr. Roberts is interested in using his sabbatical at the Jagust Lab to begin to develop and evaluate approaches for disclosing amyloid imaging results to individuals at-risk for clinical AD. He also hopes to use this time to explore the Bay Area with his wife (a Berkeley native) and two children.
Roberts, J. S. (2012). Genetic testing for Alzheimer’s risk: Benefit or burden? Neurodegenerative Disease Management, 2(2), 141-44. online
Roberts, J. S., Chen, C., Uhlmann, W., & Green R. C. (2012). Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer’s disease: The REVEAL Study. Genetics in Medicine, 14, 742-48. pubmed
Roberts, J.S., Christensen, K. D., & Green, R. C. (2011). Using Alzheimer’s disease as a model for genetic risk disclosure: Implications for personal genomics. Clinical Genetics, *80, 407-14.* pubmed
Katelyn has joined our lab and plans to continue working on relating FDG with network modularity in an older cognitively normal cohort.
Back for another round of research, stay tuned for exciting findings.
Samia K. Arthur-Bentil
Samia pioneers the reconstruction of the lab’s PET scan data and is here to explore the mystery of neurodegenerative disease via command line interfaces. When not bonding with her Sun, she enjoys dancing, searching for her new favorite restaurant and having intellectual conversations about bad television.
Suzanne swims with the sharks and will devour wimpy little men all while juggling MRI and PET scanners!
Brendan is a recent UC Berkeley graduate who is looking forward to an exciting career in neurology practice and research, and is interested in everything from neurodegeneration to the cognitive neuroscience of music. When not analyzing PET and MRI data, he writes, records, and performs music and poetry.
Sam is spends his time in the lab on neuropsychological testing and helping with PET scans. When not working he can be found scarfing down a bratwurst from Top Dog or flipping through the vinyl at Amoeba.
I just graduated from Berkeley with a degree in physics. I’m here to help with PET scan image analysis, and hopefully learn a little about neuroscience while I’m at it. When I’m not here or at home I’m probably out trying new restaurants in San Francisco or skiing up in Tahoe (or trying new restaurants in Tahoe).
Pia works with Gil to pair clinical findings with brain imaging analysis to improve early stage diagnosis. Traveling to new places and music keep her pulse dancing.
[Landau2012] Lifetime cognitive engagement is associated with low beta-amyloid deposition
[Landau2012_2] Amyloid deposition, hypometabolism, and longitudinal cognitive decline
[Landau2012_3] Amyloid-b Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods
[Landau2009_2] Associations between cognitive, functional, and FDG-PET measures of decline in AD and MC
Andrea has been called back to a position in a top secret lab who existence is still denied. She is assisting in the lab part-time, but only if we don’t ask her about the secret lab.
Kris is a radiologist specialist working to collect PET data.
When not in the lab, he can be found shredding the gnar in Tahoe or hiking the backcountry with his harmonica. Online chatters beware: he despises emoticons.
Arrived from the east coast and is confused by all of the smiling and contentment (must be the sunshine). Interests include Clinical Neuro and Neuroendo. When not managing the endeavors of the JagustLab, he’s probably watching a Phils game, recording music or failing at cooking.
Double majoring in MCB Neuroscience and Psychology; fascinated with the brain and hopes to receive a Ph. D. in neuropsychology to research why people behave the way they do. Outside of school and working, she loves to discover new bands and go concert hoping.
Sam Greene is 2nd year majoring in Neurobiology and planning on applying to Medical School in the fall of 2015. He is interested in pursuing a career in health care or research and loves to stay active with his free time. He is currently training for his first ever marathon on October 20th, 2013. You can find Sam working, studying, sleeping in lab or at his fraternity house playing FIFA.
Helaine St. Amant
Helaine is a senior undergraduate student majoring in Molecular and Cell Biology with an emphasis in Neurobiology. She is fascinated by the complexity of the brain and hopes to learn as much as she can before attending medical school. Aside from school and the lab, she likes to spend her free time by getting outside and relaxing with friends and family. Go Bears!
I’m a 3rd year majoring in MCB - Neuro. Aspiring to attend pharmacy school after graduating. I love studying about the brain and cognitive function. I hope to attain a MA/PhD in Neuroscience in the future.
Tad has moved on to a post-doc at the NIH on the other side of the states. Everyone will miss his insight on statistical analysis.
Manja was a visiting research scholar from London (UK) who joined the Memory and Aging Center at UCSF in October 2011. She continues her postdoctoral work at the Dementia Research Center at University College London: http://www.ucl.ac.uk/drc.
Her research aims to investigate functional connectivity networks in the brain, in particular in patients with different variants of Alzheimer’s disease, including Posterior Cortical Atrophy (visual variant), Logopenic Progressive Aphasia (language variant), and typical Alzheimer’s disease (amnestic variant).
[Lehmann2013] Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD Brain. 2013 Mar;136(Pt 3):844-58
Grace presented a wonderful paper for her Honors thesis.
Cognitive Phenotypes and AD Biomarkers in Healthy Adults CSSA Poster (pdf)
Grace is continuing to impress while studying Cell Biology in Graduate School at ETH in Switzerland. She is planning to focus her research on neuropathies.
Tricia graduated, and is now working as a Research Assistant at the Stanford Cognitive and Systems Neuroscience Laboratory to examine the development and improvement of math abilities in children.
Hyesoo rotated through our lab from MCB, and investigated the deposition pattern of Beta Amyloid in a cognitively normal old cohort.
Elizabeth rotated in the lab looking at the relationship between Beta Amyloid and three intrinsically connected networks (Default Mode, Dorsal Attention, Frontal Parietal Control Network ).
Linh Cat Dang
Linh has moved to a post-doc at Vanderbilt University where she will continue with her work on Dopamine
Rik has returned to VU University medical center in Amsterdam (Alzheimer center and department of Nuclear Medicine & PET Research) after a very productive 6 months of research and teaching the Americans how to play a proper game of soccer. He will be sorely missed.
Award Winning Talk
Increased Parietal Amyloid Burden and Metabolic Dysfunction in Alzheimer’s Disease with Early Onset SNM2012 (pdf)
Amyloid burden and metabolic function in early-onset Alzheimer’s disease: parietal lobe involvement (2012) Ossenkoppele R et al. Brain. 2012 Jul :2115-25 pubmed
Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET. Ossenkoppele R et al. Eur J Nucl Med Mol Imaging. 2012 Jun;39(6):990-1000. pubmed
Candace has left us for warmer temps, and there is still a secret list for people who want her to be their doctor once she finishes up at Emory Medical School....its a long list
Aneesh has come under the influence of the Jagust love of research and decided against Medical School. You can now find him pursuing a PhD at Johns Hopkins.
Has finished his PhD with great style, and returned to research closer to his wife and son. Still holds the lab record for most quickly accepted manuscript (less than 24 hours)
Graduated and working in a UCSF schizophrenia lab.
Chiara Martina Corbetta-Rastelli
Moved on to exploring user-interfaces
Natalie has left us for an amazing globe-stomping adventure.
[Marchant2011] Cerebrovascular disease, beta-amyloid and cognition in aging.
Marchant, N.L., King, S.L., Tabet, N., & Rusted, J.M. (2010). Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers. Neuropsychopharmacology. 2010 Apr;35(5) pubmed
Presentations and Posters
Benedicte has her hands full with Carmen, and exciting new aspects of science to explore.
Courtney is a first year graduate student in the Helen Wills Neuroscience Institute. Her project while rotating in the Jagust Lab investigated FDG hypometabolism associated with fMRI task activation in a Healthy Elderly Cohort with Amyloid burden.
Has returned to Canada, but left us so much a wiser.
Adi is returning to the homeland to complete her medical residency, as soon as she finishes her third genetic research project. She will be missed.
Has left the Academic world to explore the exciting fast-paced world of start-ups, working with educational software.
Worked with Suzanne on PIB, but has left to loftier pursuits
Amynta has left us for Graduate School to pursue a career in Clinical Psychology, though she already proved her skills by handling the behavioral disorders of the researchers in our lab.
Returned to the University of Milan where he is a resident in Nuclear Medicine
Returned to Switzerland to finish her PhD.
Ellen Klostermann Wallace
Ellen recently left the cool warmth of Berkeley for the balmy snow of Chicago, she is deeply missed. Here is a recent presentation she had.
Matar rotated through our lab as a first year graduate student.
Ara Hrire Rostomian
Left us for UCLA Medical School
Heading to Medical School at USCD, another one lost despite the seductive pull of the dark side.
Heading to Medical School at UC Davis, despite our efforts to turn him to the dark side.
Has moved to Stanford/ VA Palo Alto
Mistress of Meta-Memory
Has left us for the Universoty of Caen in her native France
Now at UCLA
Now at Michael J. Fox Foundation
Now at UC Davis
Talented young scientist, uniquely able to explain the physics, unravel the plot twists and expound upon the complex and deeper meaning of LOST through a series of power point presentations.
We begged him to stay, but he left us for medical school at UC Davis.
Medical Student UCSF
Clinical Fellow/Neurologist from UCSF
Visiting Miller Professor She has returned to Israel Research Page
Medical Student UCSF