My research focuses on understanding why cognitive flexibility, the ability to dynamically respond to new task demands, declines with age. I am examining factors such as decreases in brain volume, dysregulation of the neurotransmitter dopamine, and changes in brain network activity.
I completed my PhD at the University of Michigan where I worked with Drs. Cindy Lustig and Martin Sarter. Broadly, my doctoral research investigated the contribution of the neurotransmitter acetylcholine to the control of attention.
I received my PhD from UC Berkeley in 2012 under Arthur Shimamura. My doctoral research investigated contributions of the posterior parietal cortex to episodic memory using fMRI. As part of the Jagust lab, my research focuses on alterations in cognitive performance and multi-modal imaging biomarkers as a function of beta-amyloid deposition employing techniques that include structural MRI, task-based and resting-state fMRI, and PIB-PET.
Elman, J. A., Cohn-Sheehy, B. I., & Shimamura, A. P. (2013). Dissociable parietal regions facilitate successful retrieval of recently learned and personally familiar information. Neuropsychologia, 51(4), 573–583. doi:10.1016/j.neuropsychologia.2012.12.013 pubmed
Elman, J. A., Klostermann, E. C., Marian, D. E., Verstaen, A., & Shimamura, A. P. (2012). Neural correlates of metacognitive monitoring during episodic and semantic retrieval. Cognitive, Affective, & Behavioral Neuroscience, 1–11. doi:10.3758/s13415-012-0096-8 pubmed
Elman, J. A., & Shimamura, A. P. (2011). Task relevance modulates successful retrieval effects during explicit and implicit memory tests. NeuroImage, 56(1), 345–353. doi:10.1016/j.neuroimage.2011.02.017 pubmed
My research project in the Jagust lab examines neuroimaging biomarkers of preclinical Alzheimer’s Disease (AD). Preclinical progression along the AD pathological cascade may be inadvertently conflated with the normal aging process in many studies seeking to understand the causes of gradual cognitive decline late in life. Therefore, our goal is to investigate effects of tau and Aβ accumulation (measured using PET) on structural connectivity between these regions (measured using MRI and DTI), and the relative effects of these brain differences on memory performance.
I earned my PhD from UC Davis in 2014, working with Dr. Charles DeCarli to investigate the contributions of age and CVD-related white matter injury (white matter hyperintensities or WMH) to attentional control network function and cognitive performance.
LOCKHART, S. N., Roach, A. E., Luck, S. J., Geng, J., Beckett, L., Carmichael, O., & DeCarli, C. (2014). White matter hyperintensities are associated with visual search behavior independent of generalized slowing in aging. Neuropsychologia, 52, 93–101. PMC3924853. pubmed
Maillard, P., Fletcher, E., LOCKHART, S. N., Roach, A. E., Reed, B., Mungas, D., DeCarli, C., & Carmichael, O. (2014). White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain. Stroke, 45(6), 1721-1726. PMID: 24781079. pubmed
Carmichael, O., & LOCKHART, S. N. (2012). The role of diffusion tensor imaging in the study of cognitive aging. C. S. Carter & J. W. Dalley (Eds.) Brain Imaging in Behavioral Neuroscience, (Vol.11) Current Topics in Behavioral Neurosciences. Springer Publishing: 289-320.
LOCKHART, S. N., Mayda, A. V., Roach, A. E., Fletcher, E., Carmichael, O., Maillard, P., Schwarz, C. G., Yonelinas, A. P., Ranganath, C., & DeCarli, C. (2012). Episodic Memory Function is Associated with Multiple Measures of White Matter Integrity in Cognitive Aging. Frontiers in Human Neuroscience, 6(56). PMC3305887. pubmed
hwameeoh at berkeley dot edu
My research in the Jagust lab examines cognitive, structural, and functional alterations in relation to normal aging and pathological aging involving beta-amyloid deposition using multimodality imaging techniques of PIB-PET, FDG-PET, structural MRI, and fMRI and neuropsychological tests.
Prior to the Jagust lab, I received my PhD from SUNY-Stony Brook in 2009,where I worked with Hoi-Chung Leung. My doctoral research focused on the behavioral and neural bases of working memory, specifically, executive processes and an interaction of visual and verbal representations in healthy young adults.
[Oh2012_2] Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly Oh H, Habeck C, Madison C, Jagust W Human Brain Mapping, epub Sep 11, 2012 Human Brain Mapping Link
[Oh2012] Effects of age and β-amyloid on cognitive changes in normal elderly people (2012) Hwamee Oh, Cindee Madison, Thaddeus J. Haight, Candace Markley, William J. Jagust Neurobiology of Aging 2012 science direct
At the Otto-von-Guericke University, Magdeburg, Germany (head: Prof. Hans-Jochen Heinze) I am working as neurologist, received my PhD in 2007 and finished my habilitation in 2014. During my habilitation I investigated the natural course of cerebral small vessel disease and its interplay with beta-amyloid-pathology in a hypertensive rat model. I came to the Jagust lab to learn biomarker PET and multimodal imaging techniques. My research in the lab will potentially focus on the interplay between biomarkers of neurodegeneration and of cerebral small vessel disease in the non-demented elderly.
Schreiber et al. Sonography of the median nerve in CMT1A, CMT2A, CMTX and HNPP. Muscle Nerve. 2013 Mar;47(3):385-95. http://www.ncbi.nlm.nih.gov/pubmed/23381770
Schreiber et al. The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? J Cereb Blood Flow Metab. 2012 Feb;32(2):278-90. http://www.ncbi.nlm.nih.gov/pubmed/21878945
villeneuve dot sylvia at gmail dot com
I completed a Ph.D. in Neuropsychology at University of Montreal in 2011, with Dr. Sylvie Belleville. My doctoral work focused on the impact of vascular diseases on the cognitive profile of persons with mild cognitive impairment.
My main goal in the Jagust lab is to learn PIB-PET and FDG-PET imaging techniques. My research will examine the interaction between beta-amyloid deposition, glucose metabolism, vascular diseases and genetic factors, and their impact on neuropsychological measures and cognitive status.
Villeneuve et al., Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions. Neurology. 2014;83:40-47 http://www.ncbi.nlm.nih.gov/pubmed/24907234
Villeneuve et al. Cortical thickness mediates the effect of β-amyloid on episodic memory. Neurology. 2014;82:761-767 http://www.ncbi.nlm.nih.gov/pubmed/24489134
Regularly visits from UCSF, Stanford Alum, Cubs fan!
[Rabinovici2011] Amyloid versus FDG-PET in the differential diagnosis of AD and FTLD
[Rabinovici2010] Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden
[Rabinovici2008] AB amyloid and glucose metabolism in three variants of primary progressive aphasia
Katelyn Arnemann (Begany)
I’m a PhD candidate in the Neuroscience Program at UC Berkeley. Employing multimodal brain imaging of age-/disease-related perturbations, my research aims to uncover (ideally fundamental) links between brain networks, cognition, and pathology.
shawn dot marks2 at gmail dot com
Back for another round of research, stay tuned for exciting findings.
Suzanne swims with the sharks and will devour wimpy little men all while juggling MRI and PET scanners!
I just graduated from Berkeley with a degree in physics. I’m here to help with PET scan image analysis, and hopefully learn a little about neuroscience while I’m at it. When I’m not here or at home I’m probably out trying new restaurants in San Francisco or skiing up in Tahoe (or trying new restaurants in Tahoe).
Assistant Research Scientist
slandau at berkeley dot edu
[Landau2014] Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers
[Landau2013] Comparing Positron Emission Tomography Imaging and Cerebrospinal Fluid Measurements of b-Amyloid
[Landau2012] Lifetime cognitive engagement is associated with low beta-amyloid deposition
[Landau2012_2] Amyloid deposition, hypometabolism, and longitudinal cognitive decline
[Landau2012_3] Amyloid-b Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods
[Landau2010] Comparing predictors of conversion and decline in mild cognitive impairment
[Landau2009_2] Associations between cognitive, functional, and FDG-PET measures of decline in AD and MC
Andreas is a recent graduate of UC Berkeley with a degree in Cognitive Science, having completed his honors thesis in the Jagust Lab. After working as an undergraduate in the Jagust Lab for 3 years, Andreas has joined Gil’s team at the UCSF Memory and Aging Center as a Clinical Research Coordinator, working primarily with PET imaging. Outside of the world of neurology, you can catch Andreas riding his bike from cafe to cafe throughout the East Bay and hitting a local live show whenever possible.
Kris is a radiologist specialist working to collect PET data.
I studied psychology at UCLA and am here to learn fMRI data analysis and anything else I can pick up along the way. Other things I am working on right now include winning my fantasy soccer league without putting Luis Suarez on my team, trying every kind of coffee from Philz, and guessing what the next season of American Horror Story will be about.
henry dot schwimmer at gmail dot comWhen not in the lab, he can be found shredding the gnar in Tahoe or hiking the backcountry with his harmonica. Online chatters beware: he despises emoticons.
As an undergrad here at Cal, I loved the interdisciplinary nature of Cognitive Science. I am fascinated by the intricacies and complexities of a ~3 pound piece of flesh we call the brain. I aim to better understand how it works, and apply these understandings to come up with meaningful innovations in the field of public health. Outside of the lab, you’re likely to find me playing Scrabble or Chess, enjoying chai tea, chocolate or cheese, traveling, or just exploring new places in the city with friends.
Graduated from Hampshire College with a degree in Neuroscience. Interests include Neuroimaging, Statistics, Clinical Neuro, and Neuroendocrinology. Currently managing Dr. Jagust’s lab and investigating subtle links between cognition and brain pathology in normally aging individuals. When not nerding out, you can find him recording music or watching a Phillies game.
Double majoring in MCB Neuroscience and Psychology; fascinated with the brain and hopes to receive a Ph. D. in neuropsychology to research why people behave the way they do. Outside of school and working, she loves to discover new bands and go concert hoping.
I am a third year student at UC Berkeley. I aspire to do clinical research in the future.
April Kiyomi Hishinuma
April is majoring in cognitive science with an emphasis in neuroscience. Her love for the brain has lead her to pursue an occupation in both research and health care. She aspires to learn as much as she can about the brain before attending medical school. When not found studying, she will usually be spotted working out at the gym, singing with her guitar, or eating with friends.
I am a Junior at UC Berkeley, studying Molecular Cell Biology with a focus in Neurobiology. I’m also hoping to finish a Computer Science minor. Starting the Fall 2014 semester, I will be facilitating the Kanye West DeCal (sign up!). When I’m not working, I take my time cooking nice meals, go on long bike rides, and swim as much as I can.
Hi! I’m a Junior double majoring in bioengineering and electrical engineering and computer science. I’m fascinated by the possibility in the future that humans will be able to control robotic limbs and prosthesis with their minds, and as a result I love learning how the brain works. I also love cooking jambalaya, impressing myself on the piano, and lifting heavy things in the gym and putting them back down.
I’m a senior at UC Berkeley with a major in Molecular and Cell Biology with a Neurobiology emphasis. I am currently working on a senior thesis regarding the differences between the variants of Alzheimer’s Disease. When not in lab, I am often keeping up with the latest basketball and soccer news, listening to music and learning to play a song on the piano, or playing FIFA. In the future, I hope to attend medical school and continue research as a clinical neuropsychologist.
I’m a 3rd year majoring in MCB - Neuro. Aspiring to attend pharmacy school after graduating. I love studying about the brain and cognitive function. I hope to attain a MA/PhD in Neuroscience in the future.
I am an undergraduate student at UC Berkeley expecting to graduate May 2017 with a major in Bioengineering.
Pia was an instrumental member in helping to build Gil’s lab and was an organizing master–so much so that we needed TWO people to replacer her!! She is now gracing our nation’s capital pursuing an MA in Physiology at Georgetown.
Renaud La Joie
Renaud joined our lab after pursuing a PhD with Gaël Chételat which was the beginning of what we hope is a long term collaboration.
He has since betrayed us to go back to France to waste his time in med school in Lyon. His incredible wealth of information, collaborative spirit, and dashing good looks will be sorely missed in the Jagust Lab.
Sam CrowleySam is on his way to pursue a PhD in Clinical Pysch at Florida State University. Later gator!
Monika Varga Doležalová
Monika has returned to her hospital in Slovakia. She leaves behind some excellent research on subjective memory complaint, and a lab full of admirers.
Samia K. Arthur-Bentil
Samia pioneered the reconstruction of the lab’s PET scan data and came to the lab to explore the mystery of neurodegenerative disease via command line interfaces. She is now attending Brown University’s medical school, and is surely impressing everybody as always.
Helaine St. Amant
Helaine graduated with a degree in Molecular and Cell Biology with an emphasis in Neurobiology. She has now embarked on the long road to becoming a fantastic medical doctor.
Cindee has moved on the magical world of industry where she is currently working on a secret project that will inevitably blow your mind. Her invaluable programming expertise and deep kindness will always be rememberd as an indelible feature of the Jagust Lab!
She codes and loves Python
Python in Berkeley python.berkeley.edu
Or join me at the py4science meeting
my blog rationalgirl.com
Miranka was a postdoctoral fellow at the Jagust Lab. She is now in Germany and is soon to make a research lab very, very lucky to have her!
The central focus of her work was to understand normal aging, detect pathological aging and identify life-style as well as genetic factors that contribute to differential aging of neural and cognitive functions.
She has trained in multimodal neuroimaging, including structural and functional task- and resting-state MRI, EEG, PET and non-invasive stimulation techniques, such as tDCS and TMS. At the Jagustlab, she used biomarkers of PIB and FDG PET together with structural MRI to study the stage of preclinical Alzheimer’s disease in cognitively normal older individuals.
Scott Roberts, PhD came to the Jagust Lab from the University of Michigan School of Public Health, where he is Associate Professor of Health Behavior and Health Education. Dr. Roberts’ research addresses ethical and psychosocial issues involved in disclosing genetic risk information for adult-onset conditions, with Alzheimer’s disease as a primary focus. He is Co-PI of the longstanding REVEAL (Risk Evaluation and Education for Alzheimer’s Disease) Study, a NIH-funded series of randomized clinical trials examining the psychological and behavioral impact of APOE genotyping on first-degree relatives of people with AD. He also serves on ethics advisory boards for forthcoming large-scale AD prevention trials including the A4 Study and Alzheimer’s Prevention Initiative.
Andrea has been called back to a position in a top secret lab who existence is still denied. She is assisting in the lab part-time, but only if we don’t ask her about the secret lab.
Tad has moved on to a post-doc at the NIH on the other side of the states. Everyone will miss his insight on statistical analysis.
Relative contributions of biomarkers in Alzheimer’s Disease. Haight, TJ, Jagust, WJ. Annals of Epidemiology (2012)22:868-875
Dissociable effects of Alzheimer’s Disease and White Matter Hyperintensities on Brain Metabolism. Haight, T, Landau,S, Carmichael, O,Schwarz, C, DeCarli, C, Jagust, W. JAMA Neurology (2013) 70(8): 1039-1045
Manja was a visiting research scholar from London (UK) who joined the Memory and Aging Center at UCSF in October 2011. She continues her postdoctoral work at the Dementia Research Center at University College London: http://www.ucl.ac.uk/drc.
Her research aims to investigate functional connectivity networks in the brain, in particular in patients with different variants of Alzheimer’s disease, including Posterior Cortical Atrophy (visual variant), Logopenic Progressive Aphasia (language variant), and typical Alzheimer’s disease (amnestic variant).
[Lehmann2013] Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD Brain. 2013 Mar;136(Pt 3):844-58
Grace presented a wonderful paper for her Honors thesis.
Cognitive Phenotypes and AD Biomarkers in Healthy Adults CSSA Poster (pdf)
Grace is continuing to impress while studying Cell Biology in Graduate School at ETH in Switzerland. She is planning to focus her research on neuropathies.
Tricia graduated, and is now working as a Research Assistant at the Stanford Cognitive and Systems Neuroscience Laboratory to examine the development and improvement of math abilities in children.
Hyesoo rotated through our lab from MCB, and investigated the deposition pattern of Beta Amyloid in a cognitively normal old cohort.
Elizabeth rotated in the lab looking at the relationship between Beta Amyloid and three intrinsically connected networks (Default Mode, Dorsal Attention, Frontal Parietal Control Network ).
Linh Cat Dang
Linh has moved to a post-doc at Vanderbilt University where she will continue with her work on Dopamine
Rik has returned to VU University medical center in Amsterdam (Alzheimer center and department of Nuclear Medicine & PET Research) after a very productive 6 months of research and teaching the Americans how to play a proper game of soccer. He will be sorely missed.
Award Winning Talk
Increased Parietal Amyloid Burden and Metabolic Dysfunction in Alzheimer’s Disease with Early Onset SNM2012 (pdf)
Amyloid burden and metabolic function in early-onset Alzheimer’s disease: parietal lobe involvement (2012) Ossenkoppele R et al. Brain. 2012 Jul :2115-25 pubmed
Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET. Ossenkoppele R et al. Eur J Nucl Med Mol Imaging. 2012 Jun;39(6):990-1000. pubmed
Candace has left us for warmer temps, and there is still a secret list for people who want her to be their doctor once she finishes up at Emory Medical School....its a long list
Aneesh has come under the influence of the Jagust love of research and decided against Medical School. You can now find him pursuing a PhD at Johns Hopkins.
Has finished his PhD with great style, and returned to research closer to his wife and son. Still holds the lab record for most quickly accepted manuscript (less than 24 hours)
Graduated and working in a UCSF schizophrenia lab.
Chiara Martina Corbetta-Rastelli
Moved on to exploring user-interfaces
We are proud to report that Natalie is now Lecturer (Assistant Professor) in Old Age Psychiatry at The Institute of Psychiatry, King’s College London https://kclpure.kcl.ac.uk/portal/natalie.marchant.html
[Marchant2011] Cerebrovascular disease, beta-amyloid and cognition in aging.
Marchant, N.L., King, S.L., Tabet, N., & Rusted, J.M. (2010). Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers. Neuropsychopharmacology. 2010 Apr;35(5) pubmed
Presentations and Posters
Benedicte has her hands full with Carmen, and exciting new aspects of science to explore.
Courtney is a first year graduate student in the Helen Wills Neuroscience Institute. Her project while rotating in the Jagust Lab investigated FDG hypometabolism associated with fMRI task activation in a Healthy Elderly Cohort with Amyloid burden.
Has returned to Canada, but left us so much a wiser.
Adi is returning to the homeland to complete her medical residency, as soon as she finishes her third genetic research project. She will be missed.
Has left the Academic world to explore the exciting fast-paced world of start-ups, working with educational software.
Worked with Suzanne on PIB, but has left to loftier pursuits
Amynta has left us for Graduate School to pursue a career in Clinical Psychology, though she already proved her skills by handling the behavioral disorders of the researchers in our lab.
Returned to the University of Milan where he is a resident in Nuclear Medicine
Returned to Switzerland to finish her PhD.
Ellen Klostermann Wallace
Ellen recently left the cool warmth of Berkeley for the balmy snow of Chicago, she is deeply missed. Here is a recent presentation she had.
Matar rotated through our lab as a first year graduate student.
Ara Hrire Rostomian
Left us for UCLA Medical School
Heading to Medical School at USCD, another one lost despite the seductive pull of the dark side.
Heading to Medical School at UC Davis, despite our efforts to turn him to the dark side.
Has moved to Stanford/ VA Palo Alto
Mistress of Meta-Memory
Has left us for the Universoty of Caen in her native France
Now at UCLA
Now at Michael J. Fox Foundation
Now at UC Davis
Talented young scientist, uniquely able to explain the physics, unravel the plot twists and expound upon the complex and deeper meaning of LOST through a series of power point presentations.
We begged him to stay, but he left us for medical school at UC Davis.
Medical Student UCSF
Clinical Fellow/Neurologist from UCSF
Visiting Miller Professor She has returned to Israel Research Page
Medical Student UCSF